HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 81
+	Hs
		501951 BIP_HUMAN (19-654): 0: 914: 100.00		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		501952 BIP_HUMAN (19-654): 0: 914: 100.00		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		713983 HS71L_HUMAN (24-647): 0: 922: 63.16		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		474905 HSP7C_HUMAN (26-637): 0: 916: 66.02		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		504136 HSP7C_HUMAN (26-637): 0: 916: 66.02		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Ce
		450538 HSP1_CAEEL (30-637): 0: 906: 64.65		NEDD8_CAEEL (1-77): 7.56e-34: 112: 87.01
+	Hs
		564084 HSP76_HUMAN (25-635): 0: 915: 62.54		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00