HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UB2G2 (P60604)
Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)
Gene: UBE2G2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	27182664, 32296183, 21098018, 16214370, unassigned1304
Identification Methods	proximity labelling technology, two hybrid, x-ray crystallography, pull down, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 165
+	Hs
		476604 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03
+	Hs
		475501 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03
+	Hs
		475586 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03
+	Hs
		475550 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78
+	Hs
		475597 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2B_HUMAN (1-162): 5.98e-71: 212: 38.89
+	Hs
		475573 UBC_HUMAN (1-685): 0: 846: 100.00		UB2G1_HUMAN (4-164): 2.51e-69: 208: 50.00
+	Hs
		475485 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2A_HUMAN (1-162): 1.72e-67: 203: 38.89
+	Hs
		475959 UBC_HUMAN (1-685): 0: 846: 100.00		UB2R2_HUMAN (4-158): 9.21e-45: 149: 50.00
+	Hs
		475483 UBC_HUMAN (1-685): 0: 846: 100.00		UB2R1_HUMAN (4-159): 1.54e-43: 145: 49.08
+	Xl
		919927 Q7SY79_XENLA (77-685): 0: 744: 99.84		UB2D2_XENLA (4-164): 5.65e-73: 217: 36.03
+	Dm
		639414 Q9W418_DROME (229-685): 0: 557: 99.78		UBCD1_DROME (4-164): 1.2e-72: 216: 34.78
+	Sc
		477103 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC4_YEAST (1-163): 4.52e-71: 212: 31.90
+	Sc
		477415 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC7_YEAST (1-165): 3.95e-70: 210: 62.42
+	Sc
		477098 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC3_YEAST (4-162): 3.31e-37: 130: 44.79
+	At
		715116 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC8_ARATH (4-164): 3.16e-73: 218: 36.03
+	At
		715132 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC9_ARATH (4-164): 8.38e-73: 217: 36.03
+	Sc
		410203 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC2_YEAST (1-162): 1.08e-33: 118: 37.65
+	At
		715147 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC10_ARATH (4-164): 1.29e-72: 216: 35.40
+	At
		715157 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC11_ARATH (4-164): 1.85e-72: 216: 35.40
+	At
		639385 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC1_ARATH (1-162): 3.16e-35: 121: 38.27