Protein: THRB
Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]

Gene: THRB, F2
Organism: Homo sapiens
Interactions: 46
UniProt ID: P00734

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0001934 - positive regulation of protein phosphorylation
GO:0004252 - serine-type endopeptidase activity
GO:0005102 - signaling receptor binding
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341129

TRBM
Thrombomodulin

4

18

Small-scale

0.888

High

341115

FA10
Coagulation factor X

2

16

Small-scale

0.768

High

341117

ANT3
Antithrombin-III

2

20

Small-scale

0.768

High

341124

A4
Amyloid-beta precursor protein

1

17

High-throughput

0.665

High

341125

PAI1
Plasminogen activator inhibitor 1

1

20

Small-scale

0.647

High

341126

IPSP
Plasma serine protease inhibitor

1

20

Small-scale

0.647

High

341127

IC1
Plasma protease C1 inhibitor

1

20

Small-scale

0.647

High

341138

SPB6
Serpin B6

1

20

Small-scale

0.647

High

341149

CBPB2
Carboxypeptidase B2

1

3

Small-scale

0.647

High

341120

FIBG
Fibrinogen gamma chain

1

8

Small-scale

0.618

High

341136

1433T
14-3-3 protein theta

2

3

High-throughput

0.601

High

341116

TPA
Tissue-type plasminogen activator

1

15

Small-scale

0.575

High

341119

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

8

Small-scale

0.575

High

341128

HEP2
Heparin cofactor 2

1

20

Small-scale

0.575

High

182990

P2RX6
P2X purinoceptor 6

1

2

High-throughput

0.536

High

341122

ALBU
Albumin

1

4

High-throughput

0.536

High

341134

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

341137

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.536

High

341142

INHBE
Inhibin beta E chain

1

5

High-throughput

0.536

High

341139

DDIT3
DNA damage-inducible transcript 3 protein

1

0

High-throughput

0.518

High

336800

FA8
Coagulation factor VIII

1

10

Small-scale

0.501

High

341130

TSP1
Thrombospondin-1

1

11

Small-scale

0.501

High

341131

ITA2B
Integrin alpha-IIb

1

6

Small-scale

0.501

High

341132

TAU
Microtubule-associated protein tau

1

3

Small-scale

0.501

High

341133

FA5
Coagulation factor V

1

10

Small-scale

0.501

High

341135

PAR1
Proteinase-activated receptor 1

1

5

Small-scale

0.501

High

341141

F10A1
Hsc70-interacting protein

1

2

Small-scale

0.501

High

341146

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

6

High-throughput

0.489

High

341150

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

1

High-throughput

0.489

High

341151

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

3

High-throughput

0.489

High

341144

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.484

High

341118

APOC3
Apolipoprotein C-III

1

1

High-throughput

0.479

High

341121

FINC
Fibronectin

1

10

Small-scale

0.479

High

341123

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

341145

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

341147

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

341152

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

341155

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

226203

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.437

High

260418

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

341143

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.437

High

341153

TRI31
E3 ubiquitin-protein ligase TRIM31

1

3

High-throughput

0.437

High

341154

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

341140

CAMP
Cathelicidin antimicrobial peptide

1

1

Small-scale

0.408

High

233134

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

341148

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024