HitPredict

Interactor 1: ESYT2 (A0FGR8)
Extended synaptotagmin-2 (E-Syt2) (Chr2Syt)
Gene: ESYT2

Interactor 2: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 37931956
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0045296 - cadherin binding GO:0061817 - endoplasmic reticulum-plasma membrane tethering
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 921 Hs			1 243
+	Hs
		48545 ESYT2_HUMAN (1-921): 0: 839: 100.00		VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30
+	Hs
		48429 ESYT2_HUMAN (1-921): 0: 839: 100.00		MSPD2_HUMAN (4-182): 2.15e-38: 141: 25.41
+	Hs
		310779 ESYT1_HUMAN (528-920): 4.27e-24: 111: 15.23		VAPB_HUMAN (1-243): 2.23e-87: 260: 100.00
+	Hs
		1311435 ESYT1_HUMAN (528-920): 4.27e-24: 111: 15.23		VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30
+	Sc
		767992 TCB1_YEAST (471-634): 1.05e-14: 80.8: 16.37		SCS2_YEAST (8-221): 1.47e-36: 130: 22.03
+	Sc
		767965 TCB3_YEAST (536-919): 2.64e-11: 70: 12.33		SCS2_YEAST (8-221): 1.47e-36: 130: 22.03