HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.819

Property	Details
Experiments	9355737, 10358045
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0042127 - regulation of cell population proliferation GO:0042803 - protein homodimerization activity
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 750
+	Hs
		499250 KIT_HUMAN (1-976): 0: 807: 100.00		STA5B_HUMAN (1-749): 0: 787: 28.82
+	Hs
		499239 KIT_HUMAN (1-976): 0: 807: 100.00		STA5A_HUMAN (1-748): 0: 780: 28.14
+	Hs
		452369 PGFRB_HUMAN (30-954): 0: 591: 30.62		STA5A_HUMAN (1-748): 0: 780: 28.14
+	Hs
		601474 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		STAT3_HUMAN (1-740): 0: 864: 52.61
+	Hs
		572594 VGFR1_HUMAN (3-112): 1.99e-14: 80.2: 13.01		STAT1_HUMAN (1-750): 0: 988: 100.00
+	Hs
		729622 VGFR2_HUMAN (3-106): 1.62e-13: 77.5: 14.04		STAT1_HUMAN (1-750): 0: 988: 100.00
+	Hs
		609197 FGFR3_HUMAN (3-331): 4.6e-51: 195: 13.39		STAT3_HUMAN (1-740): 0: 864: 52.61
+	Hs
		601481 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		STA5B_HUMAN (1-749): 0: 787: 28.82
+	Hs
		601477 FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10		STA5A_HUMAN (1-748): 0: 780: 28.14
+	Hs
		507894 FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25		STAT3_HUMAN (1-740): 0: 864: 52.61
+	Hs
		572592 VGFR1_HUMAN (3-112): 1.99e-14: 80.2: 13.01		STAT3_HUMAN (1-740): 0: 864: 52.61
+	Mm
		729405 VGFR3_MOUSE (3-111): 1.31e-13: 77.5: 15.57		STAT3_MOUSE (1-740): 0: 865: 52.61
+	Hs
		729621 VGFR2_HUMAN (3-106): 1.62e-13: 77.5: 14.04		STAT3_HUMAN (1-740): 0: 864: 52.61