HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016020 - membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 4544
+	Hs
		503960 HSP7C_HUMAN (26-637): 0: 916: 66.02		LRP1_HUMAN (24-4544): 0: 3520: 100.00
+	Hs
		502002 BIP_HUMAN (19-654): 0: 914: 100.00		NOTC2_HUMAN (2441-2811): 3.71e-13: 79.1: 10.70
+	Hs
		351041 BIP_HUMAN (19-654): 0: 914: 100.00		LDLR_HUMAN (4062-4338): 4.81e-10: 68.3: 11.95
+	Hs
		502624 BIP_HUMAN (19-654): 0: 914: 100.00		LRP1B_HUMAN (2-280): 8.74e-09: 64.5: 16.93