HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 0.60 0.700

The method score is based on:

Property Details
Experiments 26618866, 31324722, 17110338, 29924966, 22038833
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
and 8 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 654
Hs

1 1480
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024