HitPredict

Interactor 1: CCL3 (P10147)
C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]
Gene: CCL3

Interactor 2: CCR3 (P51677)
C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)
Gene: CCR3

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	7622448
Identification Methods	biochemical
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0005737 - cytoplasm GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0019722 - calcium-mediated signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 92 Hs			1 355
+	Hs
		486230 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Hs
		561728 CL3L1_HUMAN (1-92): 2.12e-35: 117: 94.62		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Mm
		500591 CCL3_MOUSE (1-92): 6.45e-34: 113: 74.19		CCR3_MOUSE (9-355): 3.86e-90: 276: 70.03
+	Hs
		526560 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Mm
		500590 CCL3_MOUSE (1-92): 6.45e-34: 113: 74.19		CCR1_MOUSE (1-355): 3.7e-83: 258: 58.03
+	Hs
		561732 CL3L1_HUMAN (1-92): 2.12e-35: 117: 94.62		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		526564 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		849619 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		783833 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CCR2_HUMAN (4-326): 8.26e-78: 245: 49.69
+	Hs
		486238 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CCR4_HUMAN (9-355): 3.59e-75: 237: 44.41
+	Hs
		486239 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		561733 CL3L1_HUMAN (1-92): 2.12e-35: 117: 94.62		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		526565 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		849654 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		134354 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		134356 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		134400 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		486231 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CXCR5_HUMAN (5-318): 3.6e-41: 149: 30.34
+	Hs
		830629 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CXCR3_HUMAN (36-312): 4.4e-42: 152: 35.36
+	Hs
		526561 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CXCR5_HUMAN (5-318): 3.6e-41: 149: 30.34