HitPredict

Interactor 1: UCHL1 (P09936)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
Gene: UCHL1

Interactor 2: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.800

Property	Details
Experiments	37739965, 16169070
Identification Methods	affinity chromatography technology, pull down, two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Peptidase_C12~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding and 1 others more... GO:0043025 - neuronal cell body
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 223 Hs			1 229
+	Hs
		488380 UCHL1_HUMAN (1-223): 2.39e-103: 299: 100.00		UBC_HUMAN (1-228): 7.54e-92: 285: 100.00
+	Hs
		507066 UCHL3_HUMAN (2-222): 3.84e-101: 294: 54.43		UBB_HUMAN (1-229): 2.65e-99: 289: 100.00
+	Hs
		583873 UCHL3_HUMAN (2-222): 3.84e-101: 294: 54.43		Q5U5U6_HUMAN (1-229): 2.65e-99: 289: 100.00
+	Hs
		507494 UCHL3_HUMAN (2-222): 3.84e-101: 294: 54.43		UBC_HUMAN (1-228): 7.54e-92: 285: 100.00
+	Hs
		508905 UCHL5_HUMAN (2-220): 6.64e-99: 292: 21.68		UBC_HUMAN (1-228): 7.54e-92: 285: 100.00
+	Hs
		508361 BAP1_HUMAN (3-220): 6.72e-78: 249: 22.27		UBC_HUMAN (1-228): 7.54e-92: 285: 100.00
+	Rn
		1028149 UCHL1_RAT (1-223): 4.07e-102: 296: 95.52		UBC_RAT (1-181): 3.75e-62: 209: 96.13
+	Mm
		509316 UCHL1_MOUSE (1-223): 4.07e-102: 296: 95.52		UBC_MOUSE (1-181): 8.42e-63: 209: 96.13
+	Mm
		509299 UCHL3_MOUSE (2-222): 2.67e-101: 294: 55.31		UBC_MOUSE (1-181): 8.42e-63: 209: 96.13
+	Mm
		509325 UCHL5_MOUSE (2-220): 2.43e-99: 293: 22.12		UBC_MOUSE (1-181): 8.42e-63: 209: 96.13
+	Mm
		508999 UCHL4_MOUSE (2-222): 1.92e-97: 284: 53.71		UBC_MOUSE (1-181): 8.42e-63: 209: 96.13
+	Sc
		509486 UBL1_YEAST (5-219): 6.44e-54: 174: 26.29		UBI4P_YEAST (1-228): 3.4e-91: 274: 96.05
+	Hs
		488443 UCHL1_HUMAN (1-223): 2.39e-103: 299: 100.00		RS27A_HUMAN (153-228): 1.77e-44: 147: 100.00
+	Hs
		987140 BAP1_HUMAN (3-220): 6.72e-78: 249: 22.27		RS27A_HUMAN (153-228): 1.77e-44: 147: 100.00