HitPredict

Interactor 1: GLI2 (P10070)
Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein)
Gene: GLI2

Interactor 2: GLI3 (P10071)
Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)]
Gene: GLI3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.646

The method score is based on:

Property Details
Experiments 35140242
Identification Methods affinity chromatography technology
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains zf-C2H2~zf-C2H2
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001649 - osteoblast differentiation
GO:0003700 - DNA-binding transcription factor activity
and 23 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1586
Hs

1 1580
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024