HitPredict

Interactor 1: UBA6 (A0AVT1)
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)
Gene: UBA6

Interactor 2: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.942

Property	Details
Experiments	29643511, 19250909, 28134249, 17580310, 36758106, 17597759
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1052 Hs			1 147
+	Hs
		48104 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		48106 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		607190 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20
+	Hs
		607026 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		607050 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00
+	Hs
		607039 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		607136 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73
+	Hs
		607129 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43
+	Hs
		607028 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73
+	Hs
		607023 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2A_HUMAN (2-144): 1.41e-70: 210: 39.16
+	Hs
		607054 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2B_HUMAN (2-144): 5.71e-70: 209: 37.76
+	Hs
		607042 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22
+	Sp
		293848 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC4_SCHPO (1-147): 1.21e-80: 236: 84.35
+	Sc
		549788 UBA1_YEAST (24-1046): 0: 979: 40.52		UBC4_YEAST (3-147): 1.04e-79: 233: 80.00
+	Sp
		251976 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC1_SCHPO (4-146): 6.92e-45: 147: 45.83
+	Sp
		293851 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC14_SCHPO (8-146): 5.28e-43: 140: 47.14
+	Dm
		715098 Q8T0L3_DROME (21-1045): 0: 990: 40.89		UBE2N_DROME (4-147): 8.8e-45: 145: 49.31
+	Hs
		782203 UBA7_HUMAN (34-1045): 0: 905: 36.34		UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73
+	Hs
		1282360 SAE2_HUMAN (49-418): 1.82e-78: 272: 13.64		UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43
+	Hs
		919796 UBA3_HUMAN (852-1017): 4.6e-40: 156: 19.19		UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00