HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: DDX5 (P17844)
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)
Gene: DDX5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26269332, 35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016607 - nuclear speck and 1 others more... GO:0019899 - enzyme binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 614
+	Mm
		498084 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q8BTS0_MOUSE (1-614): 0: 617: 97.89
+	Hs
		497386 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Mm
		498030 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DDX17_MOUSE (30-612): 0: 536: 66.67
+	Hs
		497260 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX42_HUMAN (16-603): 3.74e-156: 474: 34.09
+	Hs
		133854 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52
+	Mm
		498056 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DDX3Y_MOUSE (2-556): 1.98e-143: 432: 35.07
+	Hs
		497225 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX46_HUMAN (50-477): 3.83e-108: 350: 40.68
+	Dm
		1370335 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VXW2_DROME (54-474): 1.99e-110: 360: 43.65