HitPredict

Interactor 1: UBC (P0CG50)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]
Gene: UBC

Interactor 2: IKKA (Q60680)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
Gene: Chuk

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	28190767
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 734 Mm			1 745
+	Mm
		291435 UBC_MOUSE (1-734): 0: 912: 100.00		IKKB_MOUSE (1-743): 0: 600: 48.73
+	Hs
		167451 UBC_HUMAN (77-724): 0: 790: 97.22		IKKA_HUMAN (1-745): 0: 600: 95.44
+	Hs
		158377 UBC_HUMAN (77-724): 0: 790: 97.22		IKKB_HUMAN (1-743): 0: 597: 49.93
+	Mm
		477048 UBC_MOUSE (1-734): 0: 912: 100.00		IKKE_MOUSE (15-721): 1.01e-139: 429: 20.00
+	Hs
		476524 UBC_HUMAN (77-724): 0: 790: 97.22		TBK1_HUMAN (15-679): 2.12e-122: 384: 19.52
+	Hs
		475745 UBC_HUMAN (77-724): 0: 790: 97.22		IKKE_HUMAN (15-730): 3.98e-121: 381: 19.50
+	Hs
		475345 UBC_HUMAN (77-724): 0: 790: 97.22		KS6B1_HUMAN (6-447): 1.58e-112: 352: 18.66
+	Mm
		250791 UBC_MOUSE (1-734): 0: 912: 100.00		ULK1_MOUSE (7-221): 2.6e-30: 130: 34.06
+	Rn
		250479 UBC_RAT (1-724): 0: 898: 97.51		KCC1B_RAT (15-287): 3.01e-24: 106: 29.20
+	Hs
		262227 UBC_HUMAN (77-724): 0: 790: 97.22		ULK1_HUMAN (7-221): 8.6e-30: 128: 34.06
+	At
		1091642 UBQ3_ARATH (457-724): 7.39e-99: 308: 89.55		CDPKB_ARATH (5-475): 1.6e-128: 393: 18.24
+	At
		1091633 UBQ3_ARATH (457-724): 7.39e-99: 308: 89.55		CDPK5_ARATH (7-485): 9.84e-124: 382: 17.94
+	At
		1091646 UBQ3_ARATH (457-724): 7.39e-99: 308: 89.55		MPK4_ARATH (18-353): 1.44e-123: 376: 21.74
+	At
		1091641 UBQ3_ARATH (457-724): 7.39e-99: 308: 89.55		KIN10_ARATH (14-482): 2.25e-112: 351: 20.09
+	Hs
		625332 RS27A_HUMAN (609-684): 3.67e-42: 152: 100.00		CDK2_HUMAN (12-312): 3.75e-126: 379: 22.98
+	Hs
		475222 UBB_HUMAN (1-77): 3.45e-27: 112: 98.70		TBK1_HUMAN (15-679): 2.12e-122: 384: 19.52
+	At
		1259032 P4KG4_ARATH (235-423): 6.92e-19: 92.9: 33.16		CDPKD_ARATH (8-508): 2.39e-125: 386: 16.25
+	Hs
		474936 UBB_HUMAN (1-77): 3.45e-27: 112: 98.70		AKT2_HUMAN (4-367): 1.28e-110: 346: 21.62