Protein: UBP3
Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3)

Gene: UBP3, USP3
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q9Y6I4

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508925

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

8

20

Small-scale

0.964

High

1327628

WDTC1
WD and tetratricopeptide repeats protein 1

2

13

High-throughput

0.811

High

350201

SNAI1
Zinc finger protein SNAI1

3

5

Small-scale

0.664

High

1453349

SACS
Sacsin

1

0

High-throughput

0.656

High

639421

5NTD
5'-nucleotidase

2

3

High-throughput

0.628

High

762377

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

2

1

High-throughput

0.628

High

154914

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

4

High-throughput

0.609

High

1461880

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

Small-scale

0.578

High

345135

RIGI
Antiviral innate immune response receptor RIG-I

1

14

Small-scale

0.561

High

414935

P53
Cellular tumor antigen p53

1

4

Small-scale

0.561

High

1419405

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

12

Small-scale

0.561

High

1438534

ABC3G
DNA dC->dU-editing enzyme APOBEC-3G

1

1

Small-scale

0.561

High

1212250

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

4

High-throughput

0.558

High

163202

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.554

High

295265

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

3

High-throughput

0.536

High

720900

KPYR
Pyruvate kinase PKLR

1

1

High-throughput

0.536

High

799643

GNAL
Guanine nucleotide-binding protein G(olf) subunit alpha

1

1

High-throughput

0.536

High

1121936

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

4

High-throughput

0.536

High

1231747

NXN
Nucleoredoxin

1

1

High-throughput

0.536

High

295413

CBR3
Carbonyl reductase [NADPH] 3

1

0

High-throughput

0.513

High

1125953

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

0

High-throughput

0.513

High

1120083

CO9A3

1

1

Small-scale

0.512

High

175492

RIMB2
RIMS-binding protein 2

1

2

High-throughput

0.489

High

188072

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

4

High-throughput

0.489

High

939476

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

10

High-throughput

0.489

High

1060943

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

High-throughput

0.489

High

1102937

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

12

High-throughput

0.489

High

1206591

PRC2B
Protein PRRC2B

1

7

High-throughput

0.489

High

1405794

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.489

High

131543

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

4

High-throughput

0.479

High

373648

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

419295

H2A1B
Histone H2A type 1-B/E

1

15

Small-scale

0.479

High

719191

MPIP1
M-phase inducer phosphatase 1

1

2

Small-scale

0.479

High

755046

H2B1B
Histone H2B type 1-B

1

19

Small-scale

0.479

High

769651

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

980632

H4
Histone H4

1

2

High-throughput

0.479

High

981208

H2B1C
Histone H2B type 1-C/E/F/G/I

1

19

High-throughput

0.479

High

999013

H31
Histone H3.1

1

4

High-throughput

0.479

High

1005302

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1017339

H33
Histone H3.3

1

4

High-throughput

0.479

High

1033835

PO5F1
POU domain, class 5, transcription factor 1

1

2

Small-scale

0.479

High

1047159

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

5

High-throughput

0.479

High

1089082

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

1118802

KLF5
Krueppel-like factor 5

1

4

Small-scale

0.479

High

1137617

SUZ12
Polycomb protein SUZ12

1

1

Small-scale

0.479

High

1292897

STING
Stimulator of interferon genes protein

1

4

Small-scale

0.479

High

1367713

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

1459501

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1491433

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

1095331

REST
RE1-silencing transcription factor

1

0

Small-scale

0.458

High

1384839

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

437851

HEPS
Serine protease hepsin

1

2

High-throughput

0.445

High

848846

MAGAA
Melanoma-associated antigen 10

1

2

High-throughput

0.445

High

71072

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

3

High-throughput

0.437

High

75503

B3KSH1
Eukaryotic translation initiation factor 3 subunit F

1

4

High-throughput

0.407

High

325453

O95065
Eucaryotic translation initiation factor 4G isoform 1

1

2

High-throughput

0.407

High

1416618

Q9BX72
Eukaryotic translation initiation factor 3 subunit F

1

4

High-throughput

0.407

High

71974

CO6A5
Collagen alpha-5(VI) chain

1

0

Small-scale

0.292

High

187826

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.279

Low

1433291

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.279

Low

1432223

SPNS1
Protein spinster homolog 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025