Protein: NCPR
NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4)

Gene: NCPR, POR
Organism: Homo sapiens
Interactions: 178
UniProt ID: P16435

Gene Ontology (top 5):
GO:0003958 - NADPH-hemoprotein reductase activity
GO:0004128 - cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0006805 - xenobiotic metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

548310

CP2C9
Cytochrome P450 2C9

3

6

Small-scale

0.840

High

425993

CP2E1
Cytochrome P450 2E1

3

6

Small-scale

0.840

High

425983

CP1A2
Cytochrome P450 1A2

2

7

Small-scale

0.778

High

596610

CP2CJ
Cytochrome P450 2C19

2

5

Small-scale

0.778

High

596707

UBXN6
UBX domain-containing protein 6

4

1

High-throughput

0.694

High

596631

SC61B
Protein transport protein Sec61 subunit beta

3

1

High-throughput

0.656

High

475183

CP3A4
Cytochrome P450 3A4

1

4

Small-scale

0.647

High

528932

CP2D6
Cytochrome P450 2D6

1

6

Small-scale

0.647

High

547306

CP2A6
Cytochrome P450 2A6

1

6

Small-scale

0.647

High

129982

PGRC1
Membrane-associated progesterone receptor component 1

2

4

Small-scale

0.635

High

596735

SNX8
Sorting nexin-8

3

0

High-throughput

0.634

High

596599

NCPR
NADPH--cytochrome P450 reductase

1

10

Small-scale

0.621

High

417250

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

1

High-throughput

0.611

High

417935

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

2

High-throughput

0.611

High

596626

BAP31
B-cell receptor-associated protein 31

2

1

High-throughput

0.611

High

596704

DERL1
Derlin-1

2

2

High-throughput

0.611

High

596629

SYRC
Arginine--tRNA ligase, cytoplasmic

2

0

High-throughput

0.602

High

596659

EMC4
ER membrane protein complex subunit 4

2

0

High-throughput

0.585

High

596641

FANCC
Fanconi anemia group C protein

1

1

Small-scale

0.581

High

596734

SRPRB
Signal recognition particle receptor subunit beta

2

1

High-throughput

0.571

High

596607

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.547

High

181250

PGRC2
Membrane-associated progesterone receptor component 2

1

4

High-throughput

0.536

High

477397

CD63
CD63 antigen

1

3

High-throughput

0.536

High

596606

CALX
Calnexin

1

1

High-throughput

0.536

High

596611

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.536

High

596650

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

2

High-throughput

0.536

High

596651

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.536

High

596672

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

3

High-throughput

0.536

High

596695

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

596705

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.536

High

596710

DERL2
Derlin-2

1

2

High-throughput

0.536

High

596717

RTN4
Reticulon-4

1

3

High-throughput

0.536

High

596725

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

105271

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

596627

CAV2
Caveolin-2

2

4

High-throughput

0.521

High

596712

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.515

High

270886

CLAP2
CLIP-associating protein 2

1

0

High-throughput

0.513

High

468988

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.513

High

505129

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.513

High

596622

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

596636

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.513

High

596683

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.513

High

596685

F241A
Uncharacterized protein FAM241A

1

0

High-throughput

0.513

High

596690

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

596670

RABEK
Rab9 effector protein with kelch motifs

1

5

High-throughput

0.508

High

596640

CYC
Cytochrome c

1

1

Small-scale

0.501

High

596609

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.489

High

596615

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

3

High-throughput

0.481

High

48516

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.479

High

126456

RHOD
Rho-related GTP-binding protein RhoD

1

16

High-throughput

0.479

High

173848

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

5

High-throughput

0.479

High

178176

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

240673

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

337933

CNEP1
CTD nuclear envelope phosphatase 1

1

1

High-throughput

0.479

High

373758

RASN
GTPase NRas

1

3

High-throughput

0.479

High

375149

RASK
GTPase KRas

1

2

High-throughput

0.479

High

403801

GCR
Glucocorticoid receptor

1

4

Small-scale

0.479

High

411306

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

425295

ISG15
Ubiquitin-like protein ISG15

1

3

High-throughput

0.479

High

466095

RHOC
Rho-related GTP-binding protein RhoC

1

14

High-throughput

0.479

High

580862

RAC2
Ras-related C3 botulinum toxin substrate 2

1

14

High-throughput

0.479

High

596600

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

596603

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.479

High

596612

CEAM6
Cell adhesion molecule CEACAM6

1

2

High-throughput

0.479

High

596614

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

596617

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.479

High

596618

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

4

Small-scale

0.479

High

596623

EMD
Emerin

1

2

High-throughput

0.479

High

596624

RAB7A
Ras-related protein Rab-7a

1

6

High-throughput

0.479

High

596625

RAB9A
Ras-related protein Rab-9A

1

5

High-throughput

0.479

High

596628

RND2
Rho-related GTP-binding protein RhoN

1

16

High-throughput

0.479

High

596630

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

596632

RAC3
Ras-related C3 botulinum toxin substrate 3

1

14

High-throughput

0.479

High

596633

CDC42
Cell division control protein 42 homolog

1

14

High-throughput

0.479

High

596635

RHOA
Transforming protein RhoA

1

15

High-throughput

0.479

High

596637

RAC1
Ras-related C3 botulinum toxin substrate 1

1

14

High-throughput

0.479

High

596639

RHOG
Rho-related GTP-binding protein RhoG

1

14

High-throughput

0.479

High

596643

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

596644

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.479

High

596647

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.479

High

596648

CUL3
Cullin-3

1

1

High-throughput

0.479

High

596654

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

596674

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.479

High

596677

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

596687

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

596688

RN149
E3 ubiquitin-protein ligase RNF149

1

3

High-throughput

0.479

High

596696

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

596697

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

596701

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

596703

ESYT1
Extended synaptotagmin-1

1

3

High-throughput

0.479

High

596709

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

596714

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

596715

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

596716

RHOF
Rho-related GTP-binding protein RhoF

1

16

High-throughput

0.479

High

596721

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.479

High

596722

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.479

High

596727

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

596729

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

596730

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

596731

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.479

High

156925

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

164242

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

192441

INSI1
Insulin-induced gene 1 protein

1

0

Small-scale

0.458

High

222696

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

596613

ARL1
ADP-ribosylation factor-like protein 1

1

0

High-throughput

0.458

High

596621

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

596645

STX4
Syntaxin-4

1

0

High-throughput

0.458

High

596646

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

596649

SAFB2
Scaffold attachment factor B2

1

0

High-throughput

0.458

High

596653

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

596656

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

596661

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

596665

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

596675

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.458

High

596676

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

596684

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

596691

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.458

High

596713

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

596719

ANLN
Anillin

1

0

High-throughput

0.458

High

596720

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

596724

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

596726

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

557835

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.457

High

211111

CTR4
Cationic amino acid transporter 4

1

4

High-throughput

0.445

High

303215

S22A5
Organic cation/carnitine transporter 2

1

2

High-throughput

0.445

High

596608

CTR1
High affinity cationic amino acid transporter 1

1

4

High-throughput

0.445

High

596616

EAA1
Excitatory amino acid transporter 1

1

3

High-throughput

0.445

High

596619

S6A12
Sodium- and chloride-dependent betaine transporter

1

4

High-throughput

0.445

High

596620

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

4

High-throughput

0.445

High

596652

MFS10
Major facilitator superfamily domain-containing protein 10

1

3

High-throughput

0.445

High

596666

ZNT10
Calcium/manganese antiporter SLC30A10

1

1

High-throughput

0.445

High

596680

S35F2
Solute carrier family 35 member F2

1

2

High-throughput

0.445

High

596686

MFSD9
Major facilitator superfamily domain-containing protein 9

1

3

High-throughput

0.445

High

596689

S7A14
Solute carrier family 7 member 14

1

4

High-throughput

0.445

High

596694

S35B4
Nucleotide sugar transporter SLC35B4

1

1

High-throughput

0.445

High

596700

SL9A7
Sodium/hydrogen exchanger 7

1

2

High-throughput

0.445

High

596706

S12A9
Solute carrier family 12 member 9

1

4

High-throughput

0.445

High

227358

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.437

High

596601

RAB3B
Ras-related protein Rab-3B

1

2

High-throughput

0.437

High

596602

RAB4A
Ras-related protein Rab-4A

1

2

High-throughput

0.437

High

596638

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

596655

RHOH
Rho-related GTP-binding protein RhoH

1

15

High-throughput

0.437

High

596658

BCORL
BCL-6 corepressor-like protein 1

1

1

High-throughput

0.437

High

596663

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

596667

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

596669

BT2A1
Butyrophilin subfamily 2 member A1

1

4

High-throughput

0.437

High

596671

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

596692

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

596699

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

596723

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

137352

NPT4
Sodium-dependent phosphate transport protein 4

1

0

High-throughput

0.426

High

255971

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

529014

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

538729

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

0

High-throughput

0.426

High

596662

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

596664

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.426

High

596681

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.426

High

596708

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

596711

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

596728

S23A2
Solute carrier family 23 member 2

1

0

High-throughput

0.426

High

596660

S35F1
Solute carrier family 35 member F1

1

2

High-throughput

0.407

High

596678

S22A9
Organic anion transporter 7

1

2

High-throughput

0.407

High

596693

CTR3
Cationic amino acid transporter 3

1

4

High-throughput

0.407

High

596604

MATN1
Matrilin-1

1

0

High-throughput

0.279

Low

596634

FGF12
Fibroblast growth factor 12

1

0

High-throughput

0.279

Low

596698

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

596732

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

596733

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

596642

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

596668

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

596673

LBN
Limbin

1

0

High-throughput

0.249

Low

596679

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

596682

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

596605

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

596657

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low

596702

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.232

Low

596718

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025