HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RNF4 (P78317)
E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF)
Gene: RNF4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	26148049, 32733036, 24714598
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 190
+	Hs
		475893 UBC_HUMAN (1-685): 0: 846: 100.00		BRE1A_HUMAN (23-190): 2.03e-24: 101: 19.89
+	Hs
		475927 UBC_HUMAN (1-685): 0: 846: 100.00		RFWD3_HUMAN (15-189): 1.45e-21: 93.2: 15.85
+	Hs
		476198 UBC_HUMAN (1-685): 0: 846: 100.00		RN185_HUMAN (126-189): 2.47e-20: 85.5: 31.34
+	Hs
		476078 UBC_HUMAN (1-685): 0: 846: 100.00		COP1_HUMAN (125-189): 3.88e-12: 65.8: 32.31
+	Hs
		475328 UBC_HUMAN (1-685): 0: 846: 100.00		RO52_HUMAN (120-187): 1.12e-11: 64.3: 34.78
+	Xl
		1140135 Q7SY79_XENLA (77-685): 0: 744: 99.84		Q5XGX4_XENLA (103-189): 1.43e-21: 88.6: 23.33
+	Dm
		1215068 Q9W418_DROME (229-685): 0: 557: 99.78		Q8IR26_DROME (106-189): 1.2e-21: 90.9: 26.44
+	Dm
		1368557 Q9W418_DROME (229-685): 0: 557: 99.78		Q9VJB0_DROME (99-190): 2e-21: 89.3: 26.09
+	Dm
		1375478 R9PY16_DROME (457-685): 5.07e-80: 258: 90.39		Q9VXP1_DROME (106-189): 4.33e-22: 92: 26.44
+	Dm
		1215070 R9PY16_DROME (457-685): 5.07e-80: 258: 90.39		Q8IR26_DROME (106-189): 1.2e-21: 90.9: 26.44
+	Xl
		1140130 Q6GMC1_XENLA (609-684): 7.23e-41: 148: 100.00		Q5XGX4_XENLA (103-189): 1.43e-21: 88.6: 23.33
+	Hs
		924117 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		RN185_HUMAN (126-189): 2.47e-20: 85.5: 31.34
+	Mm
		476848 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN220_MOUSE (70-190): 8.67e-23: 96.7: 22.31
+	Mm
		476948 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN185_MOUSE (95-189): 2.73e-21: 88.2: 22.45
+	Hs
		475137 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN185_HUMAN (126-189): 2.47e-20: 85.5: 31.34