HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26269332, 35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030424 - axon and 1 others more... GO:0030425 - dendrite
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 4684
+	Hs
		503287 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		PLEC_HUMAN (1-4684): 0: 1783: 100.00
+	Hs
		496188 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTN1_HUMAN (153-876): 1.96e-112: 384: 23.94
+	Hs
		503257 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		ACTN1_HUMAN (153-876): 1.96e-112: 384: 23.94
+	Hs
		164558 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN2_HUMAN (1390-3166): 2.85e-25: 118: 12.24
+	Hs
		496865 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53
+	Hs
		497586 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN4_HUMAN (1394-3173): 6.68e-13: 78.1: 10.95
+	Rn
		582039 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SPTN2_RAT (1390-3173): 3.99e-23: 112: 11.92
+	Rn
		94264 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SPTN2_RAT (1390-3173): 3.99e-23: 112: 11.92
+	Hs
		496228 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DESP_HUMAN (351-874): 8.53e-10: 68.1: 8.21
+	Dm
		54271 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		A1Z9I8_DROME (337-2581): 1.27e-34: 150: 10.41