HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.899

Property	Details
Experiments	30523153, 26186194, 28514442, 33961781
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 147
+	Hs
		475249 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20
+	Dm
		639414 Q9W418_DROME (1-228): 2.1e-92: 282: 100.00		UBCD1_DROME (1-147): 2.75e-82: 239: 94.56
+	Hs
		1137415 Q5U5U6_HUMAN (1-229): 4.07e-98: 286: 100.00		UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43
+	Hs
		475124 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43
+	Sc
		477103 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		UBC4_YEAST (3-147): 1.04e-79: 233: 80.00
+	Hs
		474958 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UBE2A_HUMAN (2-144): 1.41e-70: 210: 39.16
+	Rn
		88580 UBC_RAT (1-181): 2.6e-61: 206: 96.13		UB2D1_RAT (1-147): 7.06e-83: 241: 89.12
+	Mm
		476737 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UB2D3_MOUSE (1-147): 1.54e-81: 238: 97.28
+	Hs
		476604 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20
+	Hs
		475501 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		475586 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00
+	Hs
		475550 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Rn
		1144263 UBC_RAT (1-181): 2.6e-61: 206: 96.13		UBE2N_RAT (4-147): 2.87e-71: 212: 46.53
+	Mm
		476739 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBE2N_MOUSE (4-147): 7.67e-69: 206: 47.22
+	Hs
		476218 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73
+	Hs
		476155 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43
+	Hs
		475504 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73
+	Hs
		475485 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBE2A_HUMAN (2-144): 1.41e-70: 210: 39.16
+	Hs
		475597 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBE2B_HUMAN (2-144): 5.71e-70: 209: 37.76
+	Hs
		475552 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22