HitPredict

Interactor 1: THA (P10827)
Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)
Gene: THRA

Interactor 2: MED17 (Q9NVC6)
Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)
Gene: MED17

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	8710870, 14576168
Identification Methods	biochemical, pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 651
+	Hs
		370538 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		MED17_HUMAN (1-651): 0: 1032: 100.00
+	Hs
		782672 HNF4A_HUMAN (8-451): 1.23e-104: 322: 21.87		MED17_HUMAN (1-651): 0: 1032: 100.00
+	Mm
		1142698 ERR2_MOUSE (1-409): 3.66e-101: 312: 21.41		MED17_MOUSE (1-651): 0: 1033: 95.70
+	Hs
		1061333 NR1I3_HUMAN (48-376): 7.96e-40: 149: 32.16		MED17_HUMAN (1-651): 0: 1032: 100.00