HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0030335 - positive regulation of cell migration
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 839
+	Hs
		384372 HS71L_HUMAN (24-647): 0: 922: 63.16		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		384163 HSP7C_HUMAN (26-637): 0: 916: 66.02		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		384219 HSP76_HUMAN (25-635): 0: 915: 62.54		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		384161 BIP_HUMAN (19-654): 0: 914: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		503438 HSP7C_HUMAN (26-637): 0: 916: 66.02		FGFR3_HUMAN (140-838): 3.83e-170: 514: 23.73
+	Hs
		507880 HS71L_HUMAN (24-647): 0: 922: 63.16		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		507836 HSP76_HUMAN (25-635): 0: 915: 62.54		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		507924 HSP72_HUMAN (25-636): 0: 905: 64.51		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		434123 BIP_HUMAN (19-654): 0: 914: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		501990 BIP_HUMAN (19-654): 0: 914: 100.00		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		411284 BIP_HUMAN (19-654): 0: 914: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435511 HSP7C_HUMAN (26-637): 0: 916: 66.02		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		435510 BIP_HUMAN (19-654): 0: 914: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Rn
		419257 BIP_RAT (1-654): 0: 918: 98.47		INSR_RAT (513-824): 3.31e-62: 230: 38.80
+	Rn
		544811 HSP7C_RAT (26-637): 0: 916: 66.02		INSR_RAT (513-824): 3.31e-62: 230: 38.80
+	Hs
		502677 BIP_HUMAN (19-654): 0: 914: 100.00		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	At
		612329 HS701_ARATH (28-654): 0: 916: 61.46		BRL2_ARATH (6-173): 1.69e-15: 83.3: 16.67