HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: RTN4 (Q9NQC3)
Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)
Gene: RTN4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005886 - plasma membrane GO:0043005 - neuron projection
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1192
+	Hs
		306971 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RTN3_HUMAN (269-1191): 7.4e-55: 210: 22.06
+	Hs
		497115 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RTN1_HUMAN (419-1192): 1e-50: 194: 23.36
+	Dm
		54339 A1Z9J3_DROME (14-746): 5.58e-33: 139: 11.47		Q9VMV9_DROME (731-1192): 5.95e-64: 230: 25.43
+	Hs
		554259 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		MUC1_HUMAN (24-1001): 1.42e-40: 165: 9.23
+	Dm
		113976 M9PB30_DROME (69-755): 2.38e-24: 112: 8.39		M9PB30_DROME (9-335): 1.96e-11: 71.3: 14.33
+	Mm
		1351630 PCLO_MOUSE (6-742): 3.27e-11: 69.3: 9.66		PCLO_MOUSE (6-1011): 1.82e-10: 67.9: 12.03