HitPredict

Interactor 1: ACT1 (P10987)
Actin-5C (EC 3.6.4.-)
Gene: Act5C

Interactor 2: BRM (P25439)
ATP-dependent helicase brm (EC 3.6.4.12) (Homeotic gene regulator) (Protein brahma)
Gene: BRM

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	9735357, 10601025, 10809665, 27687497, 15060132
Identification Methods	affinity chromatography technology, chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~HSA, Actin~SNF2-rel_dom
Common GO terms	GO:0005524 - ATP binding GO:0006338 - chromatin remodeling GO:0006357 - regulation of transcription by RNA polymerase II GO:0035060 - brahma complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 376 Dm			1 1638
+	Dm
		361138 ACT2_DROME (1-376): 0: 604: 99.47		BRM_DROME (1-1630): 0: 1038: 100.00
+	Xl
		292752 ACTB_XENLA (3-376): 0: 603: 98.13		Q4VQ79_XENLA (134-1530): 0: 893: 53.56
+	Hs
		229358 ACTC_HUMAN (2-376): 0: 598: 94.40		SMCA5_HUMAN (621-1571): 0: 828: 28.82
+	Hs
		891769 ACTB_HUMAN (1-376): 0: 603: 97.61		CHD4_HUMAN (403-1599): 0: 783: 21.77
+	Hs
		932158 ACTC_HUMAN (2-376): 0: 598: 94.40		CHD4_HUMAN (403-1599): 0: 783: 21.77
+	Hs
		891731 ACTB_HUMAN (1-376): 0: 603: 97.61		CHD3_HUMAN (392-1632): 0: 776: 22.27
+	Hs
		929837 ACTG_HUMAN (3-376): 0: 603: 98.13		CHD3_HUMAN (392-1632): 0: 776: 22.27
+	Hs
		932125 ACTC_HUMAN (2-376): 0: 598: 94.40		CHD3_HUMAN (392-1632): 0: 776: 22.27
+	Zm
		13638 A0A1D6FW13_MAIZE (2-376): 0: 594: 89.60		A0A1D6MT91_MAIZE (667-1537): 0: 778: 31.35
+	Hs
		846794 ACTBL_HUMAN (1-376): 0: 733: 90.69		SMCA2_HUMAN (231-741): 9.52e-09: 62.8: 10.17
+	Mm
		929785 ACTG_MOUSE (3-376): 0: 603: 98.13		SMCA4_MOUSE (1-317): 9.99e-14: 79: 18.07
+	Mm
		929795 ACTG_MOUSE (3-376): 0: 603: 98.13		SMCA2_MOUSE (1-317): 1.1e-12: 75.5: 17.61
+	Hs
		846910 ACTB_HUMAN (1-376): 0: 603: 97.61		SMCA4_HUMAN (182-732): 3.64e-11: 70.5: 9.57
+	Hs
		846917 ACTG_HUMAN (3-376): 0: 603: 98.13		SMCA4_HUMAN (182-732): 3.64e-11: 70.5: 9.57
+	Hs
		846918 ACTC_HUMAN (2-376): 0: 598: 94.40		SMCA4_HUMAN (182-732): 3.64e-11: 70.5: 9.57
+	Hs
		846919 ACTS_HUMAN (2-376): 0: 598: 93.33		SMCA4_HUMAN (182-732): 3.64e-11: 70.5: 9.57
+	Hs
		846742 ACTC_HUMAN (2-376): 0: 598: 94.40		SMCA2_HUMAN (231-741): 9.52e-09: 62.8: 10.17