Protein: GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)

Gene: GNAI2
Organism: Homo sapiens
Interactions: 243
UniProt ID: P04899

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0001973 - G protein-coupled adenosine receptor signaling pathway
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

418747

RIC8A
Chaperone Ric-8A

4

13

Small-scale

0.902

High

418571

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

4

12

High-throughput

0.892

High

418618

MTR1A
Melatonin receptor type 1A

3

20

Small-scale

0.866

High

418573

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

3

12

High-throughput

0.861

High

418649

GPSM2
G-protein-signaling modulator 2

3

14

Small-scale

0.857

High

418768

GPSM3
G-protein-signaling modulator 3

2

3

High-throughput

0.808

High

418621

MTR1B
Melatonin receptor type 1B

2

19

Small-scale

0.789

High

418603

CXCR5
C-X-C chemokine receptor type 5

2

13

Small-scale

0.789

High

418753

RIC8B
Chaperone Ric-8B

2

13

High-throughput

0.789

High

193876

RGS5
Regulator of G-protein signaling 5

2

20

Small-scale

0.768

High

418597

CXCR1
C-X-C chemokine receptor type 1

2

19

Small-scale

0.754

High

418645

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

2

11

High-throughput

0.754

High

418622

RGS19
Regulator of G-protein signaling 19

2

20

Small-scale

0.743

High

303098

RGS20
Regulator of G-protein signaling 20

1

20

High-throughput

0.740

High

418699

PCP2
Purkinje cell protein 2 homolog

2

11

High-throughput

0.700

High

418741

GBB4
Guanine nucleotide-binding protein subunit beta-4

4

20

Small-scale

0.696

High

418672

LT4R1
Leukotriene B4 receptor 1

1

16

Small-scale

0.692

High

418626

GBG10

4

20

High-throughput

0.691

High

418641

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

4

20

Small-scale

0.686

High

243462

GBG7

3

20

High-throughput

0.667

High

418584

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

3

20

High-throughput

0.667

High

418625

GBG4

3

20

High-throughput

0.667

High

418647

GBG5

3

20

High-throughput

0.667

High

418716

PAQR1
Adiponectin receptor protein 1

3

1

High-throughput

0.667

High

418756

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

3

1

High-throughput

0.667

High

192029

RGS16
Regulator of G-protein signaling 16

1

20

Small-scale

0.647

High

418567

ADRB2
Beta-2 adrenergic receptor

1

10

Small-scale

0.647

High

418572

ADA2A
Alpha-2A adrenergic receptor

1

12

Small-scale

0.647

High

418593

TA2R
Thromboxane A2 receptor

1

20

Small-scale

0.647

High

418624

RGS4
Regulator of G-protein signaling 4

1

20

Small-scale

0.647

High

418721

MRGX1
Mas-related G-protein coupled receptor member X1

1

20

Small-scale

0.647

High

418751

RGS18
Regulator of G-protein signaling 18

1

20

Small-scale

0.647

High

418579

CFTR
Cystic fibrosis transmembrane conductance regulator

3

4

High-throughput

0.643

High

418684

LMBD2
G-protein coupled receptor-associated protein LMBRD2

3

0

High-throughput

0.638

High

418745

ABCB6
ATP-binding cassette sub-family B member 6

3

0

High-throughput

0.638

High

418727

MDFI
MyoD family inhibitor

2

0

High-throughput

0.629

High

418646

GBG3

2

20

High-throughput

0.628

High

168028

RGS12
Regulator of G-protein signaling 12

1

20

Small-scale

0.621

High

220432

RGS14
Regulator of G-protein signaling 14

1

20

Small-scale

0.621

High

418642

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

2

20

Small-scale

0.619

High

168010

RGS13
Regulator of G-protein signaling 13

1

20

Small-scale

0.618

High

418565

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

11

High-throughput

0.618

High

418590

CNR1
Cannabinoid receptor 1

1

18

Small-scale

0.618

High

418598

PAR1
Proteinase-activated receptor 1

1

19

Small-scale

0.618

High

418602

AA1R
Adenosine receptor A1

1

12

Small-scale

0.618

High

418605

CRFR1
Corticotropin-releasing factor receptor 1

1

9

Small-scale

0.618

High

418612

OPRD
Delta-type opioid receptor

1

17

Small-scale

0.618

High

418614

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.618

High

418623

RGS3
Regulator of G-protein signaling 3

1

20

Small-scale

0.618

High

418740

ECT2
Protein ECT2

1

11

High-throughput

0.618

High

418633

CD81
CD81 antigen

2

8

Small-scale

0.612

High

418660

IQGA2
Ras GTPase-activating-like protein IQGAP2

2

11

High-throughput

0.611

High

418676

GRDN
Girdin

2

7

High-throughput

0.611

High

418717

ARL8A
ADP-ribosylation factor-like protein 8A

2

2

High-throughput

0.611

High

418707

MCU
Calcium uniporter protein, mitochondrial

3

1

High-throughput

0.609

High

418762

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

2

20

High-throughput

0.601

High

240472

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

370905

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.584

High

375079

RASK
GTPase KRas

2

12

High-throughput

0.584

High

418659

SQSTM
Sequestosome-1

2

3

High-throughput

0.584

High

418748

ANLN
Anillin

2

8

High-throughput

0.584

High

418592

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

15

Small-scale

0.575

High

418669

K1H1
Keratin, type I cuticular Ha1

1

1

High-throughput

0.573

High

418670

TRIP6
Thyroid receptor-interacting protein 6

1

1

High-throughput

0.573

High

418686

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.573

High

418655

DUS4
Dual specificity protein phosphatase 4

2

16

High-throughput

0.571

High

418668

KPCD1
Serine/threonine-protein kinase D1

2

8

High-throughput

0.571

High

418680

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

4

Small-scale

0.571

High

418665

RASA3
Ras GTPase-activating protein 3

1

15

Small-scale

0.561

High

418585

NCF2
Neutrophil cytosol factor 2

1

2

Small-scale

0.554

High

418634

KR108
Keratin-associated protein 10-8

1

0

High-throughput

0.549

High

418695

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.549

High

171387

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.536

High

339396

ACSL3
Fatty acid CoA ligase Acsl3

1

2

High-throughput

0.536

High

418570

HS90B
Heat shock protein HSP 90-beta

1

3

Small-scale

0.536

High

418576

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.536

High

418608

MYH9
Myosin-9

1

3

High-throughput

0.536

High

418615

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

1

High-throughput

0.536

High

418656

STK3
Serine/threonine-protein kinase 3

1

4

High-throughput

0.536

High

418661

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.536

High

418690

S27A4
Long-chain fatty acid transport protein 4

1

1

High-throughput

0.536

High

418698

PIM3
Serine/threonine-protein kinase pim-3

1

7

High-throughput

0.536

High

418702

SYNPO
Synaptopodin

1

2

High-throughput

0.536

High

418710

TBCK
TBC domain-containing protein kinase-like protein

1

4

High-throughput

0.536

High

418712

HASP
Serine/threonine-protein kinase haspin

1

4

High-throughput

0.536

High

418749

PDLI7
PDZ and LIM domain protein 7

1

1

High-throughput

0.536

High

418757

PAK5
Serine/threonine-protein kinase PAK 5

1

12

High-throughput

0.536

High

124567

EYA2
Protein phosphatase EYA2

1

5

Small-scale

0.527

High

180468

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

418566

NPM
Nucleophosmin

1

0

High-throughput

0.518

High

418726

TTC1
Tetratricopeptide repeat protein 1

1

7

Small-scale

0.515

High

418588

LMNB1
Lamin-B1

1

0

High-throughput

0.513

High

418604

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.513

High

418617

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

418671

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

418635

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.501

High

418720

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

2

Small-scale

0.501

High

166604

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

3

High-throughput

0.489

High

418591

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

5

Small-scale

0.481

High

418652

NUCB1
Nucleobindin-1

1

7

Small-scale

0.481

High

384354

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.480

High

136042

PLK4
Serine/threonine-protein kinase PLK4

1

4

Small-scale

0.479

High

164217

NRP1
Neuropilin-1

1

5

High-throughput

0.479

High

178142

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

188777

TMPS2
Transmembrane protease serine 2

1

4

High-throughput

0.479

High

217704

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

222630

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

228059

PM34
Peroxisomal membrane protein PMP34

1

4

High-throughput

0.479

High

247596

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

293045

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

318570

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.479

High

330562

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

341504

EYA4
Protein phosphatase EYA4

1

5

High-throughput

0.479

High

400097

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.479

High

405671

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

418568

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.479

High

418569

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

418574

FURIN
Furin

1

2

High-throughput

0.479

High

418575

IL8
Interleukin-8

1

1

Small-scale

0.479

High

418577

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.479

High

418578

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

418580

NCF1
Neutrophil cytosol factor 1

1

1

Small-scale

0.479

High

418581

BRAF
Serine/threonine-protein kinase B-raf

1

13

High-throughput

0.479

High

418582

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

418586

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

418587

ATP4A
Potassium-transporting ATPase alpha chain 1

1

6

Small-scale

0.479

High

418594

CBL
E3 ubiquitin-protein ligase CBL

1

3

Small-scale

0.479

High

418599

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.479

High

418600

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

High-throughput

0.479

High

418607

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

418609

BASI
Basigin

1

3

High-throughput

0.479

High

418610

BMR1A
Bone morphogenetic protein receptor type-1A

1

2

High-throughput

0.479

High

418611

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

418616

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

418619

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

418620

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

418627

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.479

High

418628

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

418629

PLK1
Serine/threonine-protein kinase PLK1

1

5

High-throughput

0.479

High

418632

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

20

Small-scale

0.479

High

418636

RAB2A
Ras-related protein Rab-2A

1

5

High-throughput

0.479

High

418637

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

418638

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

418640

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

418644

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

418651

KIF23
Kinesin-like protein KIF23

1

14

High-throughput

0.479

High

418653

VAC14
Protein VAC14 homolog

1

1

High-throughput

0.479

High

418654

TFCP2
Alpha-globin transcription factor CP2

1

8

High-throughput

0.479

High

418662

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

3

High-throughput

0.479

High

418663

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.479

High

418666

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

418673

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

418675

DUS6
Dual specificity protein phosphatase 6

1

16

High-throughput

0.479

High

418678

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.479

High

418679

MIDN
Midnolin

1

3

High-throughput

0.479

High

418683

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

High-throughput

0.479

High

418693

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

418694

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

418701

MILK2
MICAL-like protein 2

1

1

High-throughput

0.479

High

418703

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

418711

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

418715

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

418718

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

418719

OPTN
Optineurin

1

11

High-throughput

0.479

High

418724

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.479

High

418728

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

8

High-throughput

0.479

High

418729

DUS9
Dual specificity protein phosphatase 9

1

16

High-throughput

0.479

High

418730

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

418731

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

418734

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.479

High

418735

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

418736

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

418737

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

418738

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

418739

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

418742

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

418743

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

8

High-throughput

0.479

High

418750

DUS22
Dual specificity protein phosphatase 22

1

15

High-throughput

0.479

High

418752

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

418754

RNF12
E3 ubiquitin-protein ligase RLIM

1

6

High-throughput

0.479

High

418758

SYLC
Leucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

418759

GBG12

1

20

High-throughput

0.479

High

418760

HDAC6
Protein deacetylase HDAC6

1

7

High-throughput

0.479

High

418761

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

418764

RNF6
E3 ubiquitin-protein ligase RNF6

1

6

High-throughput

0.479

High

418766

CRYL1
Lambda-crystallin homolog

1

1

High-throughput

0.479

High

418767

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

378800

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.458

High

417883

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

418596

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

418601

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

418643

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

418658

S39A6
Zinc transporter ZIP6

1

0

High-throughput

0.458

High

418685

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

418689

RINT1
RAD50-interacting protein 1

1

0

High-throughput

0.458

High

418691

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.458

High

418697

NLRX1
NLR family member X1

1

0

High-throughput

0.458

High

418706

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

418709

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.458

High

418755

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.458

High

418763

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

0

High-throughput

0.458

High

418769

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

418648

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.457

High

211104

CTR4
Cationic amino acid transporter 4

1

2

High-throughput

0.445

High

254726

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

337057

NPT2B
Sodium-dependent phosphate transport protein 2B

1

3

High-throughput

0.445

High

418606

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

418613

S19A1
Reduced folate transporter

1

5

High-throughput

0.445

High

418630

MOT1
Monocarboxylate transporter 1

1

7

High-throughput

0.445

High

418631

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

418639

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.445

High

418650

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

418664

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

11

High-throughput

0.445

High

418677

S22A6
Solute carrier family 22 member 6

1

6

High-throughput

0.445

High

418687

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.445

High

418704

CD177
CD177 antigen

1

4

Small-scale

0.445

High

418714

CTL1
Choline transporter-like protein 1

1

6

High-throughput

0.445

High

418722

CEP63
Centrosomal protein of 63 kDa

1

7

High-throughput

0.445

High

418723

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

14

High-throughput

0.445

High

418725

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.445

High

418732

S19A3
Thiamine transporter 2

1

5

High-throughput

0.445

High

418733

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

418744

ANKH
Mineralization regulator ANKH

1

2

High-throughput

0.445

High

418746

SO1B3
Solute carrier organic anion transporter family member 1B3

1

4

High-throughput

0.445

High

418765

ITM2B
Integral membrane protein 2B

1

8

High-throughput

0.445

High

105104

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

352287

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.437

High

418583

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.437

High

418674

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.437

High

418713

RN138
E3 ubiquitin-protein ligase RNF138

1

4

High-throughput

0.437

High

418589

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

418657

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

418688

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

418692

S36A4
Neutral amino acid uniporter 4

1

0

High-throughput

0.426

High

418705

POC5
Centrosomal protein POC5

1

0

High-throughput

0.426

High

418595

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

418700

S22A9
Organic anion transporter 7

1

6

High-throughput

0.407

High

418708

MFSD8
Major facilitator superfamily domain-containing protein 8

1

6

High-throughput

0.407

High

418682

MFS4B
Sodium-dependent glucose transporter 1

3

0

High-throughput

0.347

High

418696

ADCK1
AarF domain-containing protein kinase 1

2

0

High-throughput

0.318

High

418667

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.269

Low

418681

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025