HitPredict

Interactor 1: RAP2A (P10114)
Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30)
Gene: RAP2A

Interactor 2: RPGF6 (Q8TEU7)
Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)
Gene: RAPGEF6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	11524421, 33961781
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PDZ~Ras, RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030033 - microvillus assembly GO:0072659 - protein localization to plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 1601
+	Hs
		919653 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF6_HUMAN (1-1601): 0: 1379: 100.00
+	Dm
		442976 RAP1_DROME (1-165): 8.23e-81: 239: 64.24		Q9VMF3_DROME (737-1277): 2.7e-89: 323: 36.68
+	Hs
		486052 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RGL1_HUMAN (653-1303): 8.15e-86: 300: 15.27
+	Hs
		919681 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RGL1_HUMAN (653-1303): 8.15e-86: 300: 15.27
+	Hs
		897964 RAP1B_HUMAN (1-182): 4.24e-79: 234: 60.66		RGL1_HUMAN (653-1303): 8.15e-86: 300: 15.27
+	Hs
		897984 RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21		RPGF1_HUMAN (587-1112): 1.46e-76: 279: 17.36
+	Hs
		919625 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF1_HUMAN (587-1112): 1.46e-76: 279: 17.36
+	Hs
		897981 RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21		GNDS_HUMAN (832-1097): 7.88e-72: 262: 19.67
+	Hs
		486024 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		GNDS_HUMAN (832-1097): 7.88e-72: 262: 19.67
+	Hs
		919618 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		GNDS_HUMAN (832-1097): 7.88e-72: 262: 19.67
+	Hs
		897883 RAP1B_HUMAN (1-182): 4.24e-79: 234: 60.66		GNDS_HUMAN (832-1097): 7.88e-72: 262: 19.67
+	Hs
		313164 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RPGF3_HUMAN (6-145): 1.03e-39: 162: 24.50
+	Hs
		313171 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF3_HUMAN (6-145): 1.03e-39: 162: 24.50
+	Hs
		313169 RAP1B_HUMAN (1-182): 4.24e-79: 234: 60.66		RPGF3_HUMAN (6-145): 1.03e-39: 162: 24.50
+	Hs
		486045 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RPGF5_HUMAN (413-508): 3.9e-18: 92.1: 22.12
+	Hs
		919657 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF5_HUMAN (413-508): 3.9e-18: 92.1: 22.12
+	Hs
		486043 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RPGF4_HUMAN (255-376): 1.78e-12: 74.7: 22.48
+	Hs
		919656 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF4_HUMAN (255-376): 1.78e-12: 74.7: 22.48
+	Hs
		897996 RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21		RPGF2_HUMAN (9-152): 6.41e-11: 69.7: 17.65
+	Hs
		919687 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF2_HUMAN (9-152): 6.41e-11: 69.7: 17.65