HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBE2A (P49459)
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Gene: UBE2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	25582440, 27182664, 34642328
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 152
+	Hs
		476604 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D4_HUMAN (5-149): 1.13e-78: 231: 40.69
+	Hs
		475501 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D1_HUMAN (5-149): 5.04e-78: 229: 40.00
+	Hs
		475586 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62
+	Hs
		475550 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D3_HUMAN (5-149): 1.9e-76: 225: 38.62
+	Hs
		475597 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2B_HUMAN (1-151): 3.28e-74: 219: 96.03
+	Hs
		476218 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E2_HUMAN (3-150): 6.19e-73: 218: 35.14
+	Hs
		476155 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E3_HUMAN (3-150): 2.3e-72: 217: 35.14
+	Hs
		475504 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E1_HUMAN (3-150): 5.05e-71: 213: 36.49
+	Xl
		919927 Q7SY79_XENLA (77-685): 0: 744: 99.84		UB2D2_XENLA (5-149): 7.73e-78: 229: 38.62
+	Dm
		639414 Q9W418_DROME (229-685): 0: 557: 99.78		UBCD1_DROME (5-149): 2.91e-77: 227: 38.62
+	Sc
		477103 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC4_YEAST (1-149): 1.43e-77: 228: 36.91
+	Sc
		410203 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC2_YEAST (1-150): 2.29e-73: 218: 69.33
+	At
		1091932 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC28_ARATH (5-149): 1.16e-78: 231: 41.38
+	At
		715116 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC8_ARATH (5-149): 3.75e-78: 230: 40.69
+	At
		715132 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC9_ARATH (5-149): 1.11e-77: 228: 41.38
+	At
		715147 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC10_ARATH (5-149): 1.01e-77: 228: 41.38
+	At
		715157 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC11_ARATH (5-149): 1.51e-77: 228: 39.31
+	At
		639385 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC1_ARATH (1-150): 1.31e-73: 218: 76.67
+	At
		790155 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC2_ARATH (1-150): 1.51e-73: 218: 76.00
+	At
		1092130 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC19_ARATH (7-144): 1.12e-36: 125: 47.10