Protein: ILV3
Dihydroxy-acid dehydratase, mitochondrial (DAD) (EC 4.2.1.9)

Gene: ILV3
Organism: Saccharomyces cerevisiae S288C
Interactions: 104
UniProt ID: P39522

Gene Ontology (top 5):
GO:0004160 - dihydroxy-acid dehydratase activity
GO:0005739 - mitochondrion
GO:0009082 - branched-chain amino acid biosynthetic process
GO:0009097 - isoleucine biosynthetic process
GO:0009099 - L-valine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

812184

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

2

High-throughput

0.618

High

510500

HSP77
Import motor subunit, mitochondrial

2

1

High-throughput

0.584

High

579411

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.584

High

367029

ATPB
ATP synthase subunit beta, mitochondrial

2

1

High-throughput

0.571

High

622364

ACON
Aconitate hydratase, mitochondrial

2

1

High-throughput

0.571

High

781378

MIC60
MICOS complex subunit MIC60

2

0

High-throughput

0.559

High

806897

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

2

0

Small-scale

0.559

High

626745

HSP60
Heat shock protein 60, mitochondrial

2

0

High-throughput

0.547

High

392747

HSP82
ATP-dependent molecular chaperone HSP82

2

1

High-throughput

0.521

High

812201

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

812216

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.479

High

452662

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

1

High-throughput

0.479

High

554927

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.479

High

596815

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

1

2

High-throughput

0.479

High

619357

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.479

High

635961

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

752270

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

785925

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

812202

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

361483

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.458

High

439135

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

448537

RHO1
GTP-binding protein RHO1

1

0

High-throughput

0.458

High

456399

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.458

High

484761

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

594946

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

604948

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

641096

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.458

High

654602

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

661793

TOM40
Mitochondrial import receptor subunit TOM40

1

0

High-throughput

0.458

High

673503

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.458

High

677805

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.458

High

679693

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

685102

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

0

High-throughput

0.458

High

694470

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.458

High

697330

COQ8
Atypical kinase COQ8, mitochondrial

1

0

High-throughput

0.458

High

701526

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

0

High-throughput

0.458

High

737458

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.458

High

746256

NFU1
NifU-like protein, mitochondrial

1

0

Small-scale

0.458

High

746840

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

746992

PREP
Presequence protease, mitochondrial

1

0

High-throughput

0.458

High

757966

PRX1
Peroxiredoxin PRX1, mitochondrial

1

0

High-throughput

0.458

High

782162

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

800343

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.458

High

804796

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

812186

BOL3
BolA-like protein 3

1

0

Small-scale

0.458

High

812189

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

0

High-throughput

0.458

High

812191

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

812192

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

812194

ETFB
Probable electron transfer flavoprotein subunit beta

1

0

High-throughput

0.458

High

812195

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.458

High

812198

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

812200

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

812203

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.458

High

812205

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

812209

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

812215

ETFA
Probable electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

526722

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

812187

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.445

High

727035

HS104
Heat shock protein 104

1

1

Small-scale

0.437

High

812208

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

812213

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

812214

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

359233

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

0

High-throughput

0.426

High

386714

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

394574

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

453606

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

486182

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

599023

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.426

High

644926

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.426

High

755099

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.426

High

779409

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.426

High

358219

ADH1
Alcohol dehydrogenase 1

1

1

High-throughput

0.407

High

523983

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.407

High

592264

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

740163

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.407

High

803544

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.407

High

807221

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.279

Low

558727

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

670721

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

707129

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

734986

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

748396

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

792055

GBLP
Small ribosomal subunit protein RACK1

1

0

Small-scale

0.249

Low

812030

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.249

Low

812185

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

812196

ATG18
Autophagy-related protein 18

1

0

Small-scale

0.249

Low

812199

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.249

Low

812207

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

812210

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

812211

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

812212

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

365054

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.232

Low

575455

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

684730

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.232

Low

734104

EF2
Elongation factor 2

1

0

High-throughput

0.232

Low

806711

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.232

Low

810942

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.232

Low

812188

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.232

Low

812190

IMB4
Importin subunit beta-4

1

0

High-throughput

0.232

Low

812193

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

812197

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

812204

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.232

Low

812206

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025