HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: UBQL4 (Q9NRR5)
Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75)
Gene: UBQLN4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	35063084, 26269332
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006974 - DNA damage response
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 601
+	Hs
		497794 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		UBQL1_HUMAN (11-601): 1.16e-127: 389: 59.16
+	Hs
		497747 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		UBQL2_HUMAN (9-601): 6.99e-118: 365: 51.59
+	Hs
		496518 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		BAG6_HUMAN (2-547): 7.28e-64: 229: 13.41
+	Hs
		1057015 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		UBQL2_HUMAN (9-601): 6.99e-118: 365: 51.59
+	Hs
		496639 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RD23A_HUMAN (13-318): 1.95e-47: 172: 16.37
+	Hs
		496640 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RD23B_HUMAN (13-275): 2e-37: 145: 18.29
+	Hs
		496787 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RL40_HUMAN (13-103): 6.24e-34: 127: 28.26
+	Hs
		496786 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RS27A_HUMAN (13-99): 1.11e-12: 68.1: 29.55
+	Mm
		497988 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		RS27A_MOUSE (13-99): 1.13e-12: 68.1: 29.55
+	At
		1092118 Q9LIE8_ARATH (385-755): 6.46e-13: 74.7: 11.20		UBQ3_ARATH (9-88): 1.35e-32: 129: 30.86