Protein: NFM
Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)

Gene: NFM, NEFM
Organism: Homo sapiens
Interactions: 200
UniProt ID: P07197

Gene Ontology (top 5):
GO:0005200 - structural constituent of cytoskeleton
GO:0005882 - intermediate filament
GO:0005883 - neurofilament
GO:0008017 - microtubule binding
GO:0030424 - axon

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

451311

VIME
Vimentin

11

20

High-throughput

0.977

High

451099

NFL
Neurofilament light polypeptide

9

20

High-throughput

0.969

High

451350

NEST
Nestin

4

20

High-throughput

0.892

High

451393

AINX
Alpha-internexin

3

20

High-throughput

0.861

High

451320

NFH
Neurofilament heavy polypeptide

3

20

High-throughput

0.855

High

451322

GFAP
Glial fibrillary acidic protein

2

20

High-throughput

0.811

High

451329

DESM
Desmin

2

20

High-throughput

0.811

High

451449

SYNCI
Syncoilin

2

20

High-throughput

0.811

High

436766

K1C18
Keratin, type I cytoskeletal 18

2

20

High-throughput

0.754

High

437057

K2C8
Keratin, type II cytoskeletal 8

2

20

High-throughput

0.754

High

300621

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.691

High

300719

KRT38
Keratin, type I cuticular Ha8

1

20

High-throughput

0.691

High

385037

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.691

High

451313

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.691

High

451314

K1C16
Keratin, type I cytoskeletal 16

1

20

High-throughput

0.691

High

451380

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.691

High

451387

K1H1
Keratin, type I cuticular Ha1

1

20

High-throughput

0.691

High

451399

K1C39
Keratin, type I cytoskeletal 39

1

20

High-throughput

0.691

High

451404

K1C27
Keratin, type I cytoskeletal 27

1

20

High-throughput

0.691

High

451411

KT222
Keratin-like protein KRT222

1

20

High-throughput

0.691

High

451394

KIF7
Kinesin-like protein KIF7

4

6

High-throughput

0.691

High

451386

PLEC
Plectin

3

20

High-throughput

0.667

High

451373

GOGA2
Golgin subfamily A member 2

2

20

High-throughput

0.628

High

227199

KRT86
Keratin, type II cuticular Hb6

1

20

High-throughput

0.618

High

451308

NFM
Neurofilament medium polypeptide

1

20

High-throughput

0.618

High

451312

K1C19
Keratin, type I cytoskeletal 19

1

20

High-throughput

0.618

High

451409

LUR1L
Leucine rich adaptor protein 1-like

3

2

High-throughput

0.609

High

451447

GAN
Gigaxonin

3

17

High-throughput

0.609

High

248969

EVI5
Ecotropic viral integration site 5 protein homolog

3

3

High-throughput

0.593

High

451454

DISC1
Disrupted in schizophrenia 1 protein

2

2

High-throughput

0.576

High

451309

CAN1
Calpain-1 catalytic subunit

2

7

High-throughput

0.574

High

451356

AF17
Protein AF-17

2

4

High-throughput

0.574

High

451371

CALD1
Caldesmon

2

20

High-throughput

0.574

High

451430

RSPRY
RING finger and SPRY domain-containing protein 1

2

12

High-throughput

0.574

High

451432

CC120
Coiled-coil domain-containing protein 120

2

5

High-throughput

0.574

High

451434

F167A
Protein FAM167A

2

1

High-throughput

0.574

High

451374

MYO9B
Unconventional myosin-IXb

2

18

High-throughput

0.558

High

451468

CRBG1
Beta/gamma crystallin domain-containing protein 1

2

20

High-throughput

0.558

High

61401

VWA8
von Willebrand factor A domain-containing protein 8

2

3

High-throughput

0.549

High

451417

CCHCR
Coiled-coil alpha-helical rod protein 1

2

20

High-throughput

0.549

High

249083

DSCAM
Cell adhesion molecule DSCAM

1

7

High-throughput

0.541

High

451461

TNIK
TRAF2 and NCK-interacting protein kinase

2

20

High-throughput

0.539

High

451345

HD
Huntingtin

1

11

High-throughput

0.536

High

451357

EPIPL
Epiplakin

1

20

High-throughput

0.536

High

451362

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.536

High

451367

ANK2
Ankyrin-2

1

15

High-throughput

0.536

High

451378

MAP7
Ensconsin

1

20

High-throughput

0.536

High

451323

DRD2
D(2) dopamine receptor

1

2

Small-scale

0.527

High

429154

JUN
Transcription factor Jun

2

16

High-throughput

0.521

High

370517

FOS
Protein c-Fos

1

13

High-throughput

0.512

High

451391

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.512

High

451392

ITSN1
Intersectin-1

1

20

High-throughput

0.494

High

258724

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.489

High

451310

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

10

High-throughput

0.489

High

451324

IDE
Insulin-degrading enzyme

1

12

High-throughput

0.489

High

451334

S100P
Protein S100-P

1

18

High-throughput

0.489

High

451342

NUP62
Nuclear pore glycoprotein p62

1

5

High-throughput

0.489

High

451349

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.489

High

451364

HBB
Hemoglobin subunit beta

1

4

High-throughput

0.489

High

451368

LAT1
Large neutral amino acids transporter small subunit 1

1

2

High-throughput

0.489

High

451370

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

2

High-throughput

0.489

High

451375

SQSTM
Sequestosome-1

1

7

High-throughput

0.489

High

451379

SRC8
Src substrate cortactin

1

20

High-throughput

0.489

High

451383

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

13

High-throughput

0.489

High

451388

SSXT
Protein SSXT

1

2

High-throughput

0.489

High

451390

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.489

High

451395

CF184
Cilia- and flagella-associated protein 184

1

2

High-throughput

0.489

High

451398

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

20

High-throughput

0.489

High

451410

SYCE1
Synaptonemal complex central element protein 1

1

2

High-throughput

0.489

High

451424

YLAT2
Y+L amino acid transporter 2

1

2

High-throughput

0.489

High

451451

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

1

High-throughput

0.489

High

451460

STML2
Stomatin-like protein 2, mitochondrial

1

2

High-throughput

0.489

High

451469

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.489

High

330576

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

370941

MYC
Myc proto-oncogene protein

1

19

High-throughput

0.479

High

451327

DESP
Desmoplakin

1

20

High-throughput

0.479

High

451343

SYUA
Alpha-synuclein

1

5

High-throughput

0.479

High

451347

MAP1B
Microtubule-associated protein 1B

1

20

High-throughput

0.479

High

451354

PLK1
Serine/threonine-protein kinase PLK1

1

5

High-throughput

0.479

High

451384

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

451450

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

High-throughput

0.479

High

72911

FHAD1
Forkhead-associated domain-containing protein 1

1

16

High-throughput

0.470

High

451318

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.470

High

451402

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.458

High

387357

APOE
Apolipoprotein E

1

4

Small-scale

0.457

High

254742

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.445

High

451317

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.445

High

105135

APRIO
Alternative prion protein

1

10

High-throughput

0.437

High

156851

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.437

High

171159

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

14

High-throughput

0.437

High

175573

SR140
U2 snRNP-associated SURP motif-containing protein

1

1

High-throughput

0.437

High

220848

XPOT
Exportin-T

1

6

High-throughput

0.437

High

240506

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.437

High

246400

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.437

High

258053

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.437

High

329887

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

2

High-throughput

0.437

High

405685

MYCN
N-myc proto-oncogene protein

1

19

High-throughput

0.437

High

430958

LA
Lupus La protein

1

13

High-throughput

0.437

High

451319

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.437

High

451321

ADT1
ADP/ATP translocase 1

1

2

High-throughput

0.437

High

451325

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.437

High

451326

ETS1
Protein C-ets-1

1

2

High-throughput

0.437

High

451328

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

19

High-throughput

0.437

High

451330

RL7
Large ribosomal subunit protein uL30

1

1

High-throughput

0.437

High

451331

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

9

High-throughput

0.437

High

451332

GCSP
Glycine dehydrogenase

1

3

High-throughput

0.437

High

451335

PYR1
Multifunctional protein CAD

1

1

High-throughput

0.437

High

451339

MCM7
DNA replication licensing factor MCM7

1

12

High-throughput

0.437

High

451340

MYH9
Myosin-9

1

17

High-throughput

0.437

High

451341

MYH10
Myosin-10

1

17

High-throughput

0.437

High

451344

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

2

High-throughput

0.437

High

451346

NR4A2
Nuclear receptor subfamily 4 group A member 2

1

20

High-throughput

0.437

High

451348

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.437

High

451351

MCM2
DNA replication licensing factor MCM2

1

12

High-throughput

0.437

High

451352

R144A
E3 ubiquitin-protein ligase RNF144A

1

5

Small-scale

0.437

High

451353

MECP2
Methyl-CpG-binding protein 2

1

12

High-throughput

0.437

High

451358

RAC3
Ras-related C3 botulinum toxin substrate 3

1

4

High-throughput

0.437

High

451359

PRS8
26S proteasome regulatory subunit 8

1

4

High-throughput

0.437

High

451363

H2B1C
Histone H2B type 1-C/E/F/G/I

1

13

High-throughput

0.437

High

451365

PSG9
Pregnancy-specific beta-1-glycoprotein 9

1

5

High-throughput

0.437

High

451369

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

4

High-throughput

0.437

High

451372

DHX9
ATP-dependent RNA helicase A

1

1

High-throughput

0.437

High

451376

HDAC1
Histone deacetylase 1

1

19

High-throughput

0.437

High

451377

CUL4B
Cullin-4B

1

20

High-throughput

0.437

High

451381

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

3

Small-scale

0.437

High

451382

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

451385

EEA1
Early endosome antigen 1

1

20

High-throughput

0.437

High

451389

PCH2
Pachytene checkpoint protein 2 homolog

1

16

High-throughput

0.437

High

451396

MIDN
Midnolin

1

5

High-throughput

0.437

High

451400

BICL1
BICD family-like cargo adapter 1

1

20

High-throughput

0.437

High

451401

FA83H
Protein FAM83H

1

10

High-throughput

0.437

High

451403

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

5

High-throughput

0.437

High

451405

DRC11
Dynein regulatory complex protein 11

1

16

High-throughput

0.437

High

451407

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

20

High-throughput

0.437

High

451408

LRC49
Leucine-rich repeat-containing protein 49

1

11

High-throughput

0.437

High

451415

SYNE1
Nesprin-1

1

20

High-throughput

0.437

High

451416

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.437

High

451418

DLG5
Disks large homolog 5

1

10

High-throughput

0.437

High

451419

ATX2L
Ataxin-2-like protein

1

4

High-throughput

0.437

High

451420

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.437

High

451421

BBX
HMG box transcription factor BBX

1

6

High-throughput

0.437

High

451422

SSH1
Protein phosphatase Slingshot homolog 1

1

5

High-throughput

0.437

High

451423

TITIN
Titin

1

20

High-throughput

0.437

High

451425

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

15

High-throughput

0.437

High

451426

NU205
Nuclear pore complex protein Nup205

1

1

High-throughput

0.437

High

451428

CLUA1
Clusterin-associated protein 1

1

1

High-throughput

0.437

High

451429

PF21A
PHD finger protein 21A

1

20

High-throughput

0.437

High

451431

SPDLY
Protein Spindly

1

20

High-throughput

0.437

High

451436

NEB2
Neurabin-2

1

20

High-throughput

0.437

High

451437

ANM1
Protein arginine N-methyltransferase 1

1

11

High-throughput

0.437

High

451438

MICU1
Calcium uptake protein 1, mitochondrial

1

4

High-throughput

0.437

High

451440

DDX23
Probable ATP-dependent RNA helicase DDX23

1

3

High-throughput

0.437

High

451442

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.437

High

451443

FACD2
Fanconi anemia group D2 protein

1

20

High-throughput

0.437

High

451444

REN3B
Regulator of nonsense transcripts 3B

1

4

High-throughput

0.437

High

451445

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.437

High

451448

SENP3
Sentrin-specific protease 3

1

3

High-throughput

0.437

High

451452

ANM8
Protein arginine N-methyltransferase 8

1

11

High-throughput

0.437

High

451453

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.437

High

451455

DYH9
Dynein axonemal heavy chain 9

1

4

High-throughput

0.437

High

451456

STK26
Serine/threonine-protein kinase 26

1

20

High-throughput

0.437

High

451457

DIC
Mitochondrial dicarboxylate carrier

1

4

High-throughput

0.437

High

451458

CCD39
Coiled-coil domain-containing protein 39

1

20

High-throughput

0.437

High

451459

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

2

High-throughput

0.437

High

451462

RCOR1
REST corepressor 1

1

6

High-throughput

0.437

High

451463

SNX6
Sorting nexin-6

1

2

High-throughput

0.437

High

451465

AP3M1
AP-3 complex subunit mu-1

1

11

High-throughput

0.437

High

451467

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

1

10

High-throughput

0.437

High

451470

SETBP
SET-binding protein

1

1

High-throughput

0.437

High

87305

OSCRI
SCRIB overlapping open reading frame protein

1

4

High-throughput

0.407

High

344064

PTBP3
Polypyrimidine tract-binding protein 3

1

4

High-throughput

0.407

High

379191

IGHG1
Immunoglobulin heavy constant gamma 1

1

8

High-throughput

0.407

High

451315

CALM3
Calmodulin-3

1

2

High-throughput

0.407

High

451316

SCHI1
Schwannomin-interacting protein 1

1

1

High-throughput

0.407

High

451355

TERA
Transitional endoplasmic reticulum ATPase

1

11

High-throughput

0.407

High

451413

POC5
Centrosomal protein POC5

1

4

High-throughput

0.407

High

451414

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.407

High

451435

CEP63
Centrosomal protein of 63 kDa

1

20

High-throughput

0.407

High

451464

ITM2B
Integral membrane protein 2B

1

16

High-throughput

0.407

High

451466

KLDC2
Kelch domain-containing protein 2

1

9

High-throughput

0.407

High

451441

CC106
Coiled-coil domain-containing protein 106

3

0

High-throughput

0.347

High

451427

FBXW5
F-box/WD repeat-containing protein 5

3

0

High-throughput

0.345

High

451361

SMD2
Small nuclear ribonucleoprotein Sm D2

2

0

High-throughput

0.305

High

442543

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.301

High

451446

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.279

Low

251843

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

0

High-throughput

0.249

Low

276988

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.249

Low

451333

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

451336

CALR
Calreticulin

1

0

High-throughput

0.249

Low

451337

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.249

Low

451338

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.249

Low

451360

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.249

Low

451366

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.249

Low

451397

NU188
Nucleoporin NUP188

1

0

High-throughput

0.249

Low

451412

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.249

Low

451433

MRP9
ATP-binding cassette sub-family C member 12

1

0

High-throughput

0.249

Low

451439

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.249

Low

391722

STAT
Statherin

1

0

High-throughput

0.232

Low

451406

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025