HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP3 (Q9Y6I4)
Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3)
Gene: USP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.964

Property	Details
Experiments	28190767, 29576527, 33141564, 17980597, 34642328, 36114200, 38803224, 10480896
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UCH~ubiquitin, ubiquitin~zf-UBP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 520
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (26-511): 1.15e-117: 358: 27.20
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (82-516): 3.57e-111: 344: 30.32
+	Hs
		475440 UBC_HUMAN (1-685): 0: 846: 100.00		UBP8_HUMAN (50-517): 1.53e-105: 342: 27.20
+	Hs
		476400 UBC_HUMAN (1-685): 0: 846: 100.00		UBP42_HUMAN (60-520): 2.32e-99: 328: 23.59
+	Hs
		476545 UBC_HUMAN (1-685): 0: 846: 100.00		UBP21_HUMAN (117-516): 2.18e-104: 325: 28.57
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (97-520): 2.37e-102: 316: 28.36
+	Hs
		476493 UBC_HUMAN (1-685): 0: 846: 100.00		UBP36_HUMAN (98-519): 1.5e-94: 312: 25.06
+	Hs
		475566 UBC_HUMAN (1-685): 0: 846: 100.00		UBP46_HUMAN (133-512): 1.79e-98: 303: 26.77
+	Hs
		259261 UBC_HUMAN (1-685): 0: 846: 100.00		UBP12_HUMAN (121-512): 1.13e-97: 301: 26.72
+	Hs
		475932 UBC_HUMAN (1-685): 0: 846: 100.00		U17L2_HUMAN (91-519): 6.03e-94: 297: 22.56
+	Dm
		477538 UBIQP_DROME (1-610): 0: 752: 99.84		NOT_DROME (27-510): 2.88e-106: 328: 25.92
+	Hs
		476097 UBC_HUMAN (1-685): 0: 846: 100.00		UBP33_HUMAN (3-277): 2.05e-21: 100: 28.77
+	Hs
		475693 UBC_HUMAN (1-685): 0: 846: 100.00		UBP4_HUMAN (160-345): 5.47e-16: 83.2: 29.74
+	At
		1210479 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		UBP15_ARATH (97-519): 1.08e-90: 298: 25.12
+	Sc
		477366 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP8_YEAST (28-513): 9.52e-93: 292: 25.69
+	At
		1092065 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBP15_ARATH (97-519): 1.08e-90: 298: 25.12
+	Mm
		476865 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP8_MOUSE (50-517): 3.44e-105: 340: 27.41
+	Hs
		924201 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		UBP36_HUMAN (98-519): 1.5e-94: 312: 25.06
+	Mm
		476741 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP46_MOUSE (133-512): 1.79e-98: 303: 26.77
+	Mm
		476695 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP4_MOUSE (160-345): 1.75e-16: 84.7: 29.74