HitPredict

Interactor 1: RRAS (P10301)
Ras-related protein R-Ras (EC 3.6.5.-) (p23)
Gene: RRAS

Interactor 2: GNDS (Q12967)
Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF)
Gene: RALGDS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	7809086
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 218 Hs			1 914
+	Hs
		905420 RRAS2_HUMAN (42-218): 1.8e-88: 260: 66.85		GNDS_HUMAN (1-914): 0: 882: 100.00
+	Hs
		156094 RASM_HUMAN (21-199): 4.28e-56: 179: 56.11		GNDS_HUMAN (1-914): 0: 882: 100.00
+	Hs
		349279 RASH_HUMAN (42-217): 1.68e-56: 179: 53.41		GNDS_HUMAN (1-914): 0: 882: 100.00
+	Mm
		976137 RASH_MOUSE (42-217): 1.68e-56: 179: 53.41		GNDS_MOUSE (61-914): 0: 804: 85.13
+	Dm
		381636 RAS2_DROME (28-199): 1.88e-76: 229: 68.61		Q9U4U5_DROME (65-887): 4.47e-166: 511: 27.40
+	Dm
		442968 RAP1_DROME (30-190): 1.55e-56: 179: 53.42		Q9GR11_DROME (65-887): 7.88e-171: 517: 27.52
+	Dm
		442959 RAP1_DROME (30-190): 1.55e-56: 179: 53.42		Q86BI2_DROME (65-887): 5.66e-170: 515: 27.40
+	Dm
		442969 RAP1_DROME (30-190): 1.55e-56: 179: 53.42		Q9U4U5_DROME (65-887): 4.47e-166: 511: 27.40
+	Hs
		156101 RASM_HUMAN (21-199): 4.28e-56: 179: 56.11		RPGF5_HUMAN (53-648): 2.74e-121: 382: 16.18
+	Ce
		1089983 RAP1_CAEEL (28-218): 8.25e-78: 233: 47.12		Q19770_CAEEL (237-817): 2.5e-92: 307: 12.11
+	Hs
		156099 RASM_HUMAN (21-199): 4.28e-56: 179: 56.11		RPGF6_HUMAN (322-772): 3.38e-80: 286: 15.86
+	Hs
		905457 RRAS2_HUMAN (42-218): 1.8e-88: 260: 66.85		RGL1_HUMAN (58-252): 1.13e-47: 184: 46.00
+	Hs
		349311 RASH_HUMAN (42-217): 1.68e-56: 179: 53.41		RPGF1_HUMAN (370-660): 1.16e-67: 247: 26.71
+	Dm
		442976 RAP1_DROME (30-190): 1.55e-56: 179: 53.42		Q9VMF3_DROME (359-614): 2.99e-64: 238: 22.66
+	Hs
		905428 RRAS2_HUMAN (42-218): 1.8e-88: 260: 66.85		RGL3_HUMAN (62-248): 1.8e-34: 143: 26.84
+	Hs
		171534 RRAS_HUMAN (1-218): 1.49e-97: 284: 100.00		RGL2_HUMAN (62-253): 1.03e-18: 93.5: 20.20
+	Hs
		171543 RRAS2_HUMAN (42-218): 1.8e-88: 260: 66.85		RGL2_HUMAN (62-253): 1.03e-18: 93.5: 20.20
+	Mm
		1113379 RASH_MOUSE (42-217): 1.68e-56: 179: 53.41		RGL3_MOUSE (62-276): 4.63e-40: 160: 26.27
+	Hs
		349267 RASH_HUMAN (42-217): 1.68e-56: 179: 53.41		SOS1_HUMAN (16-336): 1.15e-38: 158: 14.01
+	Hs
		171532 RASH_HUMAN (42-217): 1.68e-56: 179: 53.41		RGL2_HUMAN (62-253): 1.03e-18: 93.5: 20.20