HitPredict

Interactor 1: A0A8V8TNS8 (A0A8V8TNS8)
SH3 domain containing kinase binding protein 1
Gene: SH3KBP1

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 427 Hs			1 906
+	Mm
		610651 CD2AP_MOUSE (1-402): 9.88e-61: 210: 38.74		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		208994 NCK2_HUMAN (240-422): 2.23e-22: 100: 19.79		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		557607 NCK1_HUMAN (270-418): 1.74e-21: 97.3: 17.61		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610415 ITSN1_HUMAN (1-127): 9.84e-18: 88.1: 25.20		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610517 ITSN2_HUMAN (1-128): 9.22e-18: 88.1: 22.66		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		610633 NCK1_MOUSE (270-418): 3.9e-21: 96.1: 17.61		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		610657 ITSN2_MOUSE (1-118): 1.04e-16: 85: 22.69		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		82738 NCK1_MOUSE (270-418): 3.9e-21: 96.1: 17.61		B9EKI5_MOUSE (23-901): 0: 799: 47.22
+	Hs
		209046 NCK2_HUMAN (240-422): 2.23e-22: 100: 19.79		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		557678 NCK1_HUMAN (270-418): 1.74e-21: 97.3: 17.61		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Mm
		223012 NCK2_MOUSE (240-422): 3.36e-21: 96.5: 20.86		CBLB_MOUSE (23-901): 0: 791: 45.98
+	Hs
		1027606 ITSN1_HUMAN (1-127): 9.84e-18: 88.1: 25.20		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		1027627 ITSN2_HUMAN (1-128): 9.22e-18: 88.1: 22.66		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Mm
		1112081 ITSN2_MOUSE (1-118): 1.04e-16: 85: 22.69		CBLB_MOUSE (23-901): 0: 791: 45.98
+	Dm
		112567 M9ND00_DROME (213-423): 2.26e-18: 90: 14.04		O46034_DROME (47-460): 0: 746: 70.84
+	Ce
		666220 SEM5_CAEEL (4-67): 2.79e-20: 91.1: 37.50		Q6ABG8_CAEEL (43-510): 0: 662: 48.24
+	Ce
		666213 SEM5_CAEEL (4-67): 2.79e-20: 91.1: 37.50		Q19019_CAEEL (49-546): 0: 639: 44.12
+	Hs
		203208 NCK1_HUMAN (270-418): 1.74e-21: 97.3: 17.61		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Hs
		203228 ITSN1_HUMAN (1-127): 9.84e-18: 88.1: 25.20		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Hs
		257713 ITSN2_HUMAN (1-128): 9.22e-18: 88.1: 22.66		ANR17_HUMAN (410-903): 9.9e-09: 61.5: 11.51