Protein: H2A3
Histone H2A type 3 (H2A-clustered histone 25)

Gene: H2A3, H2AC25
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q7L7L0

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0006337 - nucleosome disassembly
GO:0030527 - structural constituent of chromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1272818

H2B1L
Histone H2B type 1-L

3

20

High-throughput

0.827

High

256909

H2B1K
Histone H2B type 1-K

2

20

High-throughput

0.754

High

419048

H2A1B
Histone H2A type 1-B/E

2

19

High-throughput

0.754

High

946819

H2B1D
Histone H2B type 1-D

2

20

High-throughput

0.754

High

979887

H4
Histone H4

2

15

High-throughput

0.754

High

998476

H31
Histone H3.1

2

20

High-throughput

0.754

High

1161914

H31T
Histone H3.1t

2

20

Small-scale

0.754

High

1162813

H2A2C
Histone H2A type 2-C

2

19

High-throughput

0.754

High

1163014

H2B2E
Histone H2B type 2-E

2

20

High-throughput

0.754

High

1232687

H2A2A
Histone H2A type 2-A

2

19

High-throughput

0.754

High

1272802

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

20

Small-scale

0.691

High

990974

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

4

Small-scale

0.666

High

853320

CBX5
Chromobox protein homolog 5

1

19

Small-scale

0.647

High

1272803

RN168
E3 ubiquitin-protein ligase RNF168

1

12

Small-scale

0.647

High

1065259

SSRP1
FACT complex subunit SSRP1

1

20

Small-scale

0.646

High

1272828

SP16H
FACT complex subunit SPT16

1

9

Small-scale

0.646

High

449744

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.618

High

502405

H2A1
Histone H2A type 1

1

19

High-throughput

0.618

High

521776

H14
Histone H1.4

1

20

High-throughput

0.618

High

595488

H15
Histone H1.5

1

20

High-throughput

0.618

High

595811

H13
Histone H1.3

1

20

High-throughput

0.618

High

596191

H12
Histone H1.2

1

20

High-throughput

0.618

High

634040

H2A1D
Histone H2A type 1-D

1

19

High-throughput

0.618

High

649350

H1T
Histone H1t

1

20

High-throughput

0.618

High

659911

H2B1O
Histone H2B type 1-O

1

20

High-throughput

0.618

High

754889

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

888153

MCM2
DNA replication licensing factor MCM2

1

20

High-throughput

0.618

High

943380

H2BFS
Histone H2B type F-S

1

20

High-throughput

0.618

High

980876

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

987089

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

18

High-throughput

0.618

High

987394

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

17

High-throughput

0.618

High

1016978

H33
Histone H3.3

1

20

High-throughput

0.618

High

1037233

H11
Histone H1.1

1

20

High-throughput

0.618

High

1208845

H2B2F
Histone H2B type 2-F

1

20

High-throughput

0.618

High

1239448

H3C
Histone H3.3C

1

20

High-throughput

0.618

High

1258868

H32
Histone H3.2

1

20

High-throughput

0.618

High

1272804

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.618

High

1272808

H2A1C
Histone H2A type 1-C

1

20

High-throughput

0.618

High

1272809

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.618

High

1272811

H2A1H
Histone H2A type 1-H

1

19

High-throughput

0.618

High

1272813

H2A1A
Histone H2A type 1-A

1

19

High-throughput

0.618

High

1272814

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.618

High

1272815

H2B1N
Histone H2B type 1-N

1

20

High-throughput

0.618

High

1272816

H2A1J
Histone H2A type 1-J

1

19

High-throughput

0.618

High

1272817

H2B1M
Histone H2B type 1-M

1

20

High-throughput

0.618

High

1272819

H2AJ
Histone H2A.J

1

19

High-throughput

0.618

High

1272825

RAD18
E3 ubiquitin-protein ligase RAD18

1

4

High-throughput

0.618

High

1272826

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.618

High

436694

KPCB
Protein kinase C beta type

2

10

High-throughput

0.571

High

702359

ELK4
ETS domain-containing protein Elk-4

2

9

High-throughput

0.571

High

1272822

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

2

10

High-throughput

0.571

High

1272827

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

3

High-throughput

0.571

High

908134

KS6A3
Ribosomal protein S6 kinase alpha-3

2

8

High-throughput

0.521

High

1145881

RBP1
RalA-binding protein 1

2

4

High-throughput

0.521

High

909060

NEK4
Serine/threonine-protein kinase Nek4

1

16

High-throughput

0.489

High

324952

HEXI1
Protein HEXIM1

1

12

High-throughput

0.479

High

565415

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

571678

HCLS1
Hematopoietic lineage cell-specific protein

1

10

High-throughput

0.479

High

755970

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.479

High

975775

RL7A
Large ribosomal subunit protein eL8

1

5

High-throughput

0.479

High

1115764

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.479

High

1120217

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

Small-scale

0.479

High

1194179

LARP7
La-related protein 7

1

20

High-throughput

0.479

High

1271700

MEPCE
7SK snRNA methylphosphate capping enzyme

1

12

High-throughput

0.479

High

1272801

DPPA2
Developmental pluripotency-associated protein 2

1

3

High-throughput

0.479

High

1272806

SERB1
SERPINE1 mRNA-binding protein 1

1

11

High-throughput

0.479

High

1272807

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.479

High

1272812

CI072
Guanine nucleotide exchange factor C9orf72

1

10

High-throughput

0.479

High

1272820

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

17

High-throughput

0.479

High

1272823

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

5

High-throughput

0.479

High

1272824

DUOX2
Dual oxidase 2

1

3

High-throughput

0.479

High

940450

TCL1A
T-cell leukemia/lymphoma protein 1A

1

0

High-throughput

0.460

High

1135722

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1208774

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

1

Small-scale

0.457

High

1063798

LG3BP
Galectin-3-binding protein

1

6

High-throughput

0.445

High

157543

CTRO
Citron Rho-interacting kinase

1

11

High-throughput

0.437

High

1254383

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

1272805

UN13C
Protein unc-13 homolog C

1

13

High-throughput

0.437

High

1272821

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.437

High

269256

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

622199

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

949915

KR103
Keratin-associated protein 10-3

1

0

High-throughput

0.251

Low

1272810

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025