Protein: H2AV
Histone H2A.V (H2A.F/Z) (H2A.Z variant histone 2)

Gene: H2AV, H2AZ2
Organism: Homo sapiens
Interactions: 147
UniProt ID: Q71UI9

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0006325 - chromatin organization
GO:0030527 - structural constituent of chromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1259621

H2B1H
Histone H2B type 1-H

3

20

High-throughput

0.839

High

242088

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.754

High

372386

MYC
Myc proto-oncogene protein

2

10

High-throughput

0.754

High

502028

H2AZ
Histone H2A.Z

2

20

High-throughput

0.754

High

979876

H4
Histone H4

2

17

High-throughput

0.754

High

1259617

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

6

High-throughput

0.691

High

943378

H2BFS
Histone H2B type F-S

1

20

High-throughput

0.665

High

1208843

H2B2F
Histone H2B type 2-F

1

20

High-throughput

0.665

High

1259619

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

2

Small-scale

0.647

High

129203

MEN1
Menin

1

1

High-throughput

0.618

High

179223

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

9

Small-scale

0.618

High

256904

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.618

High

406312

MYCN
N-myc proto-oncogene protein

1

11

High-throughput

0.618

High

449741

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.618

High

521770

H14
Histone H1.4

1

20

High-throughput

0.618

High

648368

USF1
Upstream stimulatory factor 1

1

13

High-throughput

0.618

High

659908

H2B1O
Histone H2B type 1-O

1

20

High-throughput

0.618

High

888148

MCM2
DNA replication licensing factor MCM2

1

20

High-throughput

0.618

High

946814

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.618

High

980869

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

987087

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

High-throughput

0.618

High

987391

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

18

High-throughput

0.618

High

998473

H31
Histone H3.1

1

20

High-throughput

0.618

High

1016975

H33
Histone H3.3

1

20

High-throughput

0.618

High

1029323

SET
Protein SET

1

20

High-throughput

0.618

High

1033037

EWS
RNA-binding protein EWS

1

3

High-throughput

0.618

High

1155487

EZH2
Histone-lysine N-methyltransferase EZH2

1

19

High-throughput

0.618

High

1161913

H31T
Histone H3.1t

1

20

High-throughput

0.618

High

1239447

H3C
Histone H3.3C

1

20

High-throughput

0.618

High

1259622

H2B1A
Histone H2B type 1-A

1

20

High-throughput

0.618

High

1259632

H2B1L
Histone H2B type 1-L

1

20

High-throughput

0.618

High

1259637

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

7

High-throughput

0.618

High

1259642

RAD18
E3 ubiquitin-protein ligase RAD18

1

6

High-throughput

0.618

High

1259646

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.618

High

1259647

UBQL2
Ubiquilin-2

1

20

High-throughput

0.618

High

260109

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

1259616

SLN11
Schlafen family member 11

2

7

Small-scale

0.584

High

1014138

CBX1
Chromobox protein homolog 1

1

20

Small-scale

0.575

High

396388

ESR1
Estrogen receptor

2

14

High-throughput

0.571

High

436692

KPCB
Protein kinase C beta type

2

12

High-throughput

0.571

High

631304

RAB5A
Ras-related protein Rab-5A

2

3

High-throughput

0.571

High

1259639

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

2

14

High-throughput

0.571

High

389427

FINC
Fibronectin

1

6

High-throughput

0.536

High

447145

NPM
Nucleophosmin

1

8

High-throughput

0.536

High

484577

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

640931

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

2

High-throughput

0.536

High

788076

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.536

High

1113497

CUL3
Cullin-3

1

17

High-throughput

0.536

High

1114910

CUL4A
Cullin-4A

1

17

High-throughput

0.536

High

1115268

CUL4B
Cullin-4B

1

17

High-throughput

0.536

High

1259631

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

20

High-throughput

0.536

High

1259648

RUVB2
RuvB-like 2

1

13

High-throughput

0.536

High

891216

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.508

High

422409

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

909059

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.489

High

1259613

COX15
Heme A synthase COX15

1

1

High-throughput

0.489

High

1259627

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

1

High-throughput

0.489

High

1259650

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

125512

LEG9
Galectin-9

1

1

High-throughput

0.479

High

132118

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

8

High-throughput

0.479

High

170208

AURKA
Aurora kinase A

1

13

High-throughput

0.479

High

187117

PPM1G
Protein phosphatase 1G

1

13

High-throughput

0.479

High

298401

DNJC8
DnaJ homolog subfamily C member 8

1

3

High-throughput

0.479

High

315717

RECQ4
ATP-dependent DNA helicase Q4

1

11

High-throughput

0.479

High

324944

HEXI1
Protein HEXIM1

1

14

High-throughput

0.479

High

325905

UBR5
E3 ubiquitin-protein ligase UBR5

1

11

Small-scale

0.479

High

426522

HMGN2
Non-histone chromosomal protein HMG-17

1

12

High-throughput

0.479

High

445934

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

520599

RARA
Retinoic acid receptor alpha

1

12

Small-scale

0.479

High

547462

DMD
Dystrophin

1

3

High-throughput

0.479

High

558224

XRCC6
X-ray repair cross-complementing protein 6

1

8

High-throughput

0.479

High

567433

TCTP
Translationally-controlled tumor protein

1

4

High-throughput

0.479

High

581131

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.479

High

583319

FOLR1
Folate receptor alpha

1

1

High-throughput

0.479

High

588992

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

606869

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

613087

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

615562

NELFE
Negative elongation factor E

1

2

High-throughput

0.479

High

629928

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

651677

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

4

Small-scale

0.479

High

655850

TBG1
Tubulin gamma-1 chain

1

3

High-throughput

0.479

High

695780

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

718828

CCND2
G1/S-specific cyclin-D2

1

1

Small-scale

0.479

High

755968

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.479

High

830956

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

851778

NKX21
Homeobox protein Nkx-2.1

1

2

High-throughput

0.479

High

934777

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

982472

RS15
Small ribosomal subunit protein uS19

1

5

High-throughput

0.479

High

983859

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

High-throughput

0.479

High

988473

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

High-throughput

0.479

High

1008780

RED1
Double-stranded RNA-specific editase 1

1

6

High-throughput

0.479

High

1013797

RL24
Large ribosomal subunit protein eL24

1

1

High-throughput

0.479

High

1015545

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.479

High

1096729

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.479

High

1100853

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

1103827

TARB1
tRNA

1

1

High-throughput

0.479

High

1136803

MO4L2
Mortality factor 4-like protein 2

1

6

Small-scale

0.479

High

1138337

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1141188

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1194169

LARP7
La-related protein 7

1

20

High-throughput

0.479

High

1214851

ARM12
Armadillo repeat-containing protein 12

1

1

Small-scale

0.479

High

1259614

MEPCE
7SK snRNA methylphosphate capping enzyme

1

14

High-throughput

0.479

High

1259615

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

8

High-throughput

0.479

High

1259618

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

1259624

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1259626

OPTN
Optineurin

1

20

High-throughput

0.479

High

1259628

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

8

Small-scale

0.479

High

1259629

CI072
Guanine nucleotide exchange factor C9orf72

1

12

High-throughput

0.479

High

1259633

VRK1
Serine/threonine-protein kinase VRK1

1

4

High-throughput

0.479

High

1259634

OVOL2
Transcription factor Ovo-like 2

1

6

Small-scale

0.479

High

1259636

FACD2
Fanconi anemia group D2 protein

1

10

High-throughput

0.479

High

1259638

RNF38
E3 ubiquitin-protein ligase RNF38

1

6

Small-scale

0.479

High

1259643

MRGBP
MRG/MORF4L-binding protein

1

1

Small-scale

0.479

High

1259645

MO4L1
Mortality factor 4-like protein 1

1

6

Small-scale

0.479

High

1154620

GRK1
Rhodopsin kinase GRK1

1

9

High-throughput

0.470

High

214496

HXA2
Homeobox protein Hox-A2

1

0

High-throughput

0.458

High

1259644

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

430068

JUN
Transcription factor Jun

1

12

High-throughput

0.445

High

530000

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.445

High

1103249

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.445

High

1259641

LN28A
Protein lin-28 homolog A

1

20

High-throughput

0.445

High

170835

CLGN
Calmegin

1

2

High-throughput

0.437

High

192498

INSI1
Insulin-induced gene 1 protein

1

1

High-throughput

0.437

High

272278

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.437

High

293910

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

318812

RHBT1
Rho-related BTB domain-containing protein 1

1

8

High-throughput

0.437

High

353409

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.437

High

418223

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

768496

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

914644

RM12
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.437

High

947215

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

5

High-throughput

0.437

High

1126964

RBM39
RNA-binding protein 39

1

11

High-throughput

0.437

High

1134962

CUL7
Cullin-7

1

2

High-throughput

0.437

High

1137805

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

1254358

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.437

High

1259625

CHM4C
Charged multivesicular body protein 4c

1

5

High-throughput

0.437

High

1259630

PRAM
PML-RARA-regulated adapter molecule 1

1

11

High-throughput

0.437

High

1259635

RIOK1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.437

High

1259640

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1259649

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.437

High

1259651

INSI2
Insulin-induced gene 2 protein

1

1

High-throughput

0.437

High

635893

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

87494

OSCRI
SCRIB overlapping open reading frame protein

1

1

High-throughput

0.407

High

328053

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

High-throughput

0.407

High

1259620

TM9S4
Transmembrane 9 superfamily member 4

1

0

High-throughput

0.279

Low

945261

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.249

Low

1259623

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025