HitPredict

Interactor 1: CH60 (P10809)
60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein)
Gene: HSPD1

Interactor 2: CH10 (P61604)
10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1)
Gene: HSPE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

The method score is based on:

Property	Details
Experiments	29568061, 10205158, 12387818, 14717702
Identification Methods	proximity labelling technology, affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	Cpn10~Cpn60_TCP1
Common GO terms	GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006457 - protein folding and 6 others more... GO:0006919 - activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006986 - response to unfolded protein GO:0016020 - membrane GO:0051082 - unfolded protein binding GO:0051087 - protein-folding chaperone binding GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	573
Hs

1	102

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024