HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

The method score is based on:

Property	Details
Experiments	27684187, 25864199, 26496610, 36042349
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	HSP70~HSP70
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 16 others more... GO:0005925 - focal adhesion GO:0009986 - cell surface GO:0016020 - membrane GO:0016887 - ATP hydrolysis activity GO:0019899 - enzyme binding GO:0031072 - heat shock protein binding GO:0031625 - ubiquitin protein ligase binding GO:0042026 - protein refolding GO:0042470 - melanosome GO:0044183 - protein folding chaperone GO:0045296 - cadherin binding GO:0051082 - unfolded protein binding GO:0051085 - chaperone cofactor-dependent protein refolding GO:0051087 - protein-folding chaperone binding GO:0070062 - extracellular exosome GO:0140662 - ATP-dependent protein folding chaperone
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1	654
Hs

1	646

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024