HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 920 Hs			1 509
+	Hs
		487535 ANDR_HUMAN (1-920): 0: 966: 100.00		SHC4_HUMAN (7-506): 3.96e-80: 263: 16.09
+	Hs
		487621 ANDR_HUMAN (1-920): 0: 966: 100.00		SHC3_HUMAN (16-507): 3.95e-75: 249: 16.82
+	Hs
		487161 ANDR_HUMAN (1-920): 0: 966: 100.00		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		487088 ANDR_HUMAN (1-920): 0: 966: 100.00		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		442764 ANDR_HUMAN (1-920): 0: 966: 100.00		HCK_HUMAN (261-507): 1.14e-54: 193: 15.75
+	Hs
		454790 ANDR_HUMAN (1-920): 0: 966: 100.00		FGR_HUMAN (280-509): 1.78e-54: 193: 16.80
+	Hs
		433225 ANDR_HUMAN (1-920): 0: 966: 100.00		YES_HUMAN (252-488): 8.79e-54: 191: 17.21
+	Hs
		487512 ANDR_HUMAN (1-920): 0: 966: 100.00		SHE_HUMAN (51-508): 1.23e-53: 190: 27.77
+	Hs
		487310 ANDR_HUMAN (1-920): 0: 966: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		487203 ANDR_HUMAN (1-920): 0: 966: 100.00		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Hs
		337320 ANDR_HUMAN (1-920): 0: 966: 100.00		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Hs
		275164 ANDR_HUMAN (1-920): 0: 966: 100.00		GRAP2_HUMAN (354-490): 4.56e-18: 87.3: 24.64
+	Hs
		369042 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		368894 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Rn
		411266 ESR1_RAT (378-904): 2.19e-130: 406: 20.94		SRC_RAT (264-488): 6e-63: 216: 17.30
+	Mm
		403414 ESR1_MOUSE (378-904): 2.5e-129: 403: 21.30		SRC_MOUSE (264-488): 1.12e-63: 218: 18.64
+	Hs
		368834 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		YES_HUMAN (252-488): 8.79e-54: 191: 17.21
+	Hs
		377057 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		522762 RXRA_HUMAN (392-902): 7.05e-120: 374: 19.84		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		377007 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32