Protein: SCAFB
Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129)

Gene: SCAFB, SCAF11
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q99590

Gene Ontology (top 5):
GO:0000245 - spliceosomal complex assembly
GO:0000375 - RNA splicing, via transesterification reactions
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

685699

U2AF2
Splicing factor U2AF 65 kDa subunit

5

4

Small-scale

0.723

High

1405512

LC7L2
Putative RNA-binding protein Luc7-like 2

4

3

High-throughput

0.691

High

1405501

ANM8
Protein arginine N-methyltransferase 8

4

3

High-throughput

0.630

High

1028699

U2AF1
Splicing factor U2AF 35 kDa subunit

2

1

High-throughput

0.628

High

1239653

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

3

High-throughput

0.628

High

1061113

SRSF1
Serine/arginine-rich splicing factor 1

2

19

Small-scale

0.614

High

130593

SPT5H
Transcription elongation factor SPT5

2

6

High-throughput

0.611

High

1006652

SRPK2
SRSF protein kinase 2

2

19

High-throughput

0.601

High

468725

HS90B
Heat shock protein HSP 90-beta

2

5

High-throughput

0.584

High

355099

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

2

5

High-throughput

0.574

High

1352891

TP4AP
Short transient receptor potential channel 4-associated protein

2

1

High-throughput

0.574

High

396785

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

473008

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.536

High

478177

SNRPA
U1 small nuclear ribonucleoprotein A

1

5

High-throughput

0.536

High

480283

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

542178

TOP1
DNA topoisomerase 1

1

4

High-throughput

0.536

High

574440

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.536

High

601827

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

High-throughput

0.536

High

854251

KI67
Proliferation marker protein Ki-67

1

11

High-throughput

0.536

High

879748

MAPK2
MAP kinase-activated protein kinase 2

1

1

High-throughput

0.536

High

912220

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

2

High-throughput

0.536

High

937870

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.536

High

966790

1433G
14-3-3 protein gamma

1

4

High-throughput

0.536

High

990651

1433Z
14-3-3 protein zeta/delta

1

4

High-throughput

0.536

High

1013100

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

1

High-throughput

0.536

High

1065388

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

1099214

SRSF5
Serine/arginine-rich splicing factor 5

1

18

High-throughput

0.536

High

1099494

SRSF6
Serine/arginine-rich splicing factor 6

1

18

High-throughput

0.536

High

1115018

CUL4A
Cullin-4A

1

11

High-throughput

0.536

High

1160263

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

8

High-throughput

0.536

High

1163163

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1340649

NEDD1
Protein NEDD1

1

9

High-throughput

0.536

High

1368794

EZH1
Histone-lysine N-methyltransferase EZH1

1

6

High-throughput

0.536

High

1405489

GCP2
Gamma-tubulin complex component 2

1

4

High-throughput

0.536

High

1405506

ZNFX1
NFX1-type zinc finger-containing protein 1

1

1

High-throughput

0.536

High

1405511

SRPK3
SRSF protein kinase 3

1

19

High-throughput

0.536

High

1405514

TNPO3
Transportin-3

1

3

High-throughput

0.536

High

283133

PSIP1
PC4 and SFRS1-interacting protein

1

3

High-throughput

0.515

High

261969

RNH1
Ribonuclease H1

1

0

High-throughput

0.513

High

477842

RM03
Large ribosomal subunit protein uL3m

1

0

High-throughput

0.513

High

809803

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.513

High

948578

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

971924

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

974026

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

1242574

MZT2A
Mitotic-spindle organizing protein 2A

1

0

High-throughput

0.513

High

1294349

ZN677
Zinc finger protein 677

1

0

High-throughput

0.513

High

1405513

NDK7
Nucleoside diphosphate kinase homolog 7

1

0

High-throughput

0.513

High

964432

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

277397

TP4A3
Protein tyrosine phosphatase type IVA 3

1

5

High-throughput

0.489

High

354032

CX001
Putative transmembrane protein CXorf1

1

1

High-throughput

0.489

High

552362

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.489

High

655902

TBG1
Tubulin gamma-1 chain

1

2

High-throughput

0.489

High

692788

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.489

High

1063850

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.489

High

1065856

MZT1
Mitotic-spindle organizing protein 1

1

1

High-throughput

0.489

High

1386774

GCP3
Gamma-tubulin complex component 3

1

4

High-throughput

0.489

High

1401967

GCP6
Gamma-tubulin complex component 6

1

4

High-throughput

0.489

High

1401987

GCP5
Gamma-tubulin complex component 5

1

4

High-throughput

0.489

High

1405508

GCP4
Gamma-tubulin complex component 4

1

4

High-throughput

0.489

High

505604

ATX1L
Ataxin-1-like

1

4

High-throughput

0.481

High

1016582

SRSF3
Serine/arginine-rich splicing factor 3

1

20

Small-scale

0.481

High

129361

MEN1
Menin

1

3

High-throughput

0.479

High

157771

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

372943

MYC
Myc proto-oncogene protein

1

14

High-throughput

0.479

High

401355

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

406550

MYCN
N-myc proto-oncogene protein

1

14

High-throughput

0.479

High

474235

NFIC
Nuclear factor 1 C-type

1

10

High-throughput

0.479

High

485362

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

9

High-throughput

0.479

High

487671

PARP1
Poly [ADP-ribose] polymerase 1

1

9

High-throughput

0.479

High

521885

H14
Histone H1.4

1

12

High-throughput

0.479

High

558355

XRCC6
X-ray repair cross-complementing protein 6

1

6

High-throughput

0.479

High

587780

DESP
Desmoplakin

1

9

High-throughput

0.479

High

621725

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

697232

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

765824

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.479

High

898781

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.479

High

980199

H4
Histone H4

1

7

High-throughput

0.479

High

981041

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

998724

H31
Histone H3.1

1

10

High-throughput

0.479

High

1017153

H33
Histone H3.3

1

10

High-throughput

0.479

High

1033760

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

1045684

TF65
Transcription factor p65

1

6

High-throughput

0.479

High

1088523

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

6

High-throughput

0.479

High

1128096

DHX8
ATP-dependent RNA helicase DHX8

1

9

High-throughput

0.479

High

1132920

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

6

High-throughput

0.479

High

1137479

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1138543

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1250644

BCOR
BCL-6 corepressor

1

12

High-throughput

0.479

High

1270402

SND1
Staphylococcal nuclease domain-containing protein 1

1

1

Small-scale

0.479

High

1271209

DPPA4
Developmental pluripotency-associated protein 4

1

3

High-throughput

0.479

High

1276694

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1313367

SMC5
Structural maintenance of chromosomes protein 5

1

10

High-throughput

0.479

High

1352708

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1367103

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1368868

RBP56
TATA-binding protein-associated factor 2N

1

7

High-throughput

0.479

High

1380112

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

1387517

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

13

High-throughput

0.479

High

1405487

BARD1
BRCA1-associated RING domain protein 1

1

10

High-throughput

0.479

High

1405488

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1405490

DDX23
Probable ATP-dependent RNA helicase DDX23

1

6

High-throughput

0.479

High

1405493

KLF16
Krueppel-like factor 16

1

7

High-throughput

0.479

High

1405497

NANOG
Homeobox protein NANOG

1

11

High-throughput

0.479

High

1405500

ANLN
Anillin

1

7

High-throughput

0.479

High

1405502

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

1405503

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.479

High

1405504

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1405507

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1192168

LEGL
Galectin-related protein

1

1

High-throughput

0.470

High

827904

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.460

High

770268

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.458

High

1039354

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.458

High

1405491

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1405515

EID1
EP300-interacting inhibitor of differentiation 1

1

0

Small-scale

0.458

High

445053

S10A9
Protein S100-A9

1

1

Small-scale

0.457

High

290692

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.445

High

686367

RL13
Large ribosomal subunit protein eL13

1

3

High-throughput

0.445

High

1337411

SRFB1
Serum response factor-binding protein 1

1

2

High-throughput

0.445

High

1405498

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.445

High

1405499

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

8

High-throughput

0.445

High

1405510

ABT1
Activator of basal transcription 1

1

3

High-throughput

0.445

High

375869

RASK
GTPase KRas

1

6

High-throughput

0.437

High

419157

H2A1B
Histone H2A type 1-B/E

1

8

High-throughput

0.437

High

1211649

FBP1L
Formin-binding protein 1-like

1

3

High-throughput

0.437

High

1385837

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.437

High

1405492

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.437

High

1405494

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1405509

HECD1
E3 ubiquitin-protein ligase HECTD1

1

9

High-throughput

0.437

High

1405496

GHC1
Mitochondrial glutamate carrier 1

1

2

High-throughput

0.407

High

169206

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

488077

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

652669

GNLY
Granulysin

1

0

High-throughput

0.279

Low

1339508

FDSCP
Follicular dendritic cell secreted peptide

1

0

High-throughput

0.279

Low

1384720

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1405495

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.279

Low

1405505

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

907834

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025