Protein: RL22
Large ribosomal subunit protein uL22 (50S ribosomal protein L22)

Gene: RL22, rplV
Organism: Escherichia coli K-12
Interactions: 129
UniProt ID: P61175

Gene Ontology (top 5):
GO:0002181 - cytoplasmic translation
GO:0003735 - structural constituent of ribosome
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006412 - translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

953317

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.625

High

610966

UBIG
Ubiquinone biosynthesis O-methyltransferase

2

0

High-throughput

0.606

High

384057

RL15
Large ribosomal subunit protein uL15

1

1

High-throughput

0.536

High

449878

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

1

0

High-throughput

0.513

High

457004

CHEA
Chemotaxis protein CheA

1

0

High-throughput

0.513

High

499556

YEEZ
Protein YeeZ

1

0

High-throughput

0.513

High

559590

FDHE
Protein FdhE

1

0

High-throughput

0.513

High

958603

FLAV
Flavodoxin 1

1

0

High-throughput

0.513

High

958609

MACA
Macrolide export protein MacA

1

0

High-throughput

0.513

High

395170

UVRD
DNA helicase II

1

2

High-throughput

0.484

High

421130

PNP
Polyribonucleotide nucleotidyltransferase

1

2

High-throughput

0.484

High

444323

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.484

High

450099

RF2
Peptide chain release factor RF2

1

3

High-throughput

0.484

High

473320

DNAJ
Chaperone protein DnaJ

1

3

High-throughput

0.484

High

491752

LPXA
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

1

1

High-throughput

0.484

High

495490

RHLB
ATP-dependent RNA helicase RhlB

1

5

High-throughput

0.484

High

495545

SYT
Threonine--tRNA ligase

1

2

High-throughput

0.484

High

495858

RPOC
DNA-directed RNA polymerase subunit beta'

1

1

High-throughput

0.484

High

496322

CSPG
Cold shock-like protein CspG

1

10

High-throughput

0.484

High

497119

DEAD
ATP-dependent RNA helicase DeaD

1

6

High-throughput

0.484

High

497280

ULAR
HTH-type transcriptional regulator UlaR

1

1

High-throughput

0.484

High

497440

CSPC
Cold shock-like protein CspC

1

10

High-throughput

0.484

High

497649

RLUC
Ribosomal large subunit pseudouridine synthase C

1

2

High-throughput

0.484

High

500031

MAP1
Methionine aminopeptidase

1

1

High-throughput

0.484

High

500855

PARC
DNA topoisomerase 4 subunit A

1

1

High-throughput

0.484

High

501618

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

3

High-throughput

0.484

High

501889

RLME
Ribosomal RNA large subunit methyltransferase E

1

1

High-throughput

0.484

High

569576

SELB
Selenocysteine-specific elongation factor

1

2

High-throughput

0.484

High

638584

RNR
Ribonuclease R

1

3

High-throughput

0.484

High

638615

SRMB
ATP-dependent RNA helicase SrmB

1

7

High-throughput

0.484

High

639469

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

1

1

High-throughput

0.484

High

649702

MUKB
Chromosome partition protein MukB

1

1

High-throughput

0.484

High

676568

MNME
tRNA modification GTPase MnmE

1

5

High-throughput

0.484

High

724355

GLMM
Phosphoglucosamine mutase

1

1

High-throughput

0.484

High

750368

AIDB
Putative acyl-CoA dehydrogenase AidB

1

1

High-throughput

0.484

High

785878

CBPA
Curved DNA-binding protein

1

2

High-throughput

0.484

High

788394

CSPB
Cold shock-like protein CspB

1

10

High-throughput

0.484

High

790849

RLUB
Ribosomal large subunit pseudouridine synthase B

1

2

High-throughput

0.484

High

953819

LEPA
Elongation factor 4

1

3

High-throughput

0.484

High

958604

RLMB
23S rRNA

1

3

High-throughput

0.484

High

958605

CLPB
Chaperone protein ClpB

1

5

High-throughput

0.484

High

490434

DEF
Peptide deformylase

1

0

Small-scale

0.480

High

361757

PHSM
Maltodextrin phosphorylase

1

0

High-throughput

0.464

High

365842

RPOD
RNA polymerase sigma factor RpoD

1

0

High-throughput

0.464

High

368796

SYW
Tryptophan--tRNA ligase

1

0

High-throughput

0.464

High

368969

SYGA
Glycine--tRNA ligase alpha subunit

1

0

High-throughput

0.464

High

395093

DNAA
Chromosomal replication initiator protein DnaA

1

0

High-throughput

0.464

High

445390

BIRA
Bifunctional ligase/repressor BirA

1

0

High-throughput

0.464

High

489319

ACP
Acyl carrier protein

1

0

High-throughput

0.464

High

490497

DTD
D-aminoacyl-tRNA deacylase

1

0

High-throughput

0.464

High

490685

FABZ
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

1

0

High-throughput

0.464

High

490711

FIS
DNA-binding protein Fis

1

0

High-throughput

0.464

High

490911

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

490973

IHFB
Integration host factor subunit beta

1

0

High-throughput

0.464

High

491514

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

1

0

High-throughput

0.464

High

491560

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

1

0

High-throughput

0.464

High

491824

MURA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

1

0

High-throughput

0.464

High

491954

RPPH
RNA pyrophosphohydrolase

1

0

High-throughput

0.464

High

492084

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.464

High

492145

HSLV
ATP-dependent protease subunit HslV

1

0

High-throughput

0.464

High

492172

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.464

High

492256

PYRH
Uridylate kinase

1

0

High-throughput

0.464

High

494900

TGT
Queuine tRNA-ribosyltransferase

1

0

High-throughput

0.464

High

495370

UVRC
UvrABC system protein C

1

0

High-throughput

0.464

High

495939

RPOB
DNA-directed RNA polymerase subunit beta

1

0

High-throughput

0.464

High

496739

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

496870

PPIC
Peptidyl-prolyl cis-trans isomerase C

1

0

High-throughput

0.464

High

496923

LON
Lon protease

1

0

High-throughput

0.464

High

497160

ACCD
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

1

0

High-throughput

0.464

High

497210

FTSE
Cell division ATP-binding protein FtsE

1

0

High-throughput

0.464

High

498005

YBCJ
Putative RNA-binding protein YbcJ

1

0

High-throughput

0.464

High

498174

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.464

High

498277

ACCA
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

1

0

High-throughput

0.464

High

499169

HNS
DNA-binding protein H-NS

1

0

High-throughput

0.464

High

499211

HSLR
Heat shock protein 15

1

0

High-throughput

0.464

High

499742

YIBL
Uncharacterized protein YibL

1

0

High-throughput

0.464

High

499957

RL23
Large ribosomal subunit protein uL23

1

0

High-throughput

0.464

High

500387

FUCM
L-fucose mutarotase

1

0

High-throughput

0.464

High

500492

SKP
Chaperone protein Skp

1

0

High-throughput

0.464

High

500713

NUSA
Transcription termination/antitermination protein NusA

1

0

High-throughput

0.464

High

500736

NUSG
Transcription termination/antitermination protein NusG

1

0

High-throughput

0.464

High

501110

SPOT
Bifunctional

1

0

High-throughput

0.464

High

515982

RCSB
Transcriptional regulatory protein RcsB

1

0

High-throughput

0.464

High

521495

SECA
Protein translocase subunit SecA

1

0

High-throughput

0.464

High

597642

ICLR
Transcriptional repressor IclR

1

0

High-throughput

0.464

High

602722

GLMS
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.464

High

612850

PNCB
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.464

High

638634

RNE
Ribonuclease E

1

0

High-throughput

0.464

High

788377

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.464

High

811770

RSGA
Small ribosomal subunit biogenesis GTPase RsgA

1

0

High-throughput

0.464

High

852557

TSAC
Threonylcarbamoyl-AMP synthase

1

0

High-throughput

0.464

High

958602

RISB
6,7-dimethyl-8-ribityllumazine synthase

1

0

High-throughput

0.464

High

958606

PTNAB
PTS system mannose-specific EIIAB component

1

0

High-throughput

0.464

High

958607

GNGF
Putative gluconeogenesis factor

1

0

High-throughput

0.464

High

501543

SSB
Single-stranded DNA-binding protein

1

1

High-throughput

0.445

High

571335

TOP3
DNA topoisomerase 3

1

1

High-throughput

0.442

High

578599

SRLR
Glucitol operon repressor

1

1

High-throughput

0.442

High

491687

KPRS
Ribose-phosphate pyrophosphokinase

1

0

High-throughput

0.426

High

494993

TIG
Trigger factor

1

0

Small-scale

0.426

High

732774

MOBA
Molybdenum cofactor guanylyltransferase

1

0

High-throughput

0.426

High

418558

NLPA
Lipoprotein 28

1

0

High-throughput

0.279

Low

479590

YJAA
Uncharacterized protein YjaA

1

0

High-throughput

0.279

Low

726728

CBRC
UPF0167 protein CbrC

1

0

High-throughput

0.279

Low

732770

YIIX
Uncharacterized protein YiiX

1

0

High-throughput

0.279

Low

958610

YMFM
Uncharacterized protein YmfM

1

0

High-throughput

0.279

Low

491794

MOAC
Cyclic pyranopterin monophosphate synthase

1

0

High-throughput

0.253

Low

492050

PLSB
Glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.253

Low

494581

RNPA
Ribonuclease P protein component

1

0

High-throughput

0.253

Low

495147

RAPZ
RNase adapter protein RapZ

1

0

High-throughput

0.253

Low

495290

YACL
UPF0231 protein YacL

1

0

High-throughput

0.253

Low

495451

TRMB
tRNA

1

0

High-throughput

0.253

Low

497309

ZNUC
Zinc import ATP-binding protein ZnuC

1

0

High-throughput

0.253

Low

498912

KDTA
3-deoxy-D-manno-octulosonic acid transferase

1

0

High-throughput

0.253

Low

499031

MBHM
Hydrogenase-2 large chain

1

0

High-throughput

0.253

Low

499690

FIMB
Type 1 fimbriae regulatory protein FimB

1

0

High-throughput

0.253

Low

500167

DCM
DNA-cytosine methyltransferase

1

0

High-throughput

0.253

Low

500195

DMA
DNA adenine methylase

1

0

High-throughput

0.253

Low

516002

RCSA
Transcriptional regulatory protein RcsA

1

0

High-throughput

0.253

Low

641743

RECJ
Single-stranded-DNA-specific exonuclease RecJ

1

0

High-throughput

0.253

Low

704158

HOLA
DNA polymerase III subunit delta

1

0

High-throughput

0.253

Low

705896

HOLC
DNA polymerase III subunit chi

1

0

High-throughput

0.253

Low

750385

LLDD
L-lactate dehydrogenase

1

0

High-throughput

0.253

Low

751951

DUSC
tRNA-dihydrouridine(16) synthase

1

0

High-throughput

0.253

Low

958601

LOLA
Outer-membrane lipoprotein carrier protein

1

0

High-throughput

0.253

Low

958608

YBJX
Uncharacterized protein YbjX

1

0

High-throughput

0.253

Low

958611

PAAX
Transcriptional repressor PaaX

1

0

High-throughput

0.253

Low

958612

RLHA
23S rRNA 5-hydroxycytidine C2501 synthase

1

0

High-throughput

0.253

Low

958613

LYSAC
Peptidyl-lysine N-acetyltransferase PatZ

1

0

High-throughput

0.253

Low

958614

YGCP
Uncharacterized protein YgcP

1

0

High-throughput

0.253

Low


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Last updated: 11Aug2025