Protein: YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF (EC 2.1.1.-)

Gene: YFIF
Organism: Escherichia coli K-12
Interactions: 93
UniProt ID: P0AGJ5

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005829 - cytosol
GO:0006396 - RNA processing
GO:0008173 - RNA methyltransferase activity
GO:0032259 - methylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

501615

RL2
Large ribosomal subunit protein uL2

3

4

High-throughput

0.657

High

493311

RS11
Small ribosomal subunit protein uS11

3

1

High-throughput

0.643

High

492833

RL20
Large ribosomal subunit protein bL20

2

1

High-throughput

0.588

High

493160

RL9
Large ribosomal subunit protein bL9

2

2

High-throughput

0.588

High

493335

RS12
Small ribosomal subunit protein uS12

2

1

High-throughput

0.588

High

493540

RS18
Small ribosomal subunit protein bS18

2

2

High-throughput

0.588

High

494798

SSRP
SsrA-binding protein

2

1

High-throughput

0.588

High

496262

CSPD
Cold shock-like protein CspD

2

4

High-throughput

0.588

High

499061

DBHA
DNA-binding protein HU-alpha

2

1

High-throughput

0.588

High

501598

RL18
Large ribosomal subunit protein uL18

2

3

High-throughput

0.588

High

501603

RNE
Ribonuclease E

2

1

High-throughput

0.588

High

501620

RS21
Small ribosomal subunit protein bS21

2

1

High-throughput

0.588

High

501159

RL17
Large ribosomal subunit protein bL17

2

0

High-throughput

0.585

High

501519

SSB
Single-stranded DNA-binding protein

2

2

High-throughput

0.571

High

491500

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

2

0

High-throughput

0.563

High

493395

RS13
Small ribosomal subunit protein uS13

2

0

High-throughput

0.563

High

493575

RS19
Small ribosomal subunit protein uS19

2

0

High-throughput

0.563

High

493631

RS20
Small ribosomal subunit protein bS20

2

0

High-throughput

0.563

High

494379

RS8
Small ribosomal subunit protein uS8

2

0

High-throughput

0.563

High

494572

RNPA
Ribonuclease P protein component

2

0

High-throughput

0.563

High

499732

YIBL
Uncharacterized protein YibL

2

0

High-throughput

0.563

High

499970

RS15
Small ribosomal subunit protein uS15

2

0

High-throughput

0.563

High

501597

YHBY
RNA-binding protein YhbY

2

0

High-throughput

0.563

High

501604

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

2

0

High-throughput

0.563

High

501613

HRPA
ATP-dependent RNA helicase HrpA

2

0

High-throughput

0.563

High

501627

SUFC
Probable ATP-dependent transporter SufC

2

0

High-throughput

0.563

High

495363

UVRC
UvrABC system protein C

2

1

High-throughput

0.549

High

494105

RS4
Small ribosomal subunit protein uS4

2

0

High-throughput

0.545

High

493489

RS16
Small ribosomal subunit protein bS16

2

1

High-throughput

0.537

High

501606

HOLB
DNA polymerase III subunit delta'

2

1

High-throughput

0.537

High

490931

IHFA
Integration host factor subunit alpha

1

1

High-throughput

0.536

High

501607

GREB
Transcription elongation factor GreB

1

1

High-throughput

0.489

High

382699

RS7
Small ribosomal subunit protein uS7

1

3

High-throughput

0.484

High

395118

DPO3E
DNA polymerase III subunit epsilon

1

2

High-throughput

0.484

High

490260

CLPP
ATP-dependent Clp protease proteolytic subunit

1

2

High-throughput

0.484

High

490818

GREA
Transcription elongation factor GreA

1

1

High-throughput

0.484

High

492740

RL1
Large ribosomal subunit protein uL1

1

3

High-throughput

0.484

High

494290

RS5
Small ribosomal subunit protein uS5

1

2

High-throughput

0.484

High

497414

CSPC
Cold shock-like protein CspC

1

4

High-throughput

0.484

High

497627

RLUC
Ribosomal large subunit pseudouridine synthase C

1

3

High-throughput

0.484

High

498340

FTSA
Cell division protein FtsA

1

1

High-throughput

0.484

High

501275

RL6
Large ribosomal subunit protein uL6

1

1

High-throughput

0.484

High

501612

RLUB
Ribosomal large subunit pseudouridine synthase B

1

3

High-throughput

0.484

High

501616

RL3
Large ribosomal subunit protein uL3

1

4

High-throughput

0.484

High

501618

RL22
Large ribosomal subunit protein uL22

1

3

High-throughput

0.484

High

501614

YHHX
Uncharacterized oxidoreductase YhhX

1

0

High-throughput

0.479

High

501619

YQJI
Transcriptional regulator YqjI

1

0

High-throughput

0.479

High

458783

FDHF
Formate dehydrogenase H

1

1

High-throughput

0.479

High

492613

RL19
Large ribosomal subunit protein bL19

1

2

High-throughput

0.479

High

492941

RL28
Large ribosomal subunit protein bL28

1

1

High-throughput

0.479

High

493250

RS10
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

494451

RS9
Small ribosomal subunit protein uS9

1

3

High-throughput

0.479

High

501617

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.479

High

382577

RS6
Small ribosomal subunit protein bS6

1

0

High-throughput

0.464

High

490889

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

491549

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

1

0

High-throughput

0.464

High

492242

PYRH
Uridylate kinase

1

0

High-throughput

0.464

High

493921

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.464

High

494891

TGT
Queuine tRNA-ribosyltransferase

1

0

High-throughput

0.464

High

496727

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

497101

DEAD
ATP-dependent RNA helicase DeaD

1

0

High-throughput

0.464

High

497990

YBCJ
Putative RNA-binding protein YbcJ

1

0

High-throughput

0.464

High

498556

HOLE
DNA polymerase III subunit theta

1

0

High-throughput

0.464

High

501602

RNR
Ribonuclease R

1

0

High-throughput

0.464

High

501605

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

1

0

High-throughput

0.464

High

501609

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.464

High

501624

RLMKL
Ribosomal RNA large subunit methyltransferase K/L [Includes: 23S rRNA m2G2445 methyltransferase

1

0

High-throughput

0.464

High

495575

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.458

High

495977

YFBU
UPF0304 protein YfbU

1

0

High-throughput

0.458

High

498305

PCNB
Poly(A) polymerase I

1

0

High-throughput

0.458

High

500641

RRAB
Regulator of ribonuclease activity B

1

0

High-throughput

0.458

High

501227

RL21
Large ribosomal subunit protein bL21

1

0

High-throughput

0.458

High

501611

RLMJ
Ribosomal RNA large subunit methyltransferase J

1

0

High-throughput

0.458

High

501621

CSRA
Carbon storage regulator

1

0

High-throughput

0.458

High

501628

MENI
1,4-dihydroxy-2-naphthoyl-CoA hydrolase

1

0

High-throughput

0.458

High

445414

DPO3X
DNA polymerase III subunit tau

1

1

High-throughput

0.442

High

501319

RS14
Small ribosomal subunit protein uS14

1

1

High-throughput

0.442

High

501599

SELB
Selenocysteine-specific elongation factor

1

2

High-throughput

0.442

High

501626

A2MG
Alpha-2-macroglobulin

1

2

High-throughput

0.442

High

491636

KPRS
Ribose-phosphate pyrophosphokinase

1

0

High-throughput

0.426

High

494955

TIG
Trigger factor

1

0

Small-scale

0.426

High

501601

MURG
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

2

0

High-throughput

0.324

High

499893

RL16
Large ribosomal subunit protein uL16

2

0

High-throughput

0.307

High

500101

DACA
D-alanyl-D-alanine carboxypeptidase DacA

2

0

High-throughput

0.307

High

501608

YEHZ
Glycine betaine-binding protein YehZ

1

0

High-throughput

0.279

Low

501610

HYBD
Hydrogenase 2 maturation protease

1

0

High-throughput

0.279

Low

501622

YBGP
Uncharacterized fimbrial chaperone YbgP

1

0

High-throughput

0.279

Low

491943

RPPH
RNA pyrophosphohydrolase

1

0

High-throughput

0.253

Low

495440

TRMB
tRNA

1

0

High-throughput

0.253

Low

498542

DNAG
DNA primase

1

0

High-throughput

0.253

Low

501600

SRLR
Glucitol operon repressor

1

0

High-throughput

0.253

Low

501623

YBJX
Uncharacterized protein YbjX

1

0

High-throughput

0.249

Low

501625

YNCE
Uncharacterized protein YncE

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025