HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	F-box-like~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 229 Hs			1 424
+	Hs
		475101 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		FXL16_HUMAN (34-378): 2.42e-47: 170: 19.95
+	At
		1210483 UBQ10_ARATH (1-228): 2.81e-91: 277: 96.05		BRL2_ARATH (130-424): 4.29e-34: 137: 16.56
+	Dm
		1365167 Q9W418_DROME (1-228): 2.1e-92: 282: 100.00		Q9VF10_DROME (133-392): 4.51e-31: 127: 19.40
+	Hs
		475187 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		FXL15_HUMAN (85-361): 7.41e-25: 105: 21.28
+	At
		1092449 UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43		BRL2_ARATH (130-424): 4.29e-34: 137: 16.56
+	Hs
		476369 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		FXL15_HUMAN (85-361): 7.41e-25: 105: 21.28
+	At
		1092125 UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43		BRL3_ARATH (133-424): 8.32e-22: 100: 13.78
+	Zm
		22950 A0A1D6I4G6_MAIZE (2-76): 1.38e-23: 95.1: 61.33		K7UXB8_MAIZE (63-388): 5.62e-16: 81.4: 17.90