Protein: ACON
Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)

Gene: ACON, ACO1
Organism: Saccharomyces cerevisiae S288C
Interactions: 132
UniProt ID: P19414

Gene Ontology (top 5):
GO:0003690 - double-stranded DNA binding
GO:0003697 - single-stranded DNA binding
GO:0003729 - mRNA binding
GO:0003994 - aconitate hydratase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

622313

ACON
Aconitate hydratase, mitochondrial

2

8

Small-scale

0.783

High

510175

HSP77
Import motor subunit, mitochondrial

4

11

Small-scale

0.676

High

523008

HSP71
Heat shock protein SSA1

3

10

Small-scale

0.660

High

543764

SSB1
Ribosome-associated molecular chaperone SSB1

3

11

Small-scale

0.656

High

604895

MDHM
Malate dehydrogenase, mitochondrial

3

4

Small-scale

0.640

High

525881

HSP72
Heat shock protein SSA2

3

10

Small-scale

0.633

High

622349

HSP78
Heat shock protein 78, mitochondrial

3

4

High-throughput

0.633

High

394024

EFTU
Elongation factor Tu, mitochondrial

2

2

High-throughput

0.584

High

452809

ATPA
ATP synthase subunit alpha, mitochondrial

2

7

High-throughput

0.584

High

622342

NFU1
NifU-like protein, mitochondrial

2

4

Small-scale

0.584

High

622376

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

2

3

High-throughput

0.584

High

622387

ABF2
ARS-binding factor 2, mitochondrial

2

2

Small-scale

0.584

High

452627

ADH3
Alcohol dehydrogenase 3, mitochondrial

2

2

High-throughput

0.571

High

622364

ILV3
Dihydroxy-acid dehydratase, mitochondrial

2

1

High-throughput

0.571

High

622402

HSP42
Heat shock protein 42

2

1

High-throughput

0.537

High

622319

RFA1
Replication factor A protein 1

1

1

High-throughput

0.536

High

622406

YPT6
GTP-binding protein YPT6

1

2

High-throughput

0.536

High

622358

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

Small-scale

0.529

High

622347

UFD4
Ubiquitin fusion degradation protein 4

1

3

High-throughput

0.515

High

449314

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

0

High-throughput

0.513

High

531238

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.513

High

622332

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

622336

APE2
Aminopeptidase 2, mitochondrial

1

0

High-throughput

0.513

High

622354

ATR
Serine/threonine-protein kinase MEC1

1

0

High-throughput

0.513

High

622366

FHP
Flavohemoprotein

1

0

High-throughput

0.513

High

622371

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.513

High

622373

PSMD9
Probable 26S proteasome regulatory subunit p27

1

0

High-throughput

0.513

High

622398

DNLI4
DNA ligase 4

1

0

High-throughput

0.513

High

622316

FKBP
FK506-binding protein 1

1

4

High-throughput

0.500

High

622351

VPS21
Vacuolar protein sorting-associated protein 21

1

1

High-throughput

0.500

High

622362

PEX7
Peroxisomal targeting signal 2 receptor

1

5

High-throughput

0.500

High

622389

IMA1
Importin subunit alpha

1

1

High-throughput

0.500

High

622338

MYO4
Myosin-4

1

0

High-throughput

0.493

High

622372

RAD26
DNA repair and recombination protein RAD26

1

1

High-throughput

0.489

High

622393

ERB1
Ribosome biogenesis protein ERB1

1

1

High-throughput

0.489

High

622322

RV161
Reduced viability upon starvation protein 161

1

0

High-throughput

0.479

High

622348

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.479

High

358962

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

Small-scale

0.479

High

359145

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

Small-scale

0.479

High

360866

COX6
Cytochrome c oxidase subunit 6, mitochondrial

1

1

High-throughput

0.479

High

366920

ATPB
ATP synthase subunit beta, mitochondrial

1

7

High-throughput

0.479

High

392198

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

394220

EF1A
Elongation factor 1-alpha

1

2

Small-scale

0.479

High

439083

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

1

High-throughput

0.479

High

441693

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

453245

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

3

High-throughput

0.479

High

454635

PUT2
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

5

High-throughput

0.479

High

456326

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.479

High

469975

FUMH
Fumarate hydratase, mitochondrial

1

3

High-throughput

0.479

High

502838

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

554878

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.479

High

578814

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

594874

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

5

High-throughput

0.479

High

622315

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.479

High

622318

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

3

High-throughput

0.479

High

622321

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

622325

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

622326

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

2

High-throughput

0.479

High

622328

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

622330

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

5

High-throughput

0.479

High

622333

HS104
Heat shock protein 104

1

4

High-throughput

0.479

High

622337

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

High-throughput

0.479

High

622339

ZUO1
Zuotin

1

3

Small-scale

0.479

High

622340

HSP7F
Heat shock protein homolog SSE1

1

15

Small-scale

0.479

High

622344

PREP
Presequence protease, mitochondrial

1

3

High-throughput

0.479

High

622350

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.479

High

622353

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

622363

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

622367

BOL3
BolA-like protein 3

1

2

Small-scale

0.479

High

622368

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

3

High-throughput

0.479

High

622370

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

Small-scale

0.479

High

622375

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

622385

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

622386

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

1

High-throughput

0.479

High

622395

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

1

High-throughput

0.479

High

622382

MLC1
Myosin light chain 1

1

1

High-throughput

0.470

High

382825

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

444827

SIR3
Regulatory protein SIR3

1

0

High-throughput

0.458

High

454699

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.458

High

513625

RL2A
Large ribosomal subunit protein uL2A

1

0

Small-scale

0.458

High

622320

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

622323

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.458

High

622324

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.458

High

622327

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

0

High-throughput

0.458

High

622329

COQ8
Atypical kinase COQ8, mitochondrial

1

0

High-throughput

0.458

High

622334

MSS51
Protein MSS51, mitochondrial

1

0

Small-scale

0.458

High

622335

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

622341

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

622343

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

622345

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

622352

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

622356

FMP23
Protein FMP23, mitochondrial

1

0

High-throughput

0.458

High

622357

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

622365

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

622369

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

622374

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

622380

RL4B
Large ribosomal subunit protein uL4B

1

0

Small-scale

0.458

High

622383

MNP1
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.458

High

622388

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

622390

YP107
UPF0651 protein YPL107W, mitochondrial

1

0

High-throughput

0.458

High

622391

ISU1
Iron sulfur cluster assembly protein 1, mitochondrial

1

0

High-throughput

0.458

High

622396

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

622400

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

622401

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

622404

FMP16
Protein FMP16, mitochondrial

1

0

High-throughput

0.458

High

622405

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

622381

SEH1
Nucleoporin SEH1

1

2

High-throughput

0.457

High

481474

HSP73
Heat shock protein SSA3

1

10

High-throughput

0.445

High

358110

ADH1
Alcohol dehydrogenase 1

1

2

Small-scale

0.437

High

574633

KSS1
Mitogen-activated protein kinase KSS1

1

1

High-throughput

0.437

High

622331

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

622359

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

1

Small-scale

0.437

High

622397

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

622399

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

622403

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

622361

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.407

High

415196

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.279

Low

622378

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.279

Low

622392

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.279

Low

622394

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

449061

CALM
Calmodulin

1

0

High-throughput

0.269

Low

459013

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

622314

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.261

Low

622360

TEM1
Protein TEM1

1

0

High-throughput

0.261

Low

364921

KPYK1
Pyruvate kinase 1

1

0

Small-scale

0.249

Low

622317

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.249

Low

622346

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

622355

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

622377

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.232

Low

622379

SEC16
COPII coat assembly protein SEC16

1

0

High-throughput

0.232

Low

622384

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025