Protein: H2A2A
Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o)

Gene: H2A2A, H2AC18
Organism: Homo sapiens
Interactions: 185
UniProt ID: Q6FI13

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0030527 - structural constituent of chromatin
GO:0031507 - heterochromatin formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

979828

H4
Histone H4

5

15

High-throughput

0.906

High

980845

H2B1C
Histone H2B type 1-C/E/F/G/I

5

20

High-throughput

0.906

High

1232720

H2B1N
Histone H2B type 1-N

4

20

High-throughput

0.874

High

1162987

H2B2E
Histone H2B type 2-E

4

20

Small-scale

0.873

High

1232684

H32
Histone H3.2

4

20

High-throughput

0.873

High

449735

H2B1J
Histone H2B type 1-J

3

20

High-throughput

0.847

High

1232718

RING2
E3 ubiquitin-protein ligase RING2

3

20

Small-scale

0.840

High

256895

H2B1K
Histone H2B type 1-K

3

20

High-throughput

0.827

High

521746

H14
Histone H1.4

3

20

High-throughput

0.827

High

998433

H31
Histone H3.1

3

20

High-throughput

0.827

High

1161903

H31T
Histone H3.1t

3

20

High-throughput

0.827

High

888128

MCM2
DNA replication licensing factor MCM2

2

20

High-throughput

0.789

High

1065240

SSRP1
FACT complex subunit SSRP1

2

20

High-throughput

0.789

High

1232729

WDR76
WD repeat-containing protein 76

2

15

High-throughput

0.789

High

1232747

SP16H
FACT complex subunit SPT16

2

9

High-throughput

0.789

High

508135

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

17

High-throughput

0.768

High

765622

BMI1
Polycomb complex protein BMI-1

2

20

Small-scale

0.768

High

1232693

RN168
E3 ubiquitin-protein ligase RNF168

2

12

Small-scale

0.768

High

419034

H2A1B
Histone H2A type 1-B/E

2

19

High-throughput

0.754

High

502388

H2A1
Histone H2A type 1

2

19

High-throughput

0.754

High

634035

H2A1D
Histone H2A type 1-D

2

19

High-throughput

0.754

High

659903

H2B1O
Histone H2B type 1-O

2

20

High-throughput

0.754

High

754877

H2B1B
Histone H2B type 1-B

2

20

High-throughput

0.754

High

946805

H2B1D
Histone H2B type 1-D

2

20

High-throughput

0.754

High

1232687

H2A3
Histone H2A type 3

2

19

High-throughput

0.754

High

1232695

H2B3B
Histone H2B type 3-B

2

20

High-throughput

0.754

High

1232723

H2B1L
Histone H2B type 1-L

2

20

High-throughput

0.754

High

320341

PHF14
PHD finger protein 14

1

8

High-throughput

0.691

High

1066351

RBBP4
Histone-binding protein RBBP4

1

8

High-throughput

0.691

High

1232689

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

20

Small-scale

0.691

High

1232690

H2A2B
Histone H2A type 2-B

1

19

High-throughput

0.691

High

1232702

GEMI5
Gem-associated protein 5

1

7

High-throughput

0.691

High

1232724

COR1B
Coronin-1B

1

10

High-throughput

0.691

High

1086612

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

4

Small-scale

0.665

High

1232750

U3KQK0
Histone H2B

1

20

High-throughput

0.665

High

261418

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

7

Small-scale

0.647

High

1217864

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

18

Small-scale

0.647

High

1232698

RN169
E3 ubiquitin-protein ligase RNF169

1

9

Small-scale

0.647

High

1232704

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

Small-scale

0.647

High

187104

PPM1G
Protein phosphatase 1G

2

11

High-throughput

0.628

High

1232714

IPO9
Importin-9

1

9

High-throughput

0.618

High

277715

H2AY
Core histone macro-H2A.1

1

20

High-throughput

0.618

High

595472

H15
Histone H1.5

1

20

High-throughput

0.618

High

595799

H13
Histone H1.3

1

20

High-throughput

0.618

High

596161

H12
Histone H1.2

1

20

High-throughput

0.618

High

649335

H1T
Histone H1t

1

20

High-throughput

0.618

High

845317

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

6

High-throughput

0.618

High

943372

H2BFS
Histone H2B type F-S

1

20

High-throughput

0.618

High

987073

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

18

High-throughput

0.618

High

987381

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

17

High-throughput

0.618

High

1016944

H33
Histone H3.3

1

20

High-throughput

0.618

High

1037204

H11
Histone H1.1

1

20

High-throughput

0.618

High

1109819

HDAC1
Histone deacetylase 1

1

14

Small-scale

0.618

High

1162803

H2A2C
Histone H2A type 2-C

1

19

High-throughput

0.618

High

1208837

H2B2F
Histone H2B type 2-F

1

20

High-throughput

0.618

High

1232679

H2A2A
Histone H2A type 2-A

1

19

High-throughput

0.618

High

1232680

H3C
Histone H3.3C

1

20

High-throughput

0.618

High

1232705

H2A1C
Histone H2A type 1-C

1

19

High-throughput

0.618

High

1232706

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.618

High

1232708

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

10

High-throughput

0.618

High

1232711

H2A1H
Histone H2A type 1-H

1

19

High-throughput

0.618

High

1232716

H2A1A
Histone H2A type 1-A

1

19

High-throughput

0.618

High

1232721

H2A1J
Histone H2A type 1-J

1

19

High-throughput

0.618

High

1232722

H2B1M
Histone H2B type 1-M

1

20

High-throughput

0.618

High

1232726

H2AJ
Histone H2A.J

1

19

High-throughput

0.618

High

601728

HMGA1
High mobility group protein HMG-I/HMG-Y

2

6

High-throughput

0.611

High

422319

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.602

High

129178

MEN1
Menin

1

0

Small-scale

0.586

High

363418

EGFR
Epidermal growth factor receptor

2

2

Small-scale

0.584

High

436686

KPCB
Protein kinase C beta type

2

10

High-throughput

0.571

High

702355

ELK4
ETS domain-containing protein Elk-4

2

9

High-throughput

0.571

High

1232719

DNJC2
DnaJ homolog subfamily C member 2

1

7

Small-scale

0.561

High

190151

TNC18
Trinucleotide repeat-containing gene 18 protein

1

9

High-throughput

0.553

High

651362

CBL
E3 ubiquitin-protein ligase CBL

1

10

High-throughput

0.553

High

1232700

NUP43
Nucleoporin Nup43

1

12

High-throughput

0.553

High

290327

KS6A4
Ribosomal protein S6 kinase alpha-4

1

8

High-throughput

0.536

High

471083

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.536

High

481307

HMGB1
High mobility group protein B1

1

20

High-throughput

0.536

High

594022

NCK1
SH2/SH3 adapter protein NCK1

1

3

High-throughput

0.536

High

755734

MCM4
DNA replication licensing factor MCM4

1

20

High-throughput

0.536

High

832909

CETN2
Centrin-2

1

6

High-throughput

0.536

High

1032823

XPC
DNA repair protein complementing XP-C cells

1

5

High-throughput

0.536

High

1091683

MYO1E
Unconventional myosin-Ie

1

4

High-throughput

0.536

High

1100832

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.536

High

1134616

NUMA1
Nuclear mitotic apparatus protein 1

1

12

High-throughput

0.536

High

1187973

GON4L
GON-4-like protein

1

6

High-throughput

0.536

High

1232682

MMS22
Protein MMS22-like

1

4

High-throughput

0.536

High

1232691

APLF
Aprataxin and PNK-like factor

1

4

High-throughput

0.536

High

1232694

MIER1
Mesoderm induction early response protein 1

1

15

High-throughput

0.536

High

1232728

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

1232733

HM20A
High mobility group protein 20A

1

20

High-throughput

0.536

High

1232740

PARP2
Poly [ADP-ribose] polymerase 2

1

13

High-throughput

0.536

High

1232743

RUVB2
RuvB-like 2

1

9

High-throughput

0.536

High

1232749

EPN1
Epsin-1

1

3

High-throughput

0.536

High

163121

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.513

High

1107553

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

High-throughput

0.513

High

1136739

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.513

High

1232686

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.513

High

1232744

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

344442

IL33
Interleukin-33

1

1

Small-scale

0.501

High

487428

PARP1
Poly [ADP-ribose] polymerase 1

1

20

Small-scale

0.501

High

1232712

ANM6
Protein arginine N-methyltransferase 6

1

5

High-throughput

0.501

High

1232732

MSL2
E3 ubiquitin-protein ligase MSL2

1

1

Small-scale

0.501

High

1232746

NOC2L
Nucleolar complex protein 2 homolog

1

3

Small-scale

0.501

High

1232748

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

14

Small-scale

0.501

High

166161

AIM2
Interferon-inducible protein AIM2

1

2

High-throughput

0.489

High

329456

EPN2
Epsin-2

1

4

High-throughput

0.489

High

348143

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

14

High-throughput

0.489

High

909046

NEK4
Serine/threonine-protein kinase Nek4

1

16

High-throughput

0.489

High

1012863

RT09
Small ribosomal subunit protein uS9m

1

4

High-throughput

0.489

High

1180277

ATG2A
Autophagy-related protein 2 homolog A

1

1

High-throughput

0.489

High

1232681

CP087
UPF0547 protein C16orf87

1

4

High-throughput

0.489

High

1232697

NECP1
Adaptin ear-binding coat-associated protein 1

1

1

High-throughput

0.489

High

1232703

TRI41
E3 ubiquitin-protein ligase TRIM41

1

3

High-throughput

0.489

High

1232710

TONSL
Tonsoku-like protein

1

13

High-throughput

0.489

High

1232715

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.489

High

1232717

FNBP1
Formin-binding protein 1

1

4

High-throughput

0.489

High

1232739

CFDP1
Craniofacial development protein 1

1

4

High-throughput

0.489

High

64799

EPAB2
Embryonic polyadenylate-binding protein 2

1

9

High-throughput

0.479

High

130768

TAF4
Transcription initiation factor TFIID subunit 4

1

6

High-throughput

0.479

High

226799

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

3

High-throughput

0.479

High

324923

HEXI1
Protein HEXIM1

1

12

High-throughput

0.479

High

426516

HMGN2
Non-histone chromosomal protein HMG-17

1

10

High-throughput

0.479

High

616335

RCC1
Regulator of chromosome condensation

1

5

High-throughput

0.479

High

635534

NEBU
Nebulin

1

10

High-throughput

0.479

High

651672

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

3

Small-scale

0.479

High

687252

HMGB2
High mobility group protein B2

1

20

High-throughput

0.479

High

755958

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.479

High

853700

MK08
Mitogen-activated protein kinase 8

1

5

High-throughput

0.479

High

896793

DYN2
Dynamin-2

1

3

High-throughput

0.479

High

897861

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.479

High

967214

RRAS2
Ras-related protein R-Ras2

1

2

High-throughput

0.479

High

975749

RL7A
Large ribosomal subunit protein eL8

1

5

High-throughput

0.479

High

983840

RBX1
E3 ubiquitin-protein ligase RBX1

1

4

High-throughput

0.479

High

1113390

CUL3
Cullin-3

1

14

High-throughput

0.479

High

1120202

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

Small-scale

0.479

High

1137350

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.479

High

1141172

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1141689

EEA1
Early endosome antigen 1

1

15

High-throughput

0.479

High

1194148

LARP7
La-related protein 7

1

20

High-throughput

0.479

High

1201242

ESCO2
N-acetyltransferase ESCO2

1

1

Small-scale

0.479

High

1229524

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1232685

MEPCE
7SK snRNA methylphosphate capping enzyme

1

12

High-throughput

0.479

High

1232688

SLN11
Schlafen family member 11

1

6

High-throughput

0.479

High

1232692

SRRM1
Serine/arginine repetitive matrix protein 1

1

11

High-throughput

0.479

High

1232707

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1232709

AURKB
Aurora kinase B

1

10

Small-scale

0.479

High

1232713

CI072
Guanine nucleotide exchange factor C9orf72

1

10

High-throughput

0.479

High

1232727

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

17

High-throughput

0.479

High

1232731

RC3H2
Roquin-2

1

13

High-throughput

0.479

High

1232742

RL26L
Ribosomal protein uL24-like

1

7

High-throughput

0.479

High

252461

DIAP1
Protein diaphanous homolog 1

1

0

High-throughput

0.458

High

1120133

CYLC2
Cylicin-2

1

0

High-throughput

0.458

High

1232737

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1232741

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

14

Small-scale

0.457

High

987706

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.445

High

1103232

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.445

High

1209253

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1232730

LN28A
Protein lin-28 homolog A

1

20

High-throughput

0.445

High

157497

CTRO
Citron Rho-interacting kinase

1

11

High-throughput

0.437

High

272256

OBSL1
Obscurin-like protein 1

1

5

High-throughput

0.437

High

460562

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

4

High-throughput

0.437

High

660648

IF4B
Eukaryotic translation initiation factor 4B

1

9

High-throughput

0.437

High

861195

MAP1B
Microtubule-associated protein 1B

1

8

High-throughput

0.437

High

868537

RL29
Large ribosomal subunit protein eL29

1

1

High-throughput

0.437

High

879188

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.437

High

1134949

CUL7
Cullin-7

1

1

High-throughput

0.437

High

1137772

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

1215663

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

1232683

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

1232701

SMRC2
SWI/SNF complex subunit SMARCC2

1

13

High-throughput

0.437

High

1232735

ANLN
Anillin

1

3

High-throughput

0.437

High

1232738

DAPLE
Protein Daple

1

20

High-throughput

0.437

High

255076

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.407

High

1232696

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.279

Low

1232699

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.279

Low

1232734

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

0

High-throughput

0.279

Low

1232736

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.279

Low

1232745

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.279

Low

178635

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.249

Low

271536

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.249

Low

972712

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.249

Low

1053372

CTSL2
CTD small phosphatase-like protein 2

1

0

Small-scale

0.249

Low

1232725

CNPY3
Protein canopy homolog 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025