HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: HERC4 (Q5GLZ8)
Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4)
Gene: HERC4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	38803224, 22496338
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 1057
+	Hs
		475785 UBC_HUMAN (1-685): 0: 846: 100.00		HERC3_HUMAN (1-1056): 0: 994: 55.91
+	Hs
		476350 UBC_HUMAN (1-685): 0: 846: 100.00		WWP1_HUMAN (413-1055): 0: 632: 20.87
+	Hs
		125113 UBC_HUMAN (1-685): 0: 846: 100.00		WWP2_HUMAN (374-1055): 0: 619: 20.66
+	Hs
		476205 UBC_HUMAN (1-685): 0: 846: 100.00		ITCH_HUMAN (480-1055): 0: 600: 21.48
+	Hs
		475470 UBC_HUMAN (1-685): 0: 846: 100.00		NEDD4_HUMAN (384-1055): 0: 572: 17.84
+	Hs
		476403 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF2_HUMAN (503-1054): 0: 572: 20.98
+	Hs
		476229 UBC_HUMAN (1-685): 0: 846: 100.00		NED4L_HUMAN (435-1055): 0: 567: 20.27
+	Hs
		475963 UBC_HUMAN (1-685): 0: 846: 100.00		HECW1_HUMAN (383-1056): 2.16e-177: 562: 20.79
+	Hs
		475652 UBC_HUMAN (1-685): 0: 846: 100.00		UBE3A_HUMAN (442-1057): 5.58e-173: 531: 29.50
+	Hs
		476414 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF1_HUMAN (609-1054): 1.18e-172: 526: 22.33
+	Dm
		89879 UBIQP_DROME (1-610): 0: 752: 99.84		D5SHR3_DROME (703-1056): 4.04e-152: 460: 29.24
+	Hs
		475811 UBC_HUMAN (1-685): 0: 846: 100.00		HERC1_HUMAN (151-598): 6.53e-62: 234: 21.49
+	Hs
		319697 UBC_HUMAN (1-685): 0: 846: 100.00		HERC2_HUMAN (4-157): 1.7e-12: 74.3: 30.63
+	Sc
		477293 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RSP5_YEAST (607-1055): 4.51e-175: 534: 25.88
+	At
		1091762 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UPL2_ARATH (450-1056): 3.56e-169: 554: 20.92
+	Hs
		924156 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WWP1_HUMAN (413-1055): 0: 632: 20.87
+	Hs
		125347 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WWP2_HUMAN (374-1055): 0: 619: 20.66
+	Sp
		143368 UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80		PTR1_SCHPO (707-1056): 2.96e-45: 181: 30.22
+	Sc
		477424 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		TOM1_YEAST (707-1056): 1.91e-49: 194: 32.23
+	Ce
		477557 UBIQ1_CAEEL (1-229): 5.97e-87: 292: 98.25		Q9GUP2_CAEEL (713-1056): 4.33e-46: 183: 30.90