HitPredict

Interactor 1: CRB (P10040)
Protein crumbs (95F)
Gene: CRB

Interactor 2: EXPA (Q07436)
Protein expanded
Gene: ex

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	24778256, 20498073
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001745 - compound eye morphogenesis GO:0005886 - plasma membrane GO:0016327 - apicolateral plasma membrane GO:0035332 - positive regulation of hippo signaling GO:0046621 - negative regulation of organ growth
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 2146 Dm			1 1427
+	Dm
		49536 CRB_DROME (1-2146): 0: 884: 100.00		A0T1Z5_DROME (16-852): 1.03e-101: 345: 11.15
+	Dm
		484984 CRB_DROME (1-2146): 0: 884: 100.00		MOEH_DROME (26-636): 1.2e-93: 316: 14.81
+	Hs
		946793 CRUM1_HUMAN (459-685): 3.36e-10: 67.8: 23.79		E41L5_HUMAN (15-805): 3.27e-115: 381: 12.02
+	Hs
		1126606 CRUM2_HUMAN (586-759): 5.44e-09: 64: 29.94		E41L5_HUMAN (15-805): 3.27e-115: 381: 12.02
+	Dm
		422941 NOTCH_DROME (165-606): 5.1e-25: 116: 21.48		Q9W0R3_DROME (11-724): 1.2e-93: 327: 12.81
+	Hs
		640088 CRUM1_HUMAN (459-685): 3.36e-10: 67.8: 23.79		MOES_HUMAN (26-636): 1.98e-112: 368: 15.63
+	Hs
		547016 NOTC2_HUMAN (187-700): 1.2e-28: 128: 21.91		EZRI_HUMAN (24-689): 1.61e-89: 305: 12.05
+	Hs
		980545 NOTC2_HUMAN (187-700): 1.2e-28: 128: 21.91		E41LA_HUMAN (31-800): 9.26e-88: 303: 13.56
+	Hs
		946792 CRUM1_HUMAN (459-685): 3.36e-10: 67.8: 23.79		E41LB_HUMAN (11-881): 8.13e-100: 343: 13.40
+	Dm
		706641 FAT_DROME (97-303): 8.1e-12: 73.5: 12.88		EPB41_DROME (1-822): 6.73e-93: 333: 12.88
+	Dm
		706599 FAT_DROME (97-303): 8.1e-12: 73.5: 12.88		MOEH_DROME (26-636): 1.2e-93: 316: 14.81
+	Hs
		724388 FBN2_HUMAN (1391-2118): 2.56e-23: 111: 12.88		FRMD6_HUMAN (39-426): 3.42e-78: 273: 23.88