HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: M3K2 (Q9Y2U5)
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
Gene: MAP3K2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	36736316, 20588253
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 619
+	Hs
		476266 UBC_HUMAN (1-685): 0: 846: 100.00		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Hs
		475703 UBC_HUMAN (1-685): 0: 846: 100.00		M3K1_HUMAN (351-613): 5.82e-51: 192: 42.13
+	Hs
		476663 UBC_HUMAN (1-685): 0: 846: 100.00		M3K4_HUMAN (356-616): 2.34e-47: 181: 39.10
+	Hs
		1306392 Q9UFQ0_HUMAN (295-533): 4.21e-87: 274: 99.58		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Hs
		924221 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		M3K2_HUMAN (1-619): 0: 590: 100.00
+	Hs
		475248 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		M3K2_HUMAN (1-619): 0: 590: 100.00
+	Hs
		924126 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	At
		1091641 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		KIN10_ARATH (355-619): 4.11e-132: 398: 31.84
+	At
		955189 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		KIN11_ARATH (355-619): 1.99e-129: 391: 31.46
+	Hs
		475158 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Rn
		1144164 UBC_RAT (1-108): 1.27e-29: 127: 90.74		PAK2_RAT (106-617): 5.24e-123: 375: 24.13
+	Hs
		474936 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		AKT2_HUMAN (297-616): 5.53e-125: 379: 26.30
+	Hs
		475017 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		M3K1_HUMAN (351-613): 5.82e-51: 192: 42.13