Protein: RM22
Large ribosomal subunit protein uL22m (39S ribosomal protein L22, mitochondrial) (L22mt) (MRP-L22) (39S ribosomal protein L25, mitochondrial) (L25mt) (MRP-L25)

Gene: RM22, MRPL22
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q9NWU5

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003735 - structural constituent of ribosome
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005762 - mitochondrial large ribosomal subunit

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1418264

RM04
Large ribosomal subunit protein uL4m

3

1

High-throughput

0.861

High

1451508

RM39
Large ribosomal subunit protein mL39

3

1

High-throughput

0.667

High

1446051

RT30
Large ribosomal subunit protein mL65

4

0

High-throughput

0.661

High

1451520

RM42
Large ribosomal subunit protein mL42

4

0

High-throughput

0.661

High

1328310

RM50
Large ribosomal subunit protein mL50

3

0

High-throughput

0.646

High

969485

RS8
Small ribosomal subunit protein eS8

3

0

High-throughput

0.638

High

1439605

RM47
Large ribosomal subunit protein uL29m

3

0

High-throughput

0.638

High

914775

RM12
Large ribosomal subunit protein bL12m

3

0

High-throughput

0.634

High

1281354

RM10
Large ribosomal subunit protein uL10m

3

0

High-throughput

0.634

High

1312782

RM41
Large ribosomal subunit protein mL41

3

0

High-throughput

0.634

High

1418152

RM13
Large ribosomal subunit protein uL13m

3

0

High-throughput

0.622

High

1451516

YBOX2
Y-box-binding protein 2

2

5

High-throughput

0.601

High

1451506

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.586

High

1016261

RL19
Large ribosomal subunit protein eL19

2

0

High-throughput

0.576

High

1196175

RM51
Large ribosomal subunit protein mL51

2

0

High-throughput

0.576

High

1213359

RM02
Large ribosomal subunit protein uL2m

2

0

High-throughput

0.576

High

1287562

RM52
Large ribosomal subunit protein mL52

2

0

High-throughput

0.576

High

1430521

RM18
Large ribosomal subunit protein uL18m

2

0

High-throughput

0.576

High

1451510

RM27
Large ribosomal subunit protein bL27m

2

0

High-throughput

0.576

High

1048730

SSBP
Single-stranded DNA-binding protein, mitochondrial

2

1

High-throughput

0.571

High

1058321

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

Small-scale

0.559

High

1123455

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.559

High

1451511

MRES1
Mitochondrial transcription rescue factor 1

2

0

High-throughput

0.559

High

1024210

TFAM
Transcription factor A, mitochondrial

2

0

High-throughput

0.547

High

994834

YBOX1
Y-box-binding protein 1

1

5

High-throughput

0.536

High

1437365

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.536

High

373299

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.533

High

280064

RM33
Large ribosomal subunit protein bL33m

1

0

High-throughput

0.513

High

521977

H14
Histone H1.4

1

0

High-throughput

0.513

High

859093

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

964166

RL37
Large ribosomal subunit protein eL37

1

0

High-throughput

0.513

High

1009340

PRR3
Proline-rich protein 3

1

0

High-throughput

0.513

High

1062135

SRSF4
Serine/arginine-rich splicing factor 4

1

0

High-throughput

0.513

High

1148807

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

0

High-throughput

0.513

High

1158314

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

1270540

MARK2
Serine/threonine-protein kinase MARK2

1

0

High-throughput

0.513

High

1347103

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.513

High

1349564

RM30
Large ribosomal subunit protein uL30m

1

0

High-throughput

0.513

High

1389022

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1389297

RM53
Large ribosomal subunit protein mL53

1

0

High-throughput

0.513

High

1418207

RM09
Large ribosomal subunit protein bL9m

1

0

High-throughput

0.513

High

1419657

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.513

High

1149206

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.493

High

1146266

ZMY11
Zinc finger MYND domain-containing protein 11

1

2

High-throughput

0.489

High

282107

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

287395

RF1M
Peptide chain release factor 1, mitochondrial

1

3

High-throughput

0.479

High

856406

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

1083778

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

1138692

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1215859

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1234548

MRM1
rRNA methyltransferase 1, mitochondrial

1

2

High-throughput

0.479

High

1381749

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1386037

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

1387234

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

1389917

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

1401640

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1432636

MTRFR
Mitochondrial translation release factor in rescue

1

3

High-throughput

0.479

High

1438041

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

1451509

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

1

High-throughput

0.479

High

1451513

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

3

High-throughput

0.479

High

1451519

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

66314

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

183755

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

243106

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

276005

DUS11
RNA/RNP complex-1-interacting phosphatase

1

0

High-throughput

0.458

High

279949

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

283991

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

351018

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

473130

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

485459

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

487814

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

505461

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

519251

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

538003

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

828986

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841992

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

852057

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882923

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

960275

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.458

High

1087589

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

1088584

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.458

High

1094140

RM28
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.458

High

1096245

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

1100456

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1117865

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1138104

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

1162592

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1194414

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

1241357

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

1271882

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1279554

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

0

High-throughput

0.458

High

1310466

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

1334997

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1341197

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.458

High

1367414

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1387764

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.458

High

1388294

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1388432

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1392771

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.458

High

1412458

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1414104

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1415690

TR61B
tRNA

1

0

High-throughput

0.458

High

1416565

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1418908

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1428751

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1429803

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

1431979

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1433739

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1435809

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1436113

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1446262

NGRN
Neugrin

1

0

High-throughput

0.458

High

1450443

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1451449

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1451517

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

1214817

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

High-throughput

0.445

High

1450574

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.445

High

406719

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

1255798

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1368645

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.437

High

1368724

DLG3
Disks large homolog 3

1

1

High-throughput

0.437

High

430429

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

653610

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

631512

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.298

High

846103

GLP1R
Glucagon-like peptide 1 receptor

1

0

Small-scale

0.288

High

1260446

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.279

Low

1451515

KLF15
Krueppel-like factor 15

1

0

High-throughput

0.261

Low

155361

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.249

Low

282319

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.249

Low

316073

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

325132

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

418469

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

519568

MYBB
Myb-related protein B

1

0

High-throughput

0.249

Low

831525

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

879530

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

942923

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

971177

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1015841

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.249

Low

1086826

BPTF
Nucleosome-remodeling factor subunit BPTF

1

0

High-throughput

0.249

Low

1095821

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.249

Low

1216631

LIN9
Protein lin-9 homolog

1

0

High-throughput

0.249

Low

1227567

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.249

Low

1312694

BAP18
BPTF-associated chromatin complex component 1

1

0

High-throughput

0.249

Low

1380200

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.249

Low

1386604

OPTN
Optineurin

1

0

High-throughput

0.249

Low

1390731

DYL2
Dynein light chain 2, cytoplasmic

1

0

High-throughput

0.249

Low

1392572

LIN37
Protein lin-37 homolog

1

0

High-throughput

0.249

Low

1393757

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1411734

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.249

Low

1413348

MTA3
Metastasis-associated protein MTA3

1

0

High-throughput

0.249

Low

1430823

BC11A
BCL11 transcription factor A

1

0

High-throughput

0.249

Low

1435860

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

0

High-throughput

0.249

Low

1446969

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1447340

ANLN
Anillin

1

0

High-throughput

0.249

Low

1451507

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

1451512

MBD2
Methyl-CpG-binding domain protein 2

1

0

High-throughput

0.249

Low

1451514

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1451518

TRI17
E3 ubiquitin-protein ligase TRIM17

1

0

Small-scale

0.249

Low

1242251

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025