HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 126
+	Hs
		420796 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		497505 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		H2B1M_HUMAN (1-126): 5.38e-54: 166: 96.03
+	Hs
		241431 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		497292 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Rn
		581988 TAU_RAT (1-758): 4.86e-75: 260: 71.47		H2B1_RAT (1-126): 7.04e-51: 159: 96.03
+	Rn
		94210 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		H2B1_RAT (1-126): 7.04e-51: 159: 96.03
+	Hs
		653955 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		241456 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		653945 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		654046 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62
+	Hs
		1056847 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1056919 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		918364 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707631 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		152598 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1087210 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918462 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707663 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1170067 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		1170078 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04