Protein: K1C10
Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)

Gene: K1C10, KRT10
Organism: Homo sapiens
Interactions: 194
UniProt ID: P13645

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

407375

K2C1
Keratin, type II cytoskeletal 1

2

20

Small-scale

0.828

High

341731

K2C75
Keratin, type II cytoskeletal 75

1

20

High-throughput

0.618

High

385229

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.618

High

407245

K2C6B
Keratin, type II cytoskeletal 6B

1

20

High-throughput

0.618

High

436781

K1C18
Keratin, type I cytoskeletal 18

1

20

High-throughput

0.618

High

437075

K2C8
Keratin, type II cytoskeletal 8

1

20

High-throughput

0.618

High

474439

VIME
Vimentin

1

20

High-throughput

0.618

High

475509

K1C19
Keratin, type I cytoskeletal 19

1

20

High-throughput

0.618

High

475738

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.618

High

566093

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.618

High

566095

DESM
Desmin

1

20

High-throughput

0.618

High

566107

K22E
Keratin, type II cytoskeletal 2 epidermal

1

20

High-throughput

0.618

High

566110

PERI
Peripherin

1

20

High-throughput

0.618

High

566136

K22O
Keratin, type II cytoskeletal 2 oral

1

20

High-throughput

0.618

High

566137

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.618

High

566222

KRT84
Keratin, type II cuticular Hb4

1

20

High-throughput

0.618

High

566147

CUL3
Cullin-3

2

20

High-throughput

0.611

High

566170

RICTR
Rapamycin-insensitive companion of mTOR

2

6

Small-scale

0.611

High

566096

VCAM1
Vascular cell adhesion protein 1

2

7

High-throughput

0.601

High

566232

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.584

High

566104

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

Small-scale

0.573

High

563096

CFTR
Cystic fibrosis transmembrane conductance regulator

2

20

Small-scale

0.571

High

566209

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

20

High-throughput

0.571

High

388976

FINC
Fibronectin

1

8

High-throughput

0.536

High

389947

ALBU
Albumin

1

9

High-throughput

0.536

High

566139

ZO1
Tight junction protein 1

1

7

Small-scale

0.536

High

566145

CUL1
Cullin-1

1

20

High-throughput

0.536

High

566146

CUL2
Cullin-2

1

20

High-throughput

0.536

High

566148

CUL4A
Cullin-4A

1

20

High-throughput

0.536

High

566149

CUL4B
Cullin-4B

1

20

High-throughput

0.536

High

566152

FL2D
Pre-mRNA-splicing regulator WTAP

1

9

High-throughput

0.536

High

566155

NEDD8
Ubiquitin-like protein NEDD8

1

8

High-throughput

0.536

High

566178

CSN6
COP9 signalosome complex subunit 6

1

13

High-throughput

0.536

High

566179

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

15

High-throughput

0.536

High

566180

TLK2
Serine/threonine-protein kinase tousled-like 2

1

12

High-throughput

0.536

High

566181

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

8

High-throughput

0.536

High

566188

RIN3
Ras and Rab interactor 3

1

3

High-throughput

0.536

High

566193

CSN5
COP9 signalosome complex subunit 5

1

20

High-throughput

0.536

High

566194

CUL5
Cullin-5

1

20

High-throughput

0.536

High

566200

DCNL1
DCN1-like protein 1

1

4

High-throughput

0.536

High

566219

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

15

High-throughput

0.536

High

557056

SRC
Proto-oncogene tyrosine-protein kinase Src

1

8

Small-scale

0.515

High

566101

DPP4
Dipeptidyl peptidase 4

1

3

High-throughput

0.515

High

566138

KPCZ
Protein kinase C zeta type

1

11

Small-scale

0.515

High

470253

NEP
Neprilysin

1

0

Small-scale

0.513

High

185395

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

395411

ESR1
Estrogen receptor

1

16

Small-scale

0.501

High

566128

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

9

Small-scale

0.501

High

566189

MIPT3
TRAF3-interacting protein 1

1

2

Small-scale

0.489

High

566133

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

11

High-throughput

0.484

High

333292

SNAPN
SNARE-associated protein Snapin

1

7

High-throughput

0.481

High

566163

GLE1
mRNA export factor GLE1

1

14

Small-scale

0.481

High

131311

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

13

Small-scale

0.479

High

136278

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.479

High

141305

DDX3X
ATP-dependent RNA helicase DDX3X

1

8

Small-scale

0.479

High

187276

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

12

High-throughput

0.479

High

209461

SERA
D-3-phosphoglycerate dehydrogenase

1

9

Small-scale

0.479

High

240624

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.479

High

277265

PITX3
Pituitary homeobox 3

1

7

Small-scale

0.479

High

293136

CD123
Translation initiation factor eIF2 assembly protein

1

14

High-throughput

0.479

High

297432

PIAS1
E3 SUMO-protein ligase PIAS1

1

3

High-throughput

0.479

High

302355

RNF8
E3 ubiquitin-protein ligase RNF8

1

16

High-throughput

0.479

High

319355

UFL1
E3 UFM1-protein ligase 1

1

3

High-throughput

0.479

High

323143

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

324480

HEXI1
Protein HEXIM1

1

20

High-throughput

0.479

High

334985

ARI2
E3 ubiquitin-protein ligase ARIH2

1

20

High-throughput

0.479

High

352911

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.479

High

362681

EGFR
Epidermal growth factor receptor

1

12

High-throughput

0.479

High

371051

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

377939

TNFA
Tumor necrosis factor

1

5

High-throughput

0.479

High

378948

PIGR
Polymeric immunoglobulin receptor

1

1

Small-scale

0.479

High

405743

MYCN
N-myc proto-oncogene protein

1

15

High-throughput

0.479

High

413103

P53
Cellular tumor antigen p53

1

9

Small-scale

0.479

High

442988

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

5

Small-scale

0.479

High

458261

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.479

High

482294

F16P1
Fructose-1,6-bisphosphatase 1

1

7

High-throughput

0.479

High

484885

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

14

High-throughput

0.479

High

521181

ARAF
Serine/threonine-protein kinase A-Raf

1

7

High-throughput

0.479

High

565117

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

566094

TIMP2
Metalloproteinase inhibitor 2

1

10

High-throughput

0.479

High

566097

BTF3
Transcription factor BTF3

1

4

High-throughput

0.479

High

566099

CBL
E3 ubiquitin-protein ligase CBL

1

12

High-throughput

0.479

High

566102

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

566103

EF1D
Elongation factor 1-delta

1

3

Small-scale

0.479

High

566105

1433S
14-3-3 protein sigma

1

17

Small-scale

0.479

High

566106

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

566108

ARL3
ADP-ribosylation factor-like protein 3

1

12

High-throughput

0.479

High

566109

IF4A3
Eukaryotic initiation factor 4A-III

1

17

High-throughput

0.479

High

566111

EPS15
Epidermal growth factor receptor substrate 15

1

18

High-throughput

0.479

High

566112

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

566115

ARL4D
ADP-ribosylation factor-like protein 4D

1

13

High-throughput

0.479

High

566116

CDK9
Cyclin-dependent kinase 9

1

6

High-throughput

0.479

High

566117

MECP2
Methyl-CpG-binding protein 2

1

9

High-throughput

0.479

High

566121

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.479

High

566122

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

13

High-throughput

0.479

High

566124

MGN
Protein mago nashi homolog

1

5

High-throughput

0.479

High

566125

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

14

High-throughput

0.479

High

566126

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.479

High

566127

H31
Histone H3.1

1

4

High-throughput

0.479

High

566130

ARF1
ADP-ribosylation factor 1

1

8

High-throughput

0.479

High

566131

ARF5
ADP-ribosylation factor 5

1

8

High-throughput

0.479

High

566132

H33
Histone H3.3

1

4

High-throughput

0.479

High

566134

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

3

High-throughput

0.479

High

566135

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

566141

ARL16
ADP-ribosylation factor-like protein 16

1

15

High-throughput

0.479

High

566143

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.479

High

566150

DX39B
Spliceosome RNA helicase DDX39B

1

20

Small-scale

0.479

High

566151

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.479

High

566153

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

10

High-throughput

0.479

High

566154

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

20

High-throughput

0.479

High

566156

EZH2
Histone-lysine N-methyltransferase EZH2

1

16

High-throughput

0.479

High

566158

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.479

High

566160

LARP7
La-related protein 7

1

17

High-throughput

0.479

High

566161

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

9

High-throughput

0.479

High

566162

MIDN
Midnolin

1

3

High-throughput

0.479

High

566164

EMC4
ER membrane protein complex subunit 4

1

5

High-throughput

0.479

High

566167

OTU1
Ubiquitin thioesterase OTU1

1

10

High-throughput

0.479

High

566168

VIR
Protein virilizer homolog

1

6

High-throughput

0.479

High

566169

PRP8
Pre-mRNA-processing-splicing factor 8

1

11

High-throughput

0.479

High

566172

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

8

High-throughput

0.479

High

566173

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

566177

MEPCE
7SK snRNA methylphosphate capping enzyme

1

16

High-throughput

0.479

High

566183

RHG24
Rho GTPase-activating protein 24

1

7

High-throughput

0.479

High

566187

TNIP2
TNFAIP3-interacting protein 2

1

8

High-throughput

0.479

High

566190

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.479

High

566191

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

14

High-throughput

0.479

High

566192

HDAC2
Histone deacetylase 2

1

16

High-throughput

0.479

High

566195

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

566196

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

9

Small-scale

0.479

High

566197

DCPS
m7GpppX diphosphatase

1

3

High-throughput

0.479

High

566198

AP2M1
AP-2 complex subunit mu

1

9

High-throughput

0.479

High

566199

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

High-throughput

0.479

High

566202

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

566203

NECD
Necdin

1

7

High-throughput

0.479

High

566205

ACE2
Angiotensin-converting enzyme 2

1

9

High-throughput

0.479

High

566206

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

10

High-throughput

0.479

High

566207

TRI31
E3 ubiquitin-protein ligase TRIM31

1

20

High-throughput

0.479

High

566210

DDX24
ATP-dependent RNA helicase DDX24

1

20

High-throughput

0.479

High

566212

RN208
RING finger protein 208

1

20

Small-scale

0.479

High

566213

ATG5
Autophagy protein 5

1

6

High-throughput

0.479

High

566214

GAN
Gigaxonin

1

12

High-throughput

0.479

High

566215

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

16

Small-scale

0.479

High

566217

RC3H2
Roquin-2

1

20

High-throughput

0.479

High

566218

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

566220

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

15

High-throughput

0.479

High

566221

ANLN
Anillin

1

13

High-throughput

0.479

High

566223

RNF12
E3 ubiquitin-protein ligase RLIM

1

20

High-throughput

0.479

High

566225

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

566226

HDAC6
Protein deacetylase HDAC6

1

20

High-throughput

0.479

High

566227

KS6B2
Ribosomal protein S6 kinase beta-2

1

9

High-throughput

0.479

High

566228

ZRAN1
Ubiquitin thioesterase ZRANB1

1

16

High-throughput

0.479

High

566229

FBXL4
F-box/LRR-repeat protein 4

1

2

Small-scale

0.479

High

566230

FAF1
FAS-associated factor 1

1

3

High-throughput

0.479

High

566233

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

14

Small-scale

0.479

High

377388

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

566118

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.458

High

566142

MN1
Transcriptional activator MN1

1

0

Small-scale

0.458

High

566157

CRY1
Cryptochrome-1

1

0

High-throughput

0.458

High

566204

RNF26
E3 ubiquitin-protein ligase RNF26

1

2

Small-scale

0.457

High

294657

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

High-throughput

0.445

High

327772

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.445

High

379205

IGHG1
Immunoglobulin heavy constant gamma 1

1

13

High-throughput

0.445

High

379612

IGHA1
Immunoglobulin heavy constant alpha 1

1

13

High-throughput

0.445

High

528976

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

566123

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

566140

LG3BP
Galectin-3-binding protein

1

11

High-throughput

0.445

High

566144

CTBP1
C-terminal-binding protein 1

1

9

High-throughput

0.445

High

566165

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

566182

SULF2
Extracellular sulfatase Sulf-2

1

12

High-throughput

0.445

High

566211

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

566216

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

High-throughput

0.445

High

105233

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

566098

EFNA1
Ephrin-A1

1

20

High-throughput

0.437

High

566114

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

566119

EFNA3
Ephrin-A3

1

20

High-throughput

0.437

High

566120

EFNA4
Ephrin-A4

1

20

High-throughput

0.437

High

566159

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

4

Small-scale

0.437

High

566166

RC3H1
Roquin-1

1

14

High-throughput

0.437

High

566171

LRC31
Leucine-rich repeat-containing protein 31

1

12

High-throughput

0.437

High

566175

ASXL2
Putative Polycomb group protein ASXL2

1

6

High-throughput

0.437

High

566176

KCTD9
BTB/POZ domain-containing protein KCTD9

1

16

High-throughput

0.437

High

566184

ARL10
ADP-ribosylation factor-like protein 10

1

15

High-throughput

0.437

High

566185

FNDC5
Fibronectin type III domain-containing protein 5

1

1

Small-scale

0.437

High

566201

DIRA2
GTP-binding protein Di-Ras2

1

3

Small-scale

0.437

High

566208

ASXL3
Putative Polycomb group protein ASXL3

1

4

High-throughput

0.437

High

566224

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

5

High-throughput

0.437

High

566231

AAR2
Protein AAR2 homolog

1

7

High-throughput

0.437

High

566234

INSI2
Insulin-induced gene 2 protein

1

3

High-throughput

0.437

High

566113

RS9
Small ribosomal subunit protein uS4

1

0

Small-scale

0.426

High

566129

SMAD3
Mothers against decapentaplegic homolog 3

1

0

Small-scale

0.426

High

910

SIM26
Small integral membrane protein 26

1

6

High-throughput

0.407

High

566100

HEMH
Ferrochelatase, mitochondrial

1

5

High-throughput

0.407

High

566174

NEK10
Serine/threonine-protein kinase Nek10

1

7

High-throughput

0.407

High

566186

MOT11
Monocarboxylate transporter 11

1

5

High-throughput

0.407

High


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Last updated: 11Aug2025