HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: EPN3 (Q9H201)
Epsin-3 (EPS-15-interacting protein 3)
Gene: EPN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	UIM~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 632
+	Sc
		477505 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		ENT1_YEAST (3-211): 2.58e-63: 217: 36.36
+	Hs
		476358 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		EPN3_HUMAN (1-632): 1.32e-92: 300: 100.00
+	Hs
		111209 RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00		I6L9I8_HUMAN (1-316): 1.19e-106: 326: 94.30
+	Sc
		477449 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		ENT2_YEAST (3-213): 5.86e-52: 191: 31.28
+	Dm
		1182371 R9PY16_DROME (1-220): 3.01e-86: 259: 91.82		Q7KU90_DROME (1-622): 4.26e-51: 191: 26.90
+	Hs
		924159 RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00		EPN3_HUMAN (1-632): 1.32e-92: 300: 100.00
+	Mm
		476910 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		EPN2_MOUSE (1-632): 2.89e-67: 232: 35.75
+	Rn
		291394 UBC_RAT (1-181): 2.6e-61: 206: 96.13		EPN1_RAT (1-592): 3.86e-59: 209: 37.38
+	Mm
		476869 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		EPN1_MOUSE (1-592): 7.73e-58: 206: 36.72
+	Hs
		307500 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		EPN2_HUMAN (1-632): 5.11e-66: 229: 33.54
+	Hs
		476657 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		EPN1_HUMAN (1-592): 3.16e-57: 204: 37.64
+	Hs
		307522 RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00		EPN2_HUMAN (1-632): 5.11e-66: 229: 33.54
+	Mm
		476700 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		EPS15_MOUSE (38-558): 2.8e-43: 169: 10.11
+	Dm
		477525 UBIQP_DROME (1-154): 5.32e-53: 183: 99.35		Q7KU90_DROME (1-622): 4.26e-51: 191: 26.90
+	Rn
		1144063 UBC_RAT (1-181): 2.6e-61: 206: 96.13		SYNJ1_RAT (43-625): 1.84e-39: 157: 11.17
+	Hs
		475452 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		EPS15_HUMAN (38-569): 4e-46: 177: 10.26
+	At
		1091714 UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43		EPN2_ARATH (2-617): 1.36e-45: 175: 20.51
+	Rn
		1126748 UBC_RAT (1-181): 2.6e-61: 206: 96.13		Q5JC29_RAT (38-494): 8.65e-36: 145: 10.68
+	Hs
		924231 RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00		EPN1_HUMAN (1-592): 3.16e-57: 204: 37.64
+	At
		1092229 UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43		SC24C_ARATH (262-575): 2.13e-09: 62.8: 14.97