Protein: ITSN2
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)

Gene: ITSN2
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q9NZM3

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363943

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.884

High

1453435

SPN90
NCK-interacting protein with SH3 domain

3

3

High-throughput

0.855

High

896907

DYN2
Dynamin-2

3

12

High-throughput

0.821

High

1060697

SOS1
Son of sevenless homolog 1

2

16

High-throughput

0.791

High

508739

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

13

High-throughput

0.778

High

1292588

FCSD1
F-BAR and double SH3 domains protein 1

2

19

Small-scale

0.757

High

1090375

EPS8
Epidermal growth factor receptor kinase substrate 8

1

18

Small-scale

0.740

High

1051330

KPCZ
Protein kinase C zeta type

2

9

High-throughput

0.737

High

1453438

EP15R
Epidermal growth factor receptor substrate 15-like 1

5

18

High-throughput

0.713

High

1386724

AP2M1
AP-2 complex subunit mu

3

8

High-throughput

0.667

High

842666

WASP
Actin nucleation-promoting factor WAS

2

20

Small-scale

0.633

High

1144889

RABE1
Rab GTPase-binding effector protein 1

2

5

Small-scale

0.633

High

144027

P3C2B
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

1

5

High-throughput

0.621

High

274251

ANR17
Ankyrin repeat domain-containing protein 17

1

7

High-throughput

0.621

High

299586

TRIO
Triple functional domain protein

1

19

High-throughput

0.621

High

319248

FCSD2
F-BAR and double SH3 domains protein 2

1

20

High-throughput

0.621

High

1060722

SOS2
Son of sevenless homolog 2

1

12

High-throughput

0.621

High

1087320

STX4
Syntaxin-4

1

2

High-throughput

0.621

High

1154182

ITSN1
Intersectin-1

1

18

High-throughput

0.621

High

1384281

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.621

High

1408380

SH3G1
Endophilin-A2

1

20

High-throughput

0.621

High

1453434

ITSN2
Intersectin-2

1

16

High-throughput

0.621

High

1059983

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

6

Small-scale

0.620

High

269623

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

7

Small-scale

0.618

High

541723

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

641273

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.618

High

648704

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

710527

EPHA2
Ephrin type-A receptor 2

1

17

High-throughput

0.618

High

1242428

RHGBA
Rho GTPase-activating protein 11A

1

15

High-throughput

0.618

High

1453440

UBQL2
Ubiquilin-2

1

11

High-throughput

0.618

High

989144

AP2B1
AP-2 complex subunit beta

2

20

High-throughput

0.611

High

922616

AP2S1
AP-2 complex subunit sigma

2

9

High-throughput

0.601

High

1145408

RNPS1
RNA-binding protein with serine-rich domain 1

2

8

High-throughput

0.601

High

176277

SYNJ2
Synaptojanin-2

2

9

Small-scale

0.595

High

869523

TNFL6
Tumor necrosis factor ligand superfamily member 6

2

1

Small-scale

0.594

High

1128850

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.589

High

839838

EPS15
Epidermal growth factor receptor substrate 15

2

16

High-throughput

0.586

High

1411787

LARP6
La-related protein 6

2

2

High-throughput

0.586

High

397094

ESR1
Estrogen receptor

2

19

High-throughput

0.571

High

1251967

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.553

High

1400426

LMTK3
Serine/threonine-protein kinase LMTK3

1

20

High-throughput

0.553

High

1308752

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

8

High-throughput

0.541

High

733451

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

1083329

AP1B1
AP-1 complex subunit beta-1

1

20

High-throughput

0.536

High

1116068

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.536

High

1243784

FXL19
F-box/LRR-repeat protein 19

1

2

High-throughput

0.536

High

1347881

RIN3
Ras and Rab interactor 3

1

13

High-throughput

0.536

High

1410830

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

16

High-throughput

0.536

High

1434415

RNF41
E3 ubiquitin-protein ligase NRDP1

1

9

High-throughput

0.536

High

1435526

GARE1
GRB2-associated and regulator of MAPK protein 1

1

3

High-throughput

0.536

High

636775

PTN
Pleiotrophin

1

0

High-throughput

0.518

High

1453437

BCCIP
BRCA2 and CDKN1A-interacting protein

1

0

High-throughput

0.518

High

1097958

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

High-throughput

0.515

High

1234629

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

1453448

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

1431731

SEM6A
Semaphorin-6A

1

4

Small-scale

0.508

High

1439272

K1549
UPF0606 protein KIAA1549

1

4

Small-scale

0.508

High

209914

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

8

Small-scale

0.501

High

1085723

TBL3
Transducin beta-like protein 3

1

7

High-throughput

0.494

High

1155837

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.489

High

1418748

YTHD1
YTH domain-containing family protein 1

1

0

High-throughput

0.486

High

67436

GOG8A
Golgin subfamily A member 8A

1

10

High-throughput

0.481

High

133694

WASL
Actin nucleation-promoting factor WASL

1

16

High-throughput

0.481

High

154403

DLGP1
Disks large-associated protein 1

1

5

High-throughput

0.481

High

219565

WIPF1
WAS/WASL-interacting protein family member 1

1

10

High-throughput

0.481

High

281109

TACC1
Transforming acidic coiled-coil-containing protein 1

1

5

High-throughput

0.481

High

343492

SNP29
Synaptosomal-associated protein 29

1

5

High-throughput

0.481

High

369558

ANGT
Angiotensinogen

1

6

High-throughput

0.481

High

651445

CBL
E3 ubiquitin-protein ligase CBL

1

20

High-throughput

0.481

High

794651

RBMX
RNA-binding motif protein, X chromosome

1

2

High-throughput

0.481

High

879553

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.481

High

883067

AMPH
Amphiphysin

1

7

High-throughput

0.481

High

965923

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

4

High-throughput

0.481

High

1010882

TMF1
TATA element modulatory factor

1

6

High-throughput

0.481

High

1040391

DYST
Dystonin

1

17

High-throughput

0.481

High

1106309

ROCK1
Rho-associated protein kinase 1

1

6

High-throughput

0.481

High

1132349

GOGB1
Golgin subfamily B member 1

1

9

High-throughput

0.481

High

1218029

MYOME
Myomegalin

1

6

High-throughput

0.481

High

1256681

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

2

High-throughput

0.481

High

1307209

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

10

High-throughput

0.481

High

1324542

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

2

High-throughput

0.481

High

1353774

WIPF2
WAS/WASL-interacting protein family member 2

1

9

High-throughput

0.481

High

1357015

PDC6I
Programmed cell death 6-interacting protein

1

8

High-throughput

0.481

High

1387118

REPS1
RalBP1-associated Eps domain-containing protein 1

1

18

High-throughput

0.481

High

1388871

HOOK2
Protein Hook homolog 2

1

14

High-throughput

0.481

High

1403361

RUFY1
RUN and FYVE domain-containing protein 1

1

13

High-throughput

0.481

High

1432564

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

11

High-throughput

0.481

High

1453436

DAPLE
Protein Daple

1

14

High-throughput

0.481

High

1453449

WASF2
Actin-binding protein WASF2

1

6

High-throughput

0.481

High

65447

WIPF3
WAS/WASL-interacting protein family member 3

1

13

Small-scale

0.479

High

218878

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

386312

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

18

High-throughput

0.479

High

404485

GCR
Glucocorticoid receptor

1

19

High-throughput

0.479

High

483238

CLCA
Clathrin light chain A

1

10

High-throughput

0.479

High

483407

CLCB
Clathrin light chain B

1

10

High-throughput

0.479

High

540719

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.479

High

582994

EZRI
Ezrin

1

10

High-throughput

0.479

High

630065

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

786896

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

High-throughput

0.479

High

832378

OPRD
Delta-type opioid receptor

1

1

Small-scale

0.479

High

906610

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

4

High-throughput

0.479

High

1141981

EEA1
Early endosome antigen 1

1

5

High-throughput

0.479

High

1153129

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

2

High-throughput

0.479

High

1227596

A16L1
Autophagy-related protein 16-1

1

14

High-throughput

0.479

High

1287839

PABP2
Polyadenylate-binding protein 2

1

3

High-throughput

0.479

High

1336863

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

6

High-throughput

0.479

High

1353151

FBF1
Fas-binding factor 1

1

20

High-throughput

0.479

High

1356411

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

10

High-throughput

0.479

High

1387605

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

14

High-throughput

0.479

High

1391197

BICD1
Protein bicaudal D homolog 1

1

6

High-throughput

0.479

High

1439103

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

9

High-throughput

0.479

High

1451074

RBM22
Pre-mRNA-splicing factor RBM22

1

2

High-throughput

0.479

High

1453439

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1453444

MYO6
Unconventional myosin-VI

1

10

High-throughput

0.479

High

1453446

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

8

High-throughput

0.479

High

1453447

NINL
Ninein-like protein

1

11

High-throughput

0.479

High

344572

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

1

High-throughput

0.464

High

661895

IP3KA
Inositol-trisphosphate 3-kinase A

1

0

High-throughput

0.460

High

791783

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

890066

PSN1
Presenilin-1

1

0

High-throughput

0.460

High

1133860

GPNMB
Transmembrane glycoprotein NMB

1

0

High-throughput

0.460

High

1160327

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.460

High

1216490

AHDC1
Transcription factor Gibbin

1

0

High-throughput

0.460

High

1447998

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.460

High

1453441

CHIC2
Cysteine-rich hydrophobic domain-containing protein 2

1

0

High-throughput

0.460

High

464296

FUMH
Fumarate hydratase, mitochondrial

1

0

High-throughput

0.458

High

1390175

MCRS1
Microspherule protein 1

1

0

High-throughput

0.458

High

1447779

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

1237986

Q6NSK7
RIN3 protein

1

11

High-throughput

0.457

High

1396023

MEG10
Multiple epidermal growth factor-like domains protein 10

1

2

Small-scale

0.457

High

619942

VCAM1
Vascular cell adhesion protein 1

1

5

High-throughput

0.445

High

1453443

CBLC
E3 ubiquitin-protein ligase CBL-C

1

20

High-throughput

0.445

High

246995

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.439

High

330522

LC7L3
Luc7-like protein 3

1

3

High-throughput

0.439

High

605533

SYN1
Synapsin-1

1

9

High-throughput

0.439

High

888680

YLPM1
YLP motif-containing protein 1

1

6

High-throughput

0.439

High

1063658

GOGA2
Golgin subfamily A member 2

1

5

High-throughput

0.439

High

1217923

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

7

High-throughput

0.439

High

1260357

GARE2
GRB2-associated and regulator of MAPK protein 2

1

18

High-throughput

0.439

High

1325487

FNBP4
Formin-binding protein 4

1

1

High-throughput

0.439

High

471937

RU2B
U2 small nuclear ribonucleoprotein B''

1

2

High-throughput

0.437

High

521986

H14
Histone H1.4

1

1

High-throughput

0.437

High

888573

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.437

High

1276343

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.437

High

1276886

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1337426

SRFB1
Serum response factor-binding protein 1

1

1

High-throughput

0.437

High

1367443

ESR2
Estrogen receptor beta

1

19

High-throughput

0.437

High

1453445

UTP16
U3 small nucleolar RNA-associated protein NOL7

1

1

High-throughput

0.437

High

261298

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

1364118

TM9S4
Transmembrane 9 superfamily member 4

1

0

High-throughput

0.279

Low

1418212

RM09
Large ribosomal subunit protein bL9m

1

0

High-throughput

0.279

Low

1410539

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.251

Low

1370759

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

0

High-throughput

0.249

Low

1453442

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025